DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20191339

Comparison of cardiac autonomic response in different ABO blood groups of young adults

Nadeema Rafiq, Tauseef Nabi, Quratul Ain Arifa

Abstract


Background: ABO blood group has been associated with various disease phenotypes, particularly cardiovascular disease. Abnormal autonomic response also plays a role in cardiac morbidity. Increasing attention is being focused on the role of autonomic nervous system in health and disease. The literature lacks data on the association of blood groups and cardiac autonomic function. The aim of the study was to find out the association between different blood groups and cardiovascular autonomic functions in young adults.

Methods: 150 healthy young students of MMU aged 18-25 years, divided into four groups based on ABO blood grouping, determined by agglutination test (group A, group B, group O and group AB). Various autonomic function tests done were lying to standing test, Valsalva maneuver, Hand grip test (HGT) and Cold pressor test (CPT).

Results: The mean baseline heart rate was significantly higher in group O as compared to group A. No parasympathetic alteration between different ABO blood groups was seen. Blood pressure response to HGT and CPT was not statistically significant between different blood groups.

Conclusions: Present study revealed no alteration in cardiac autonomic function with regards to ABO blood grouping in young adults.


Keywords


ABO blood groups, Cold pressor test, Hand grip test, Lying to standing test, Valsalva maneuver

Full Text:

PDF

References


Mohandas N, Narla A. Blood group antigens in health and disease. Current Opinion Hematol. 2005;12(2):135-40.

Cartron JP, Colin Y. Structural and functional diversity of blood group antigens. Transfusion Clin Biolog. 2001;8(3):163-99.

Sandler SG, Mallory D. Biological functions of blood groups in health and disease. Haematol. 1995;27(1):1-3.

Amjadi O, Rafiei A, Ajami A, Valadan R, Janbaabaei G. Blood groups: In Health and Diseases. Res Mol Med. 2015;3(4):1-9.

Garratty G. Blood groups and disease: a historical perspective. Trans Med Rev. 2000;14(4):291-301.

He M, Wolpin B, Rexrode K, Manson JE, Rimm E, Hu FB, et al. ABO blood group and risk of coronary heart disease in two prospective cohort studies. Arteriosclerosis Thrombosis Vascular Biol. 2012;32(9):2314-20.

Pramanik T, Regmi P, Shrestha P. Detection of individuals prone to develop hypertension in their future life. Nepal Med Coll J. 2008;10(1):35-7.

Schneider GM, Jacobs DW, Gevirtz RN, O'Connor DT. Cardiovascular haemodynamic response to repeated mental stress in normotensive subjects at genetic risk of hypertension: evidence of enhanced reactivity, blunted adaptation, and delayed recovery. J Human Hypertension. 2003;17(12):829.

Singh JP, Larson MG, Manolio TA, O’Donnell CJ, Lauer M, Evans JC, et al. Blood pressure response during treadmill testing as a risk factor for new-onset hypertension: the framingham heart study. Circulation. 1999;99(14):1831-6.

Champlain J, Ameringen MR. Regulation of blood pressure by sympathetic nerve fibers and adrenal medulla in normotensive and hypertensive rats. Circulation Res. 1972;31(4):617-28.

Mancia, Marco Di Rienzo, Cristina Giannattasio, Gianfranco Parati, Guido Grassi G. Early and late sympathetic activation in hypertension. Scandinavian Cardiovascul J. 1998;32(47):9-14.

DeQuattro V, Feng M. The sympathetic nervous system: the muse of primary hypertension. J Human Hypertension. 2002;16(S1):S64.

Rafiq N, Trigotra S, Nabi T. Sympathetic Overactivity in Offsprings with Hypertensive Parents. IJSR. 2018; 7(2): 18-22.

Rafiq N, Nabi T, Nazeer M. Cardiac Autonomic Dysfunction Contributes to Prehypertension Status. IJAR. 2018; 8(4): 19-21.

Rafiq N, Nabi T, Aara S, Arifa Q. Influence of Gender on Cardiac Autonomic Reactivity in Young Adults. JMSCR. 2018; 6(2): 810-7.

Anthony DM, Hamid SH, Rashmi TM. Autonomic Response to Cold Pressor Test in Relation to ABO Blood Groups. International Research Journal of Biological Sciences. 2013; 2(10):30-5.

Uppangala C, Kodavanji B, Na V, Noojibail A, Kini RD, Arunkumar N, et al. Comparison of heart rate variability in different ABO blood groups of young adults. Inter J Med Sci Pub Heal. 2014;3(12):1466-70.

Khandelwal E, Jaryal AK, Deepak KK. Cardiovascular autonomic functions and cerebral autoregulation in patients with orthostatic hypotension. Ind J Med Res. 2011;134(4):463.

Deepak D, Sinha AN, Gusain VS, Goel A. A study on effects of meditation on sympathetic nervous system functional status in meditators. J Clin Diagn Res. 2012;6(6):938.

Mentis A, Blackwell CC, Weir DM, Spiliadis C, Dailianas A, Skandalis N. ABO blood group, secretor status and detection of Helicobacter pylori among patients with gastric or duodenal ulcers. Epidemiol Inf. 1991;106(2):221-9.

Abdollahi AA, Qorbani M, Salehi A, Mansourian M. ABO blood groups distribution and cardiovascular major risk factors in healthy population. Iran J Pub Heal. 2009;38(3):123-6.

Callender S, Langman MJ, Macleod IN, Mosbech J, Nielsen KR. ABO blood groups in patients with gastric carcinoma associated with pernicious anaemia. Gut. 1971;12(6):465-7.

Kumar NC, Nadimpalli M, Vardhan VR, Gopal SD. Association of ABO blood groups with Chikungunya virus. Virol J. 2010;7(1):140.

Rowe JA, Opi DH, Williams TN. Blood groups and malaria: fresh insights into pathogenesis and identification of targets for intervention. Current Opinion Hematol. 2009;16(6):480.

Greenwell P. Blood group antigens: molecules seeking a function?. Glycoconjugate J. 1997;14(2):159-73.