Need of the hour: pharmacovigilance study of SGLT-2 inhibitors

Authors

  • Sapna Pradhan
  • Tejus A. Department of Pharmacology, Army College of Medical Sciences, New Delhi, India
  • Mrinalini Koley Department of Pharmacology, Army College of Medical Sciences, New Delhi, India
  • A. G. Mathur Department of Pharmacology, Army College of Medical Sciences, New Delhi, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20191305

Keywords:

Diabetes mellitus, Genital infections, Pharmacovigilance, Safety profile, SGLT-2 Inhibitors, UTI

Abstract

Background: Diabetes mellitus represents a global pandemic. Various pharmacotherapy and non-pharmacotherapy measures are advocated for its control. The latest in the pharmacotherapy are Sodium Glucose Transporter -2 (SGLT-2) inhibitors, widely used. Many studies suggest adverse effects related to SGLT-2 inhibitors, evidence still not conclusive and few data from India. Hence this study was planned.

Methods: Cross-sectional study over a period of 02 months, recorded demographic details and history of various adverse drug reactions reported with the use of SGLT-2 inhibitors.

Results: Majority of the study participants were females (58%) and belonged to the age group of 40-70 yrs. Urinary tract infections (UTI) and genital infections was more seen in the users of dapagliflozin, followed by empagliflozin and canagliflozin.

Conclusions: SGLT-2 Inhibitors offer a unique therapeutic approach to the management of Diabetes Mellitus. Further evaluation of the safety profile and the risk-benefit analysis is the need of the hour.

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Published

2019-03-27

How to Cite

Pradhan, S., A., T., Koley, M., & Mathur, A. G. (2019). Need of the hour: pharmacovigilance study of SGLT-2 inhibitors. International Journal of Research in Medical Sciences, 7(4), 1093–1097. https://doi.org/10.18203/2320-6012.ijrms20191305

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Original Research Articles