A study of cardiological autonomic neuropathy in Type 2 Diabetes Mellitus with reference to QT interval for its diagnosis

Authors

  • Lakshmi Priya Inapakolla Department of General Medicine, Konaseema Institute of Medical Science, Amalapuram, Andhra pradesh, India
  • Ramgopal Teja Kotla Department of General Medicine, Konaseema Institute of Medical Science, Amalapuram, Andhra pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20192880

Keywords:

Autonomic neuropathy, Type 2 diabetes mellitus, QT interval

Abstract

Background: Presence of cardiac autonomic neuropathy (CAN) is responsible for silent myocardial infarction and sudden death in diabetics. Hence recognizing cardiac dysautonomia early, which is asymptomatic will help to delay or arrest its progression.

Methods: A cross-sectional study to evaluate the Prevalence of Cardiovascular Autonomic Neuropathy in Type 2 diabetes and correlate it with duration of Diabetes and to investigate the relationship between cardiac autonomic dysfunction and corrected QT interval.

Results: In the study population, the prevalence of definite CAN was 8%, 24% and 58% in group A, B and C respectively. The prevalence of definite CAN increases with increase in duration of diabetes. P value <0.001 significant.

Conclusions: A significant correlation is present between Cardiovascular autonomic dysfunction and QTc prolongation. QTc interval in the ECG can be used to diagnose Cardiovascular autonomic neuropathy with a reasonable sensitivity and specificity.

References

Nihal T, Vasan S, Bhatt R. A practical approach to Diabetes Mellitus, 2007. Available at: https://archive.org/details/APracticalGuideToDiabetesMellitus7thEdgnv64.

Munichoodappa C. Epidemiology and burden of type 2 diabetes mellitus, Bangalore. Type. 2002;2:13.

Vinik AI, Maser RE, Mitchell BD, Freeman R. Diabetic autonomic neuropathy. Diab Care. 2003;26(5):1553-79.

Chen HS, Hwu CM, Kuo BI, Chiang SC, Kwok CF, Lee SH, et al. Abnormal cardiovascular reflex tests are predictors of mortality in type 2 diabetes mellitus. Diab Med. 2001;18(4):268-73.

Vinik AI, Ziegler D. Diabetic cardiovascular autonomic neuropathy. Circul. 2007;115(3):387-97.

Low PA, Walsh JC, Huang CY, McLeod JG. The sympathetic nervous system in diabetic neuropathy: a clinical and pathological study. Brain. 1975;98(3):341-56.

Maser RE, Mitchell BD, Vinik AI, Freeman R. The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis. Diab Care. 2003;26(6):1895-901.

Mohan V, Sastry NG, Premalatha G. Autonomic dysfunction in non‐insulin‐dependent diabetes mellitus and fibrocalculous pancreatic diabetes in South India. Diab medicine. 1996;13(12):1038-43.

Toyry JP, Niskanen LK, Mantysaari MJ, Lansimies EA, Uusitupa MI. Occurrence, predictors, and clinical significance of autonomic neuropathy in NIDDM: ten-year follow-up from the diagnosis. Diab. 1996;45(3):308-15.

Pappachan JM, Sebastian J, Bino BC, Jayaprakash K, Vijayakumar K, Sujathan P, et al. Cardiac autonomic neuropathy in diabetes mellitus: prevalence, risk factors and utility of corrected QT interval in the ECG for its diagnosis. Postgrad Med J. 2008;84(990):205-10.

Downloads

Published

2019-06-28

How to Cite

Inapakolla, L. P., & Kotla, R. T. (2019). A study of cardiological autonomic neuropathy in Type 2 Diabetes Mellitus with reference to QT interval for its diagnosis. International Journal of Research in Medical Sciences, 7(7), 2574–2577. https://doi.org/10.18203/2320-6012.ijrms20192880

Issue

Section

Original Research Articles