Comparison of fasting and non-fasting serum lipid profile in healthy population

K. S. Mandle; Viplav Prashant; Gopal K. Sahu

doi:10.18203/2320-6012.ijrms20190924

Authors

K. S. Mandle Department of Biochemistry, Pt. J. N. M. Medical College, Raipur, Chhattisgarh, India http://orcid.org/0000-0002-0006-0404
Viplav Prashant Department of Biochemistry, Govt Dental College, Raipur, Chhattisgarh, India http://orcid.org/0000-0003-2885-0392
Gopal K. Sahu Department of Biochemistry, Pt. J. N. M. Medical College, Raipur, Chhattisgarh, India http://orcid.org/0000-0003-3466-1897

DOI:

https://doi.org/10.18203/2320-6012.ijrms20190924

Keywords:

Cholesterol, Fasting, Lipid profile, Non-fasting, Triglyceride

Abstract

Background: Serum lipids are routinely used for the assessment of cardiovascular risk. The test is usually performed under fasting condition. However, recently non-fasting lipid profile is also measured in certain cases. The present study was intended to estimate the concentration of total cholesterol (TC), triglyceride (TG), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C) and VLDL cholesterol (VLDL-C) in fasting as well as non-fasting blood samples of a group of normal male and female subjects.

Methods: The study recruited 50 normal healthy male and female subjects within the age group of 12-48 years. The concentration of TC, TG, HDL-C, LDL-C and VLDL-C in serum of these subjects were quantitatively determined using the commercially available kits based on CHOD/POD method.

Results: The mean concentration of non-fasting TC, TG, HDL-C, LDL-C and VLDL-C was found to be 141.20 mg/dl, 132.20 mg/dl, 50.39 mg/dl, 64.30 mg/dl, 26.44 mg/dl respectively. On the other hand, the mean concentration of fasting TC, TG, HDL-C, LDL-C and VLDL-C was found to be 112.37 mg/dl, 100.90 mg/dl, 38.59 mg/dl, 53.59 mg/dl and 20.18 mg/dl respectively. The concentration of fasting lipid profile parameters was significantly low from the respective parameters of non-fasting lipid profile.

Conclusions: The present study reveals that there was an increase in the levels of TC, TG, HDL-C, LDL-C, and VLDL-C in non-fasting state compared to the fasting state. Measuring the lipid profile parameters under non-fasting state cannot be usually considered for assessment of cardiovascular risk and for other clinical purposes.

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Author Biography

K. S. Mandle, Department of Biochemistry, Pt. J. N. M. Medical College, Raipur, Chhattisgarh, India

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