Differences of blood glucose and insulin in childbearing aged women acceptors of depo medroxy progesterone acetat with non acceptors in Padang City 2017


  • Sri Rahma Sari Magister of Biomedical Sciences, Medical Faculty, Andalas University, Padang, West Sumatera, Indonesia http://orcid.org/0000-0002-7209-657X
  • Mohamad Reza Department of Biology Sciences, Medical Faculty, Andalas University, Padang, West Sumatera, Indonesia
  • Dessy Arisanty Department of Biochemistry Sciences, Medical Faculty, Andalas University, Padang, West Sumatera, Indonesia
  • Nur Indrawaty Lipoeto Department of Biomedical Sciences, Medical Faculty, Andalas University, Padang, West Sumatera, Indonesia




Blood glucose, Depot medroxyprogesterone acetate, Insulin


Background: Contraception was the way to prevent pregnancy, both temporarily and permanently. Depot Medroxyprogesterone Acetate (DMPA) is a contraceptive injection of synthetic progesterone hormone and is injected every three months, which is most commonly used currently, but that emerging consequences of long time usage of contraception, especially the hormonal one, cannot be denied. This research was aimed to see difference in blood sugar, insulin and lipid profile in childbearing aged women who used DMPA injection and Non-Acceptors.

Methods: The study was observational with the comparative cross sectional approach. Research was conducted in the Biomedical Laboratory in Andalas University and Regional Technical Service Unit (UPTD) Laboratory in West Sumatera Province. Data was taken from December 2017 until June 2018. The research sampled 48 DMPA acceptors and 48 non-Acceptors. Sampling technique used stratified random sampling. Examination of blood glucose was carried out by the enzymatic method of GOD-PAP, ELISA for insulin. Data were analyzed using independent T-test and if the data was not normal, non parametric Mann-Whitney test was used. The differences were considered statistically significant if the value of p<0.05.

Results: The mean blood glucose acceptors 91.27mg/dl, non acceptors 88.83mg/dl and mean Insulin acceptors 23.63mIU/L, non akseptor 24.63mIU/L. The results showed that there were no significant differences between DMPA acceptors and non acceptors (p>0.05) in blood glucose (0.059) and insulin (p = 0.603).

Conclusions: There were no significant differences in blood glucose and insulin levels between DMPA acceptors and non acceptors.


Hartanto H. Family planning and contraception. Jakarta: Sinar Harapan Library; 2004:20-38.

Prawiroharjo, Sarwono. Practical guidebook for contraceptive services. Jakarta YBS-SP; 2006:200-205.

BKKBN. Family planning statistics of West Sumatra Province in 2016, West Sumatra Central Statistics Bureau, 2016. Available at www.bps-sumbar.go.id. Accessed on 20 January 2018.

BPS. Central statistical agency, national population and family planning agency. Ministry of Health in 2013. Indonesian Demographic and Health Survey, 2010-2035. Available at: https://www. bappenas.go.id/files/5413/9148/4109/Proyeksi_ Penduduk_Indonesia_2010-2035.pdf. Accessed on 20 January 2018.

Saifuddin, Bari A. Practical Handbook for Contraception Services. Jakarta: Bina Pustaka Foundation; 2006:67-71.

Speroff L, Fritz MA. Clinical gynecology endocrinology and infertility. 7th ed. Hippincott Williams and Wilkins. New York; 2005:949-964.

Berenson AB, van den Berg P, Williams KJ, Rahman M. Effect of injectable and oral contraceptives on glucose and insulin levels. Obstetrics Gynecol. 2011 Jan;117(1):41.

Inncent O, Ejiroghene OD, Ejovi O, Oghenetega AJ. Injectable progesteron contraceptine could increase the risk of insulin resistance syndrome in humans. Nigeria: Departemen of Biochemistry Delta Statc University of Ilorin. 2003;26(1):216-25.

Jamil S, Fatima S, Dilshad H, Khatoon H, Jawed N. Comparitive effects of hormonal and non hormonal contraceptives on fasting blood sugar levels. Int J Pharm Sci Res. 2017 Jul 1;8(7):3118-21.

Adult Treatment Panel (ATP) III. The national cholesterol education program (NCEP), 2002. Available at: https://www.nhlbi.nih.gov/files/docs/resources/heart/atp-3-cholesterol-full-report.pdf. Accessed on 20 January 2018.

Bennal AS, Kerure SB. Glucose handling during menstrual cycle. Int J Reprod Contracept Obstet Gynecol. 2013;2:284-7.

Mayes PA, Botham, Kathleen MB. Metabolisme Asil gliserol dan Sfingo lipid, Transport of lipids, transport and excretion of cholesterol. Translation of Brahm U Pendit Language, EGC Medical Book Publisher, Jakarta; 2012:145-152.

Almatsier S. Basic Principles of Nutrition. Jakarta: Publisher PT Gramedia Main Library; 2009:23-26.

Barnes LA, Opitz JM, Gilbert -Barness E. Obesity: Genetic, molecular and environmental aspects. 2007;143A(24):3016-34.

Susiwati S. difference of fasting blood glucose level type 2 diabet melitus patients in naf plasma based on examination time in rsud dr. m. yunus bengkulu province Bengkulu Tahun 2017. J Nursing Pub Heal. 2018 May 8;6(1).

Sacher R, McPherson R. General Chemistry. Clinical Review of Laboratory Examination Results, 11th ed. EGC. 2004:55-65.

Tugasworo D. Secondary prevention of stroke in management of post stroke. in the central Java-DIY neurology regional meeting to the xix "neurology-update." Semarang: UNDIP Publishing Agency; 2002:39-44.

University of Texas Medical Branch at Galveston. Injectable and oral birth control do not adversely affect glucose and insulin levels, study shows. 2010. Available at: www. ScienceDaily.com/releases /2010/12/101220200002.htm. Accessed on 05 February 2018.

Insulin is a polypeptide hormone that regulates carbohydrate metabolism, 2016. Available at: https://www.sciencedaily.com/terms/insulin.htm. Accessed on 05 February 2018.

Guyton AC, Hall JE. Textbook on medical physiology. The medicine text book of EGC. Jakarta; 2007:200-203.

Jhon A. Dyslipidemia. Textbook of Disease Sciences in Volume III Edition IV, Internal Medicine Publishing Center, Faculty of Medicine, University of Indonesia; 2007:123-125.

Yadav, BK. Effects of long term use of medroxy progesterone acetate on lipid metabolism in nepalese woman. tribhuvan university teaching hospital institute of medicine Nepal. Korean J Lab Med. 2011 Apr 1;31(2):95-7

Oyelola OO. Fasting plasma lipids, lipoproteins, and apolipoproteins in Nigerian women using combined oral and progestin only injectable contraceptives. J Contraception. 2013;47(5):445-54.




How to Cite

Sari, S. R., Reza, M., Arisanty, D., & Lipoeto, N. I. (2019). Differences of blood glucose and insulin in childbearing aged women acceptors of depo medroxy progesterone acetat with non acceptors in Padang City 2017. International Journal of Research in Medical Sciences, 7(4), 1140–1144. https://doi.org/10.18203/2320-6012.ijrms20191314



Original Research Articles