DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20190996

Effects of preoperative gabapentin on postoperative relief of pain in patients scheduled for surgery under general anaesthesia

Ritu Masar, Kishore Kumar Arora

Abstract


Background: To evaluate the effects of preoperative Gabapentin on postoperative relief of pain in patients scheduled for surgery under general anaesthesia. Post-operative ward and OT Department of Anaesthesia, JAH, GR Medical College, Gwalior, Madhya Pradesh, India.

Methods: The sixty patients subjected to ASA grade I and II posted for elective surgeries under general anaesthesia were randomized into 2 groups. One and half hour before surgery, Gabapentin 600 mg and placebo was given blindly to selected patients for the study. The postoperative pain was assessed with visual analogue score. Pain and side effects assessment were performed.

Results: Total 60 patients of ASA grade I and II posted for elective surgeries under GA were randomized into 2 groups. One and half hour before surgery, the drug selected for the study was given blindly with a sip of water. The mean (±SD) of VAS score was 5.86±0.34 in Group B and 5.10±0.84 in Group A. VAS score was significantly lower in Group A. With oral Gabapentin time required for rescue analgesia is delayed as compared to control group. The mean (±SD) TRA-1 was 38.40±24.61 in Group B and 44.03±8.94 in Group A.

Conclusions: Preoperative oral Gabapentin significantly decreases the severity of pain postoperatively as compared to placebo in patients posted for surgery. Time for analgesic requirement is more with oral Gabapentin. The VAS score was lower in Gabapentin group.


Keywords


General anaesthesia, Gabapentin, Postoperative pain, Visual analogue score

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References


Islam S, Jain PN. Post-operative nausea and vomiting (PONV). Indian J Anaes. 2004;48(4):253-8.

Deniz MN, Sertoz N, Erhan E, Ugur G. Effects of preoperative gabapentin on postoperative pain after radical retropubic prostatectomy. J Int Med Res. 2012;40(6):2362-9.

Corke P. Postoperative pain management. Aus Prescriber. 2013;36(6):202.

Chang CY, Challa CK, Shah J, Eloy JD. Gabapentin in acute postoperative pain management. BioMed Res Int. 2014;2014:1-7.

Waikakul W, Chalachewa T, Tantisirin N, Suranutkarin PE, Saengpetch N. Combination of gabapentin and celecoxib for analgesia after major orthopedic surgery: a randomized, controlled trial. Asian Biomed. 2011;5(1):101-10.

Kong VK, Irwin MG. Gabapentin: a multimodal perioperative drug?. Brit J Anaes. 2007;99(6):775-86.

Kumar P. Sedation and pain relief. Ind J Anaes. 2003;47(5):396-401.

Pandey CK, Priye S, Singh S, Singh U, Singh RB, Singh PK. Preemptive use of gabapentin significantly decreases postoperative pain and rescue analgesic requirements in laparoscopic cholecystectomy. Can J Anes. 2004;51(4):358.

Marashi SM, Morabi AA, Ghafari MH, Azimaraghi O, Movafegh A. The effect of pre-operative oral clonidine or gabapentin on post-operative pain intensity, morphine consumption and post-operative nausea and vomiting in patients who undergone thyroidectomy: a double-blind placebo-control study. J Anes Clin Res. 2012;3(4):2-4.

Chiu TW, Leung CC, Lau EY, Burd A. Analgesic effects of preoperative gabapentin after tongue reconstruction with the anterolateral thigh flap. Hong Kong Med J. 2012;18(1):30-4.

Jadeja CA, Jadaliwala R, Kathiria M. Pre-emptive use of gabapentin for post-operative pain relief in upper abdominal surgeries. Ind J Pain. 2014;28(2):99.

Panah Khahi M, Yaghooti AA, Marashi SH, Nadjafi A. Effect of pre-emptive gabapentin on postoperative pain following lower extremity orthopaedic surgery under spinal anaesthesia. Singapore Med J. 2011;52(12):879-82.

Spence D, Goff J, Mohan E, Bowen K, Osborne L, Maye J. Perioperative administration of gabapentin for shoulder arthroscopy: a prospective, randomized, double-blind, placebo-controlled study. AANA J. 2011;79(4).