Study of asymptomatic bacteriuria in pregnant women: prevalence, isolates and their antibiotic sensitivity pattern

K. Sri Sandhya; Ch. Pranuthi Mispah; Santosha Kelamane

doi:10.18203/2320-6012.ijrms20191295

Authors

K. Sri Sandhya Department of Microbiology, Prathima Institute of Medical Sciences, Nagunur, Karimanagar, Telangana, India
Ch. Pranuthi Mispah Consultant Microbiologist, Pace Hospitals, Hyderabad, Telangana, India
Santosha Kelamane Department of Microbiology, Prathima Institute of Medical Sciences, Nagunur, Karimanagar, Telangana, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20191295

Keywords:

Asymptomatic bacteriuria, Escherichia coli, Pregnancy

Abstract

Background: Asymptomatic bacteriuria (ASB) is common in pregnant women due to morphological and physiological changes in the genitor-urinary tract, which untreated may lead to complications like pyelonephritis and may also effect the fetus. The objective of our study was to determine the prevalence of ASB in pregnant women, to identify the organisms responsible and their antibiotic sensitivity pattern.

Methods: A clean catch midstream urine was collected from 250 pregnant women in different trimesters attending antenatal OPD in a tertiary care hospital. Isolates and their antibiogram were obtained by conventional methods.

Results: Among 250 pregnant women, 23(9.2%) had shown significant bacteriuria, and majority (52.1%) were in 3^rd trimester. Escherichia coli (56.5%) was the commonest isolate followed by Klebsiella pneumoniae (17.4%). Most of the isolates showed sensitivity to imipenam, nitrofurantoin and cefepime.

Conclusions: Asymptomatic bacteriuria is common during pregnancy which requires a routine examination of urine for culture and sensitivity and the positive cases should be treated with appropriate antibiotics to prevent any further complication.

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References

Mendell GL, Bennet JE, Dolin R. urinary tract infections. Mendell, Douglas and Bennett’s principles and practice of infectious diseases. 7th ed. 2009:842-854.

Cunningham FG, Gant NF, Laveno KJ. Renal and urinary tract disorders. William Obstetrics. 24th ed. New York: McGraw-Hill Medical Publishing Division; 2014:1052-1056.

Anantnarayanan R, Kapil A. Paniker’s Textbook of Microbiology. 9th ed. 2013:277-280.

Jayalakshmi J, Jayaram VS. Evaluation of various screening tests to detect asymptomatic bacteriuria in pregnant women. Indian J Pathol Microbiol. 2008;51(3):379-81.

Celen S, Oruc AS, Karayalcin R, Saygan S, Unlu S, Polat B, et al. Asymptomatic bacteriuria and microbial susceptibility Patterns in Obstetric population. ISRN Obstet Gynaecol. 2011; 2011:

Kacmaz B, Cakir O, Aksoy A, Biri A. Evaluation of rapid urine screening tests to detect asymptomatic bacteriuria in pregnancy. Jpn J Infec Dis. 2006;59(4):261-3.

Imade PE, Izekor PE, Eghafona NO, Enabulele OI, Ophori E. Asymptomatic bacteriuria among pregnant women. N Am J Med Sci. 2010;2(6):263-6.

Colgan R, Nicolle LE, Mcglone A, Thomas M.Hooton. Asymptomatic bacteriuria in adults. Am Family Physician. 2006;74(6):985-90.

Chandel LR, Kanga A, Thakkur K, Mokta KK, Sood A, Chauhan S. Prevalence of pregnancy associated Asymptomatic bacteriuria: a study done in a tertiary care hospital. J Obstet Gynaecol India. 2012;62(5):511-4.

Lavanya SV, Jogalakshmi D. Asymptomatic bacteriuria in antenatal women. Indian J Med Microbiol. 2002;20(2):105-6.

Jain V, Das V, Agarwal A, Pandey A. Asymptomatic bacteriuria and obstetric outcome following treatment in early versus late pregnancy in North Indian Women. Indian J Med Res. 2013;137(4):753-8.

Demilie T, Beyene G, Melaku S, Tsegaye W. Urinary bacterial profile and antibiotic susceptibility pattern among pregnant women in north west Ethiopia. Ethiop J Health Sci. 2012;22(2):121-8.

Gayathree L, Shetty S, Deshpande SR, Venkatesh DT. Screening for asymptomatic bacteriuria in pregnancy: An evaluation of various screening tests in Hassan District Hospital, India. J Clin Diagn Res. 2010;4(4):2702-6.

Rohini UV, Reddy GS, Kandati J, Ponugoti M. Prevalence and associated risk factors of asymptomatic bacteriuria in pregnancy with bacterial pathogens and their antimicrobial susceptibility in a tertiary care hospital. Int J Reprod Contracept Obstet Gynecol. 2017;6:558-62.

Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. Twenty-Fifth Informational Supplement. M100-S25. 2015;35(3).

Sujatha R, Nawani M. Asymptomatic bacteriuria among pregnant women attending the antenatal clinic in a tertiary care center at Kanpur. J Clin Diag Res. 2014;8(4):DC01-D03.

Mukherjee K, Golia S, Vasudha CL, Babita, Bhattacharjee D, Chakrobaorti G. A study on asymptomatic bacteriuria in pregnancy: Prevalence, etiology and comparison of screening methods. Int J Res Med Sci. 2014;2:1085-91.

Khan S, Singh P, Siddiqui Z, Ansari M. Pregnancy-associated asymptomatic bacteriuria and drug resistance. J Taibah University Med Sci. 2015 Sep 1;10(3):340-5.

Patnaik M, Panigrahi K, Das B, Pathi B, Poddar N, Lenka PR, et al. Prevalence, risk factors and causative organisms of asymptomatic bacteriuria in pregnancy. Int J Adv Med. 2017;4:1348-54.

Bose AM, Sreekumary PK, Pulikkottil SK. Microbiological profile of asymptomatic bacteriuria in pregnancy. Int J Reprod Contracept Obstet Gynecol. 2017;6:1352-61.

Prasanna B, Naimisha M, Swathi K, Shaik MV. Prevalence of Asymptomatic Bacteriuria in Pregnant women, Isolates, and their Culture Sensitivity Pattern. Int J Curr Microbiol App Sci. 2015;4(8):28-35.

Senthinath TJ, Rajalakshmi PC, Keerthana R, Vigneswari RS, Revathi P, Prabhu N, et al. prevalence of asymptomatic bacteriuria among antenatal women in rural tertiary care hospital, Tamilnadu, India. Int J Curr Microbiol App Sci. 2013;2(1):80-5.

Ramalingam K, Surasani VM, Bollu M. Prevalence of Asymptomatic bacteriuria in Antenatal Women Coming to NRIMC and GH, Bangladesh J Obstet Gynaecol. 2015;30(1):30-6.

Alfred AO, Chiedozie I and Martin DU. Pattern of asymptomatic bacteriuria among pregnant women attending antenatal clinic at a private health facility in Benin, South-South Nigeria. Ann Afr Med. 2013;12(3):160-4.

Enayat K, Fariba F, Bahram N. Asymptomatic bacteriuria among pregnant women referred to outpatient clinics in Sanandaj, Iran. Int Braz J Urol. 2008;34(6):699-707.