Therapeutic effect of al-Quran murattal on anxiety, sFlt-1, PIGF and sFlt-1/PIGF ratio in pregnant women with risk of preeclampsia


  • Mamlukah Mamlukah Department of Health Reproductive, Public Health Program of Stikes Kuningan, Indonesia
  • Soeharyo Hadisaputro Department of Epidemiology, Faculty of Medicine Diponegoro University, Semarang, Indonesia
  • Ariawan Soejoenoes Department of Obstetrics & Gynecology, Faculty of Medicine Diponegoro University and Kariadi Hospital, Semarang, Indonesia
  • Zahroh Shaluhiyah Department of Health Promotion, Faculty of Public Health Diponegoro University, Semarang, Indonesia
  • M. Amin Syukur Department of Sufism, Faculty Islamic Law and Humanities, Islamic State University of Walisongo, Semarang, Indonesia



Anxiety, PIGF, Pregnant, Murattal al-Qur'an therapy, sFlt-1


Background: Pregnancy was a critical period. This study aimed to examine the effect of murattal al-Quran therapy on the level of anxiety, sFlt-1, and PIGF level in pregnant women with preeclampsia risk.

Methods: A quasi-experimental study was conducted in February, 2018. Ten participants received routine midwifery care were combined with murattal of the Qur'an therapy, the rests as control group. Variables were measured at pre and post 12 interventions. Interviews were conducted after the intervention.

Results: There was a mean difference of anxiety of 5.250 (SD of 11.021, 95% CI: 0.092-10,408, p-0.046), sFlt-1 p=0.411, PIGF p=0.002, sFlt-1/PIGF ratio p=0.001.

Conclusions: This study found a decrease in the level of anxiety, increase score of PIGF and decrease of sFlt-1/PIGF ratio among pregnant women with the risk of preeclampsia who received routine midwifery care plus al-Quran Murattal therapy.


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How to Cite

Mamlukah, M., Hadisaputro, S., Soejoenoes, A., Shaluhiyah, Z., & Syukur, M. A. (2019). Therapeutic effect of al-Quran murattal on anxiety, sFlt-1, PIGF and sFlt-1/PIGF ratio in pregnant women with risk of preeclampsia. International Journal of Research in Medical Sciences, 7(5), 1425–1429.



Original Research Articles