DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20190926

Differences of lipid profile, body fat percentage, and waist circumference between childbearing age women acceptors of depot medroxy progesterone acetate contraceptive injection with non-acceptors in Padang City 2017

Utami Ariyasra, Mohamad Reza, Dessy Arisanty, Nur Indrawaty Lipoeto

Abstract


Background: A hormonal contraception which considered ideal is depot medroxy progesteron acetat. There are large number of acceptors choose this contraception because this contraception is considered safe, effective, and can be used after labor. The possible side effect which can occur are increase of lipid profile, body fat percentage, and waist circumference. The purpose of this study is to see the differences between lipid profile, body fat percentage, and the waist circumference of women of childbearing age who use depot medroxy progesteron acetat injection compared with non-acceptors.

Methods: This study was observational study with a cross sectional comparative approach and was conducted at the Regional Technical Services Unit (UPTD) at Regional Health Laboratory in West Sumatera Province from December 2017 until June 2018. The samples were 46 DMPA acceptors and 46 non-acceptors. The sampling method used random sampling technique. The measurements of lipid profile was conducted with colorimetric enzymatic method, which is GPO-PAP for triglycerides, and CHOD-PAP for total cholesterol, HDL and LDL. The percentage of body fat examination was conducted using Bioelectrical Impedance Analysis (BIA). The obtained data were analyzed by using t-test. Abnormal data were confirmed by Mann-whitney non-parametric test with p<0.05.

Results: The results showed a significant difference between DMPA acceptors and non-acceptors (p<0.05). In total cholesterol (p = 0.000), LDL (p = 0.000), triglycerides (p = 0.000), body fat percentage (p = 0.007), body mass index (p = 0.004), and waist circumference (p = 0.001). But, in HDL there was no significant difference between DMPA acceptors and non-acceptors with p value = 0.302 (p>0.05). There were significant differences in total cholesterol, LDL, triglycerides, fat percentage, body mass index, and the circumference of waist in both DMPA acceptors and non acceptors. There were no significant difference in HDL levels between DMPA acceptors and non acceptors.

Conclusions: There were significant differences in total cholesterol, LDL, triglycerides, fat percentage, body mass index, and waist circumference between DMPA acceptors and non-acceptors. There was no significant difference in HDL between DMPA acceptors and non-acceptors.

Keywords


Body fat percentage, DMPA, Lipid profile, Waist circumference

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References


BPS. The Population Growth Rate in Indonesia, 2010. Available at http://www.bps.go.id/. Accessed 26 January 2017.

BKKBN. Family Planning Statistics Data of West Sumatra Province 2016, Biro Pusat Statistik Sumatera Barat, 2016. Available at www.bps-sumbar.go.id. Accessed 5 February 2018.

Baziad A. A hormonal contraception. Jakarta: PT Bina Pustaka Sarwono Prawirohardjo. 2008:158-160.

Jhon A. Dislipidemia. The Medicine Text Book Part III Edition IV, Published by Medical Faculty, Indonesian University; 2007:123-125.

Runnebaum, Rabe, T eds. Fertility Control-Up date and Trends. Springer-Verlag; 2009:121-49.

Sastroasmoro S, Ismael S. The Basic of Clinical Research Methods 2th edition. Jakarta: Sagung Seto; 2011:39-45.

Guyton AC, Hall. The Medical Text Book of Human Physiology Part 11. The Medicine Text Book of EGC, Jakarta; 2008:200-203.

Youzbaki WB. C-reactive protein and lipid profile among depo medroxy progesterone acetate injections users. Ann College Med. 2011;37(1&2):48-56.

Batista GA, Souza AL, Marin DM, Sider M, Melhado VC, Fernandes AM, et al. Body composition, resting energy expenditure and inflammatory markers: impact in users of depot medroxyprogesterone acetate after 12 months follow-up. Archives of endocrinology and metabolism. 2017 Feb;61(1):70-5.

Bonny AE, Secic M, Cromer BA. A longitudinal comparison of body composition changes in adolescent girls receiving hormonal contraception. J Adolescent Heal. 2009 Oct 1;45(4):423-5.

Safitri, Elisa M. The use of hormonal contraception on maternal physical changes. Medan: Helvetia. 2015;35-2.

Bonny AE, Ziegler J, Harvey R, Debanne SM, Secic M, Cromer BA. Weight gain in obese and nonobese adolescent girls initiating depot medroxyprogesterone, oral contraceptive pills, or no hormonal contraceptive method. Archives of Pediatrics Adolescent Med. 2006 Jan 1;160(1):40-5.

Yadav BK, Gupta RK, Gyawali P, Shrestha R, Poudel B, Sigdel M, et al. Effects of long-term use of depo-medroxyprogesterone acetate on lipid metabolism in Nepalese women. Korean J Lab Med. 2011 Apr 1;31(2):95-7.

Dasuki, D. Effect of hormonal contraception planibu and DMPA on liver function and lipid profile. J Contraception. 2008;24(3):56-61.

Speroff L, Glass RH, Kase NG. Long Acting Methods of Contraception on Clinical Gynecologic Endocrinolgy and Infertility. 6th ed. Lippincott Williams and Wilkins; 2009:962-966.

Raalte V, Ouwens D, dan Diamant M. Novel insight into glucocorticoid-mediated diabetogenic effects: toward expansion of therapeutic option. Eur J Clin Invest. 2009;39:81-9.

Lipoeto NI. Local food supplementation and psychosocial stimulation improve linear growth and cognitive development among Indonesian infants aged 6 to 9 months. Asia Pacific J Clin Nutri. 2017;26(1):97-103.