Clinical and hematological profile of pancytopenia in a tertiary care hospital of Southern Odisha, India


  • Namita Mohanty Department of General Medicine, MKCG Medical College, Berhampur, Odisha, India
  • Arjun Nataraj Kannan Department of General Medicine, MKCG Medical College, Berhampur, Odisha, India
  • Nikhil Jain Department of Pathology, MKCG Medical College, Berhampur, Odisha, India



Aplastic anemia, Dengue, Malaria, Megaloblastic anemia, Pancytopenia, Sepsis


Background: Pancytopenia (anemia, thrombocytopenia and leukopenia) is a common haematological condition with various etiologies like ineffective haematopoiesis, bone marrow suppression, bone marrow infiltration and peripheral destruction of blood cells. The present study was done to see the clinical features and etiologies of pancytopenia in this geographical region.

Methods: About 150 patients above 15 years of age after fulfilling the inclusion criteria were included in the study. They were evaluated with appropriate laboratory tests including bone marrow study, if indicated to find out the underlying etiology.

Results: Common symptoms were generalized weakness (93.3%), fever (75.3%) and dyspnoea (54%). Common physical findings were pallor (100%), lymphadenopathy (43.6%) and hepatosplenomegaly (32%). Most common causes were aplastic anemia (28%), megaloblastic anemia (20%) followed by infections like malaria (13.3%), dengue (5.3%) and sepsis (1.3%). Bone marrow was hypocellular in 50 patients (41.7%), hypercellular in 45 patients (37.5%) and normocellular in 25 patients (20.8%).

Conclusions: There are some reversible causes of pancytopenia like megaloblastic anemia, malaria, dengue and sepsis. Conditions like disseminated TB, collagen vascular diseases also can be treated with specific treatment if diagnosed early to avoid further complications.


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How to Cite

Mohanty, N., Kannan, A. N., & Jain, N. (2019). Clinical and hematological profile of pancytopenia in a tertiary care hospital of Southern Odisha, India. International Journal of Research in Medical Sciences, 7(4), 1247–1251.



Original Research Articles