DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20192505

Pulmonary function test in patients of type 2 diabetes mellitus

Amit Agarwal, Ankit Grover, Amresh Agarwal

Abstract


Background: We are today witnessing a pandemic of diabetes mellitus (DM), globally and nationally. DM and its complications have become the most important contemporary and challenging health problems. Diabetes is not associated with any specific pulmonary symptom and hence periodic screening for lung disease is not done in diabetic patients. However, an extensive microvascular circulation and an abundant connective tissue in the lung raise the possibility that the lung may also be a target organ in diabetic patients. The aim and objectives were to study the pulmonary function of individual with type 2 diabetes mellitus patients by performing spirometry.

Methods: Study included non-smoker diabetic patients, who had no history of respiratory disease, were selected for this study and undergone pulmonary function test by spirometry. The study was conducted at department of General Medicine Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, India.

Results: Present study, author found that there was significant derangement in the spirometric readings in the diabetic patients. The FEV1/FVC values further declines as the duration of diabetes increased.

Conclusions: Spirometric values (FVC, FEV1, FEV1/FVC) were consistently lower in subjects with type 2 diabetes mellitus. The effect on FVC predicted % was found to be more pronounced in subjects whose duration of DM was more than 5 years.


Keywords


Diabetes mellitus, FEV1, FVC, FEV1/FVC, Spirometry

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References


World Health Organization. Diabetes: Fact sheet N 312, 2011. Available at: http://www.who.int/mediacentre/factsheets/fs312/en/. Accessed 04 April 2015.

Meo SA. Diabetes mellitus: health and wealth threat. Int J Diab Mellitus. 2009;1(1):42.

James RG, Alberti KGMM, Mayer BD, Ralph AD, Allan D, Steven G, et al. Report on the expert committee on the diagnosis and classification of diabetes mellitus. Diab Care. 2002;25:S5-20.

Arnalich F, Hernanz A, Maderuelo LD, Pena JM, Camacho J, Madero R, et al. Enhanced acute-phase response and oxidative stress in older adults with type II diabetes. Hormone Metab Res. 2000;32(10):407-12.

Sandler M. Is the lung a “target organ” in diabetes mellitus?. Arch Int Med. 1990;150(7):1385-8.

Sandler M, Bunn AE, Stewart RI. Cross-section study of pulmonary function in patients with insulin-dependent diabetes mellitus. Am Rev Respiratory Dis. 1987;135(1):223-9.

Hsia CC, Raskin P. Lung involvement in diabetes. Does it matter?. Diab Care. 2008;31:828-29.

Farina J, Furio V, Acenero FMJ, Muzas MA. Nodular fibrosis of the lung in diabetes mellitus. Virchows Arch. 1995;427:61-3.

Innocenti F, Fabbri A, Anichini R, Tuci S, Pettina G, Vannucci F, et al. Indications of reduced pulmonary function in type 1 (insulin-dependent) diabetes mellitus. Diabetes Res Clin Pract. 1994;25:161-8.

Ljubic S, Metelko Z, Car N, Roglic G, Drazic Z. Reduction of diffusion capacity for carbon monoxide in diabetic patients. Chest. 1998;114:1033-5.

Soulis T, Thallas V, Youssef S, Gilbert RE, McWilliam BG, McIntosh MRP, et al. Advanced glycation end products and their receptors co-localise in rat organs susceptible to diabetic microvascular injury. Diabetol. 1997;40:619-28.

Weir DC, Jennings PE, Hendy MS, Barnett AH, Burge PS. Transfer factor for carbon monoxide in patients with diabetes with and without microangiopathy. Thorax. 1988;43:725-6.

Vracko R, Thorning D, Huang TW. Basal lamina of alveolar epithelium and capillaries: quantitative changes with aging and diabetes mellitus. Am Rev Respir Dis. 1979;120:973-83.

Villa MP, Bernardi F, Cicognani A, Salardi S, Zapulla F. Bronchial reactivity in diabetic patients: Relationship to duration of diabetes and degree of glycemic control. Am J Dis Child. 1988;142:726-9.

Ruppel GL. Pulmonary function testing. trends and techniques. Respir Care Clin North Am. 1997;3:155-81.

McKay, Ray T, Horvath Edward. Pulmonary function testing in industry. In: Carl Zenz O, Dickerson Bruca, Horvath Edward P, editors. Occupational medicine. London: Mosby; 1984: 229.

Christine Jenkinsa. Spirometry performance in primary care: the problem, and possible solutions. Primary Care Respir J. 2009;18(3):128-9.

Meo SA, Al Drees AM, Arif M, Al-Rubean K. Lung function in type 2 Saudi diabetic patients. Saudi Med J. 2006;27(3):338-43.

Hsia CC. Recruitment of lung diffusing capacity: update of concept and application. Chest. 2002;122:1774-83.

Marvisi M, Lino Bartolini L, del Borrello P, Brianti M, Marrani G, Guariglia A, et al. Pulmonary Function in non-insulin-dependent diabetes mellitus. Respiration. 2001;68:268-72.

Cavalheri V. Effects of arm bracing on the respiratory muscle strength and the pulmonary function in patients with chronic obstructive pulmonary disease. Rev Port Pneumol. 2010;16(6)88791.

Davis WA, Knuiman M, Kendall P, Grange V, Davis TM. Glycemic exposure is associated with reduced pulmonary function in type 2 diabetes: The Fremantle Diabetes Study. Diabetes Care. 2004;27:752-7.

Meo SA, AlDrees AM, Shah SF, Arif M, AlRubean K. Lung function in type 1 Saudi diabetic patients. Saudi Med J. 2005;26:1728-33.

Lange P, Groth S, Kastrup J, Mortensen J, Appleyard M, Nyboe J, Jensen G, Schnohr P. Diabetes mellitus, plasma glucose and lung function in a cross-sectional population study. Europ Resp J. 1989;1:2(1):14-9.

Boulbou MS, Gourgoulianis KI, Klisiaris VK, Tsikrikas TS, Stathakis NE, Molyvdas PA. Diabetes mellitus and lung function. Med Princ Pract. 2003;12(2):87-91.

Asanuma Y. Characteristics of pulmonary function in patients with DM. Diab Res Clin Pract. 1985;1(2):95-101.

Cazzato S, Bernardi F, Salardi S, Tassinari D, Corsini I, Ragni L, et al. Lung function in children with diabetes mellitus. Pediatr Pulmonol. 2004;37(1):17-23.

Makkar P, Gandhi M, Agrawal RP, Sabir M, Kothari RP. Ventilatory pulmonary function tests in type 1 diabetes mellitus. J Assoc Physicians India. 2000;48(10):962-6.

Rosenecker J, Hofler R, Steinkamp G, Eichler I, Smaczny C, Ballmann M, et al. Diabetes mellitus in patients with cystic fibrosis: the impact of diabetes mellitus on pulmonary function and clinical outcome. Eur J Med Res. 2001;276(8):345-50.

Kanya Kumari DH, Nataraj SM, Devaraj HS. Correlation of duration of diabetes and pulmonary function tests in type 2 diabetes mellitus patients. Int J Biol Med Res. 2011;2(4):1168-70.