HLA-B*44 allele associated with clinical parameters in HIV-1 infected Moroccan cohort

Fatima Youssoufi; Hicham El Annaz; Abdelilah Laraqui; Reda Tagajdid; Rachid Abi; Safae Elkochri; Rachid Frikh; Tahar Bajjou; Naoufal Hjira; Yassine Sekhsokh; Saad Mrani

doi:10.18203/2320-6012.ijrms20191352

Authors

Fatima Youssoufi Research Team in Molecular Virology and Oncobiology, Faculty of Medicine and Pharmacy, Mohammed V. University, Rabat, Morocco
Hicham El Annaz Research Team in Molecular Virology and Oncobiology, Faculty of Medicine and Pharmacy, Mohammed V. University, Rabat, Morocco
Abdelilah Laraqui Biosafety Level 3 and Research Laboratory, Mohammed V. Military Teaching Hospital of Rabat, Morocco
Reda Tagajdid Faculty of Medicine and Pharmacy of Fes, Sidi Mohammed Ben Abdellah University, Fes, Morocco
Rachid Abi Research Team in Molecular Virology and Oncobiology, Faculty of Medicine and Pharmacy, Mohammed V. University, Rabat, Morocco
Safae Elkochri Research Team in Molecular Virology and Oncobiology, Faculty of Medicine and Pharmacy, Mohammed V. University, Rabat, Morocco
Rachid Frikh Department of Dermatology, Mohammed V. Military Teaching Hospital of Rabat, UPR of Dermatology, Faculty of Medicine and Pharmacy, Mohammed V. University, Rabat, Morocco
Tahar Bajjou Biosafety Level 3 and Research Laboratory, Mohammed V. Military Teaching Hospital of Rabat, Morocco
Naoufal Hjira Department of Dermatology, Mohammed V. Military Teaching Hospital of Rabat, UPR of Dermatology, Faculty of Medicine and Pharmacy, Mohammed V. University, Rabat, Morocco
Yassine Sekhsokh Biosafety Level 3 and Research Laboratory, Mohammed V. Military Teaching Hospital of Rabat, Morocco
Saad Mrani Research Team in Molecular Virology and Oncobiology, Faculty of Medicine and Pharmacy, Mohammed V. University, Rabat, Morocco

DOI:

https://doi.org/10.18203/2320-6012.ijrms20191352

Keywords:

HLA-B*44 allele, HIV infection, Morocco

Abstract

Background: The human leukocyte antigen-B*44 (HLA-B*44) allele has been reported to have promising results in the control of human immunodeficiency virus-1 (HIV-1) infection and associated with protection against HIV-1 disease progression. In the Moroccan HIV-1 infected patients, the contribution of this allele has not been established. This study aimed to evaluate the distribution of HLA-B*44 allele among HIV-1-infected in Morocco. Additionally, investigate HLA-B*44 allele association with demographical and HIV clinical parameters.

Methods: One hundred and sixty-seven HIV-1 infected, antiretroviral naive individuals were enrolled in this study. The HLA-B*44 allele screening was performed using the PCR amplification.

Results: Of the 167 individuals genotyped, 26 (16%) of them expressing the HLA-B*44 allele. Clinical stages at diagnosis, median pre-treatment HIV viral load (pVL) and CD4 T cell counts differ significantly (p = 0.0001, p=0.001 and p=0.0001 respectively) between the patients who had been expressing the HLA-B*44 allele and patients who had not been expressing this allele. The presence of HLA-B*44 allele was significantly associated with pVL and CD4 T cell counts (p=0.004 and p=0.0001 respectively). The bivariate analysis has showed that the expression of the HLA-B*44 allele was strongly associated with advanced HIV infection (Odd ratio (OR) 0.12 (95% confidence interval (CI) 0.04-0.37), p=0.0001).

Conclusions: Author have described for the first time in Morocco the association of the HLA-B*44 allele with the clinical parameters of HIV infection. These results expand the knowledge of the distribution and effect of this allele in the Moroccan population.

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