Metanephric adenoma of kidney: a rare and distinct entity

Purwa Patil, Varsha Bhatia, Vidya Arole, Nisha Thakare


Metanephric adenoma (MA) is an unusual renal neoplasm with benign behaviour most of the times. Clinically MA mimics malignant renal neoplasms due to nonspecific signs and symptoms such as polycythaemia, haematuria and abdominal pain. MA usually presents as a mass lesion on radiographic studies and can be found incidentally. The treatment of choice is surgical excision. Though MA is usually a benign tumour, increase in the knowledge of MA pathology may lead to less invasive treatments in the future. Less than 200 cases of metanephric adenoma are reported till date in the literature.


Metanephric adenoma, Benign, Surgical excision

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Burger M, Junker K,Denzinger S, Schubert T, Stoehr R, Wieland W et al. Metanephric adenoma of kidney: a clinicopathological and molecular study of two cases. J clin pathol. 2007;60(7):832-4.

Patel RD, Frederick L, Kohler T, Schwartz B. A Case of a Metanephric Adenoma of the Kidney Surgically Treated with Robot-Assisted Laparoscopic Partial Nephrectomy. Case reports in urology. 2013:3-6.

Kuroda N, Toi M, Hiroi M, Enzan H. Review of metanephric adenoma of the kidney with focus on clinical and pathobiological aspects. Histol Histopathol. 2003;18:253-7.

Obulareddy SJ, Xin J, Truskinovsky AM, Anderson JK, Franklin MJ, Dudek AZ. Metanephric adenoma of kidney: an unusual diagnostic challenge. Rare Tumors. 2010;2(38):103-5.

Wu J, Zhu Q, Zhu W, Zhang H. Metanephric adenoma with diffuse calcinosis: A case report. Oncology letters. 2015;10:1816-8.

Pan C, Epstein JI. Detection of chromosome copy number alterations in metanephricadenomas by array comparative genomic hybridization. Modern pathology. 2010;23:1634-40.

Argani P. Metanephric Neoplasms: The Hyperdifferentiated, Benign End of WilmsTumor Spectrum? Clin Lab Med. 2005;25:379-92.

Yaqoob N,Paryani JP, Kayani N, Rafique MZ, Biyabani R. Metanephric adenoma: a rare benign tumor. J Pak Med Assoc. 2005;55(11):511-2.

Toricelli FCM, Marchini GS, Campos RSM, Gil AO. Metanephric adenoma: clinical, imaging and Histological findings. CLINICS. 2011;66(2):359-61.

Li G, Tang Y, Zhang R, Song H, Zhang S, Niu Y. Adult metanephric adenoma presumed to be all benign? A clinical perspective. BMC Cancer. 2015;15:310.

Pins MR, Jones EC, MartulV, Kamat BR, Umlas J. RenshawAA.Metanephric Adenoma- like Tumors of Kidney. Arch Pathol Lab Med. 1999;123:415-20.

Brunelli M, Elbe JN, Zhang S, Mortignoni G, Cheng L. Metanephric adenoma lacks the Gains of Chromosomes 7 and 17 and Loss of Y That Are Typical of Papillary Renal Cell Carcinoma and Papillary adenoma.Mod Pathol. 2003;16(10):1060-3.