Toxicological effects of prolonged exposure of soot-polluted air on some haematological and biochemical parameters of residents of Port Harcourt
Keywords:Haematological, Lipid profile, Port Harcourt, Prolong, Soot, Soot-polluted air
Background: Soot is a by-product of incomplete combustion of carbon derived from substances that contains carbon like hydrocarbons, which is associated with various human diseases. The objectives of the studies are to evaluate the toxicological effects of prolonged exposure of soot polluted air on some haematological and biochemical parameters.
Methods: One hundred apparently healthy residents of Port Harcourt residing in soot polluted environment for a minimum of 12 months and one hundred apparently healthy subjects residing in non-soot polluted environment outside Port Harcourt were recruited for this study. 5ml of venous blood was collected from each subject after 10hours of overnight fast to estimate the PCV, Hb, RBC, WBC, lymphocytes, neutrophils, bicarbonate, total cholesterol, triglyceride, low density lipoprotein and high density lipoprotein using automated autoanalyzer.
Results: There was a statistically significant decrease in the PCV, Hb, RBC and increase in WBC, Lymphocytes and neutrophils. There was also a significant increase in the bicarbonate, total cholesterol and LDL with a decrease in HDL cholesterol as compared to the control.
Conclusions: It is concluded that prolong exposure to soot polluted air is harmful and associated with deterioration of haematological parameters and also induces oxidative stress and lipid peroxidation which may increase morbidity and mortality.
Long CM, Nascarella MA, Valberg PA. Carbon black vs. black carbon and other airborne materials containing elemental carbon: physical and chemical distinctions. Environmental Pollution. 2013 Oct 1;181:271-86.
Chuang HC, Jones T, Chen Y, Bell J, Wenger J, Berube K. Characterization of airborne particles and associated organic components proceed from increase burning. Analytical Bioanalytical Chemistry. 2011;401(10):3095-3102.
Cain JP, Gassman PL, Wang H, Laskin A. Micro-FTIR study of soot chemical composition evidence of aliphatic hydrocarbons on nascent soot surfaces. Physical Chemistry Chemical Physics. 2010;12(20):5206-18.
Niessner R. The many faces of soot: characterization of soot nanoparticles produced by engines. Angewandte Chemie Int Ed. 2014 Nov 10;53(46):12366-79.
Watson AY, Valberg PA. Carbon black and soot: two different substances. AIHAJ. 2001;62(2):218-28.
Victor DG, Ramanathan V, Zaelke D. Air pollution: harmful soot spurs climate-policy action. Nature. 2014 Dec 31;517(7532):21.
Goto D. Modeling of black carbon in Asia using a global-to-regional seamless aerosol-transport model. Environmental pollution. 2014 Dec 1;195:330-5.
Niranjan R, Thakur AK. The toxicological mechanisms of environmental soot (black carbon) and carbon black: Focus on Oxidative stress and inflammatory pathways. Frontiers Immunol. 2017 Jun 30;8:763.
Nwafor A, Maduako KO. Visual acuity of Nigerians in two distinct and contracting environment in Rivers State in the Niger Delta. J Appl Sci Envirnon Mgt. 2001;5(2):47-50.
Kindzierski WB. Importance of human environmental exposure to hazardous air pollutants from gas flares. Environmental Reviews. 1999 Apr 20;8(1):41-62.
Okoro AM, Ani EJ, Ibu JO, Akpogomeh BA. Effect of petroleum products inhalation on some haematological indices of fuel attendants in Calabar metropolis, Nigeria. Nigerian J Physiol Sci. 2006;21(1-2).
Ovuru SS, Ekweozor IK. Haematological changes associated with crude oil ingestion in experimental rabbits. African J Biotechnol. 2004;3(6):346-8.
Owu DU, Udoete UB, Azah N, Eyong EU. Effect of bonny light crude oil on some haematological parameters of guinea pigs. Biokemistri. 2005 Dec;17(2):165-70.
Lewis GF, Steiner G. Hypertriglyceridemia and its metabolic consequences as a risk factor for atherosclerotic cardiovascular disease in non‐insulin‐dependent diabetes mellitus. Diabetes/metabolism reviews. 1996;12(1):37-56.
Loh KC, Thai AC, Lui KF, Ng WY. High prevalence of dyslipidaemia despite adequate glycaemic control in patients with diabetes. Annals Academy Med Singapore. 1996 Mar;25(2):228-32.