A histopathological study of sebaceous neoplasms and related lesions at a tertiary care centre

Swagata Dowerah, Munmun Harlalka


Background: Sebaceous lesions have intrigued pathologists and dermatologist alike causing a great deal of diagnostic confusion. Tumors and tumor like conditions of the sebaceous glands include sebaceous hyperplasia, Nevus sebaceus of Jadassohn, sebaceous adenoma, sebaceoma and sebaceous carcinoma.

Methods: A three-year study of all lesions with sebaceous differentiation was carried out in the histopathology section of a tertiary care hospital to study the spectrum of lesions showing sebaceous differentiation. Patient records were noted, and paraffin embedded sections stained with haematoxylin and eosin were examined for histopathological diagnosis. Clinical correlation was done in all the cases.

Results: The spectrum of lesions encountered included sebaceous carcinoma, Nevus sebaceous, sebaceous hyperplasia, sebaceous adenoma among others. Eyelid was the most common site followed by scalp. Clinicopathological correlation was found to be poor in these lesions with clinical examination failing to correctly identify most of the cases.

Conclusions: Sebaceous neoplasms were seen to be rarer in our population as compared to other adnexal tumors. Histopathology, in the presence of typical features, is the mainstay of diagnosis with immunohistochemistry aiding in certain doubtful cases.


Adnexal tumors, Histopathology, Sebaceous lesions

Full Text:



Urban FH, Winkelmann RH. Sebaceous malignancy. Arch Derm. 1961;84:63-72.

Manonukul J, Kajornvuthidej S. Sebaceous Neoplasms in Siriraj Hospital, Mahidol University: A 9-Year-Retrospective Study. 2010;93(8):979.

Nelson BR, Hamlet KR, Gillard M, Railan D, Johnson TM. Sebaceous carcinoma. J Am Acad Dermatol. 1995;33(1):1-15.

Carlson JW, McGlennen RC, Gomez R, Longbella C, Carter J, Carson LF. Sebaceous carcinoma of the vulva: a case report and review of the literature. Gynecol Oncol. 1996 Mar 1;60(3):489-91.

Oppenheim AR. Sebaceous carcinoma of the penis. Arch Dermatol. 1981;117(5):306-7.

Ansai S, Hashimoto H, Aoki T, Hozumi Y, Aso K. A histochemical and immunohistochemical study of extra-ocular sebaceous carcinoma. Histopathol. 1993;22:127-133.

Muthusamy K, Halbert G, Roberts F. Immunohistochemical staining for adipophilin, perilipin and TIP47. J Clin Pathol. 2006;59(11):1166-70.

Prieto VG, Shea CR, Celebi JT, Busam KJ. Adnexal Tumors. In KJ B. Dermatopathology.: Saunders Elsevier; 2010:429-430.

Tumolke JR. Skin-Tumors and conditions. In Rosai and Ackerman's Surgical Pathology. 9th ed.: Elsevier; 2011:147.

Rulon DB, Helwig EB. Cutaneous sebaceous neoplasms. Cancer. 1974;33(1):82-102.

Ahmed TSS, Priore JD, Seykora JT. Tumors of the epidermal appendages. In DE E, editor. Lever's Histopatholofy of the Skin. 10th ed.: Wolter Kluwer; 2011:874.

Dhume VM, Kavishwar VS, Aidasani S. Histopathological spectrum of tumefactive lesions of sebaceous gland. 2017;6(10):22-4.

Nair PS. A clinico-pathological study of skin appendageal tumours. Indian J Dermatol Venereol Leprol. 2008;79:550.