Serum magnesium levels in type 2 diabetes
DOI:
https://doi.org/10.18203/2320-6012.ijrms20160682Keywords:
Serum magnesium, Type 2 diabetes, Glycemic control, HbA1cAbstract
Background: Several studies undertaken in different parts of the world have shown that hypomagnesemia occur at an increased frequency among patients with type 2 diabetes compared with their counterparts without diabetes. As current data suggest adverse outcomes in association with hypomagnesemia, it is prudent to monitor magnesium routinely in this patient population and treat the condition whenever possible. Therefore, this study was undertaken to determine the serum magnesium levels in type 2 diabetes in this part of our country.
Methods: A cross-sectional study was conducted in 100 subjects, 50 diabetics without complications (group I), 50 diabetics with complications (group II) and 100 normal healthy controls (group III). Blood sugar levels, magnesium, HbA1C (%), cholesterol and triglyceride level were measured.
Results: Serum magnesium levels were found low in study group as compared to control group. A significant correlation between HbA1C and magnesium levels was seen. The patients with diabetic complications have significantly higher values of serum cholesterol and triglycerides.
Conclusions: Hypomagnesemia in type 2 diabetes was associated with poor glycemic control and with increased frequency of long term complications.
References
Paolisso G, Scheen A, D’Onfrio F, Lefebvre P. Magnesium and glucose. Diabetologia. 1990;33:511-4.
Hatwal A, Gujral AS, Bhatia RP, Agarwal JK, Bajpai HS. Association of hypomagnesemia with diabetic retinopathy. Acta Ophtalmol. 1989; 67:714-6.
Sasaki S, Oshima T, Matsuura H. Abnormal magnesium status in patients with cardiovascular diseases. ClinSci (Colch). 2000;98:175-81.
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. The expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 2002;25:S5-20.
Rude RK. Magnesium deficiency and diabetes mellitus – causes and effects. Postgrad Med J. 1992;92:217-24.
Durlach J, Altura B, Altura BM. Highlights and summary of the 10th Annual French Colloquium on magnesium. Magnesium. 1983;2:330-6.
Lal J, Vasudev K, Kela AK, Jain SK. Effect of oral magnesium supplementation on lipid profile and blood glucose of patients with type 2 diabetes mellitus. JAPI. 2003;51:37-42.
Garfinkel D. Role of magnesium in carbohydrate oxidation. Magnesium. 1988;7:249-61.
Alzaida A, Dinneen SF, Moyer TP, Rizza RA. Effects of insulin on plasma magnesium in noninsulin dependent diabetes mellitus–evidence for insulin resistance. J Clin End ocrinol Metab. 1995;80:1376-81.
Yajnik CS, Smith RF, Hockaday TD, Ward NI. Fasting plasma magnesium concentrations and glucose disposal in diabetes. BMJ. 1984;288:1032-4.
Schlinger JL, Grunenberger F, Maier EA, Simon C, Chabrier G, Leroy MJF. Disturbances of plasma trace elements in diabetes – relations with glycemic control. Presse Med. 1988;17:1076-9.
Nagase N. Hypertension and serum magnesium in the patients with diabetes and coronary heart disease. Hypertens Res. 1996;19:65-68.
