DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20190950

Ultrasound guided fine needle aspiration cytology of gall bladder mass and mural thickening: a radio-pathological correlation

Geetanjali Barman, Kabita Bujarbaruah, Binoy Kumar Choudhury, Shiraj Ahmed, Jagannath Dev Sharma, Amal Chandra Kataki

Abstract


Background: Carcinoma of the gall bladder (GB) is the commonest malignancy of the biliary tract. Ultrasound (US) guided Fine Needle Aspiration Cytology (FNAC) plays a major role in early detection of malignancy in a suspicious GB lesion. The aim of this study was to evaluate the safety and diagnostic accuracy of US guided FNAC in detection of GB malignancy, to find the association of gall stones with GB malignancy, to study the ultrasound pattern of GB malignant mass and demographic profile of the disease in North eastern India.

Methods: The study was conducted retrospectively in Dr. B. Borooah Cancer Institute, Guwahati from January 2016 to December 2017. A total number of 173 patients suspected to have GB malignancy were subjected to US guided FNAC.

Results: Total 161 patients were positive for malignancy with significant female majority. There were 124 female (77.02%) and 37 males (22.98%) in the range of 29 to 82 years. Male female ratio was 1:3.5. One was diagnosed as xanthogranulomatous cholecystitis and another was chronic cholecystitis. FNAC remained inconclusive in 2 patients. There was no major procedure related complication. Adenocarcinoma was the most common malignancy found in 146 patients (98.68%). Cholelithiasis was associated in 88.19% of malignant lesions.

Conclusions: US-guided FNAC is a safe, highly accurate and reliable procedure for early detection of GB malignancy.

Keywords


Cytology, Gallbladder, Malignancy, Mural thickening, North East India, Ultrasound

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References


Bhartiya R, Mallick S, Mallik M, Agrawal P, Singh R, Singh RV. Ultrasound-guided fine needle aspiration cytology diagnosis of gall bladder lesions with application of WHO histological classification of tumors on cytoaspirate material. Ann Trop Med Pub Heal. 2017;10:138-42.

Kumar N, Singhal P, Agarwal A, Khan MA. Cytopathological diagnosis of gallbladder mass and mural thickening based on imaging findings: A prospective study of 51 cases. J Cytol. 2015;32:234-7.

Venkataramu NK, Sood BP, Gupta S, Gulati M, Khandelwal N, Suri S. Ultrasound-guided fine needle aspiration biopsy of gall bladder malignancy. Acta Radiol. 1999;40:4:436-9.

Singh P, Jaiswal VK, Singh G. Diagnostic accuracy of usg-guided FNAC in gall bladder mass. Rec Adv Path Lab Med. 2017;3:1-3.

Das DK, Tripathi RP, Bhambhani S, Chachra KL, Sodhani P, Malhotra V. Ultrasound guided fine needle aspiration cytology diagnosis of gall bladder lesions: a study of 82 cases. Diag Cytopathol. 1998;18:258-64.

Yadav R, Jain D, Mathur SR, Sharma A, Iyer VK. Gall bladder Carcinoma: An attempt of WHO histological classification of fine needle aspiration material. Cytol J. 2013;10:12.

Rammohan A, Cherukuri SD, Sathyanesan J, Palaniappan R, Govindan M. Xanthogranulomatous cholecystitis masquerading as gallbladder cancer: can it be diagnosed preoperatively? Gasteroenterol Res Pract. 2014:253645

Shukla S, Krishnani N, Jain M, Pandey R, Gupta RK. Xanthogranulomatous Cholecystitis. Fine needle aspiration cytology in 17 cases. Acta Cytol. 1997;41:413-8.

Barbhuiya M, Bhunia S, Kakkar M, Shrivastava B, Tiwari PK, Gupta S. Fine needle aspiration cytology of lesions of liver and gall bladder: An analysis of 400 consecutive aspirations. J Cytol. 2014;31:20-4.

Shukla VK, Pandey M, Kumar M, Sood BP, Gupta A, Aryya NC, et al. Ultrasound-guided fine needle aspiration cytology of malignant gallbladder masses. Acta Cytol. 1997;41:1654-8.

Kumar R, Srinivasan R, Gupta N, Dey P, Rajwanshi A, Nijhawan R, et al. Spectrum of gallbladder malignancies on fine-needle aspiration cytology: 5 years retrospective single institutional study with emphasis on uncommon variants Diag Cytopathol. 2017;45:36-42.

Gupta P, Agarwal A, Gupta V, Singh PK, Pantola C, Amit S. Expression and clinicopathological significance of estrogen and progesterone receptors in gallbladder cancer. Gastrointest Cancer Res. 2012;5:41-7.

Iqbal M, Gondal KM, Qureshi AU, Tayyab M. Comparative study of ultrasound guided fine needle aspiration cytology with open/laparoscopic biopsy for diagnosis of carcinoma gallbladder. J Coll Physicians Surg Pak. 2009;19:17-20.

Tandan P, Gautam W. Fine needle aspiration cytology in lesions of gall bladder-experience in a primary care setting. Int J Trop Disease Heal. 2017;21:1-7.

Handa U, Nanda A, Mohan H, Kochhar S, Sachdev A. Cytological diagnosis of gallbladder lesions-A study of 150 cases. Ind J Surg. 2010;72:181-4.