A clinico-epidemiological profile of patients with influenza A H1N1 attending a tertiary care hospital in southern Rajasthan region of India

Yogesh Kumar Singhal, Nitin Kothari


Background: Influenza, commonly referred to as the flu, is an infectious disease caused by RNA viruses of the family Orthomyxoviridae (the influenza viruses). Swine flu cases resurfaced in month of January 2015 in Southern region of India which are continuation of pandemic 2009. Aim of this study is to summaries the clinical and epidemiological factors associated with swine flu as well as to estimate the burden of Influenza A H1N1 (Swine Flu) cases.

Methods: A complete data of all the patients visiting swine flu OPDs, swine flu wards and ICU were maintained for year 2015. Each patient visiting either the swine flu OPD or the swine flu ward, who was suspected clinically to be H1N1 positive were tested for real time PCR.

Results: Out of 1247 samples tested for rt-PCR 491 (39.37%) cases were identified as positive for H1N1. Maximum swine positivity was seen in the age group of 16-30 year i.e. 147 (29.94%). Overall swine positivity was significantly (<0.001) higher in females than male and extremely statistically significant (p<0.0001) higher in rural areas than urban. Cough was the most common clinical symptoms affecting 469(95.52%) patients followed by fever (92.26%) and breathlessness 402(81.87%).

Conclusions: Our study will help epidemiologist and clinician to identify epidemiological factors and clinical picture of swine flu.


Influenza A H1N1, Nasopharyngeal swabs, rt-PCR, Rajasthan outbreak, Throat swabs, Swine flu

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Taubenberger JK, Morens DM. The pathology of influenza virus infections. Annu. Rev. Pathmechdis. Mech. Dis. 2008 Feb 28;3:499-522.

Nobusawa E, Sato K. Comparison of the mutation rates of human influenza A and B viruses. J Virol. 2006 Apr 1;80(7):3675-8.

Matsuzaki Y, Katsushima N, Nagai Y, Shoji M, Itagaki T, Sakamoto M, et al. Clinical features of influenza C virus infection in children. J infectious Dis. 2006 May 1;193(9):1229-35.

Sharma CP, Keerti SS, Kumar A, Gupta MK. Demographic correlates of swine flu cases attending a tertiary care hospital in Rajasthan. Indian J Prev Soc Med. 2012;43:224-8.

Jain S, Kamimoto L, Bramley AM, Schmitz AM, Benoit SR, Louie J, et al. Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009. New England J Medicine. 2009 Nov 12;361(20):1935-44.

Sharma CP, Keerti SS, Kumar A, Gupta MK. Demographic correlates of swine flu cases attending a tertiary care hospital in Rajasthan. Indian J Prev Soc Med. 2012;43:224-8.

Singh M, Sharma S. An epidemiological study of recent outbreak of influenza A H1N1 (Swine Flu) in Western Rajasthan region of India. J Med All Sci. 2013 Aug 31;3(2):48.

Domadia K, Chatterjee IS, Chatterjee SS, Bhuva D, Mehta MN. Clinical-Epidemiological profile of influenza A H1N1 cases at a tertiary care institute of Western India. Indian J Applied Res. 2015;5(10):657-9.

Malkar VR, Joge US, Raut MM. Clinico-epidemiological profile of patients of H1N1 influenza (swine flu) virus infection at a tertiary care hospital in Maharashtra. Int J Biol Med Res. 2012;3(3):2116-20.

Gelotar PS. Epidemiological and Clinical profile of patients with swine flu (Influenza A, H1N1) attending Guru Govindsingh Government Hospital, Jamnagar, India. J Res Med Den Sci. 2013;1:1-6.

Kashinkunti MD, Gundikeri SK, Dhananjaya M. Study of clinical profile of patients with H1N1 influenza in a teaching hospital of North Karnataka. Diabetes. 2013;11:50.

Humne AY, Thakre SB, Ughade SM, Rathod PG, Thakre SS, Chavan AB. An epidemiological investigation of influenza like illness (ILI) to confirm the A H1N1 among patients admitted to secondary and tertiary care hospital of Nagpur, central India. Int J Sci Res Publications. 2009;3(8):383-8.

Vyas C, Somani J, Patel D. Clinical and Epidemiological Profile of hospitalised H1N1 Cases: Comparison of Pandemic, Post pandemic and Recent epidemic period. J Med Sci. 2013;2(1):26-32.