DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20192549

Is vitamin C able to reduce hyperuricemia

Hantono S.

Abstract


Hyperuricemia is defined as high levels of blood uric acid, the product of purine metabolism, which can form uric acid crystals and lead to become gout. Gout is a systemic disease that results from chronic elevation of uric acid levels above the threshold point and form the deposition of monosodium urate (MSU) crystals in tissues, mainly in and around the joints forming tophi. The impact of gout and its associated conditions can cause deformity, morbidity and mortality. Vitamin C is shown to has beneficial effect in lowering serum uric acid level in hyperuricemia patients with unknown mechanism. But it is still debatable whether using or not using and the dose of vitamin C because giving large doses also had no effect on serum uric acid concentration, uric acid excretion and clearance by the kidney, and even can cause adverse effects.


Keywords


Dosage, Hyperuricemia, Gout, Uric acid, Uricosuric effects, Vitamin C

Full Text:

PDF

References


Ming J, Fan Y, Irene Y, Ying Y, Jin JL, Hong W, et al. Uric acid, hyperuricemia and vascular diseases. Front Biosci. 2012;17:656-69.

Gaafar R, Mohsen E, Thomas B. Hout: an old disease in new perspective. J Adv Res. 2017;8(5):495-511.

Pascual E, Sivera F. Time required for disappearance of urate crystals from synovial fluid after successful hypouricaemic treatment relates to the duration of gout. Ann Rheum Dis. 2007;66(8):1056-8.

Zhu Y, Pandya BJ, Choi HK. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008. Arthritis Rheum. 2011;63(10):3136-41.

Hastuti VN, Murbawani EA, Wijayanti HS. Relation of total protein intake and soy protein to uric acid levels in the blood of menopausal women. J Nutrition Coll, 2018. Available at: https://ejournal3.undip.ac.id/index.php/jnc/article/view/20823.

Talia FI, Svetlana Krasnokutsky, Michael HP. Recent advances in understanding and managing gout. F1000Res. 2017;6:247.

Huang HY, Apper LJ, Choi MJ, Gelber AC, Charleston J, Norkus EP, et al. The Effects of vitamin C supplementation on serum concentration of uric acid: results of a randomized controlled trial. Arthritis Rheum. 2005;52(6):1843-7.

Choi HK, Mount DB, Reginato AM. Pathogenesis of gout. Ann Intern Med. 2005;143:499-516.

Choi HK. A prescription for lifestyle change in patients with hyperuricemia and gout. Curr Opin Rheumatol. 2010;22:165-72.

Stein HB, Hasan A, Fox IH. Ascorbic acid-induced uricosuria: a consequency of megavitamin therapy. Ann Intern Med. 1976;84:385-58.

Riches PL, Wright AF, Ralston SH. Recent insights into the pathogenesis of hyperuricaemia and gout. Hum Mol Genet. 2009;18:R177-84.8.

Feigelson P. The inhibition of xanthine oxidase in vitro by trace amounts of l-ascorbic acid. J Biol Chem. 1952;197:843-50.

Chaudhary K, Malhotra K, Sowers J, Aroor A. Uric acid-key ingredient in the recipe for cardiorenal metabolic syndrome. Cardioren Med. 2013;208-20.

Matsuo H, Nakayama A, Sakiyama M. ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload. Sci Rep. 2014;4:3755.

Mandal A, Mount DB. The molecular physiology of uric acid homeostasis. Annu Rev Physiol. 2014;77:323-45.

Clémençon B, Lüscher BP, Fine M. Expression, purification, and structural insights for the human uric acid transporter, GLUT9, using the Xenopus laevis oocytes system, PLoS One. 2014;e108852.

Su J, Wei Y, Liu M. Anti-hyperuricemic and nephroprotective effects of Rhizoma Dioscoreae septemlobae extracts and its main component dioscin via regulation of mOAT1, mURAT1 and mOCT2 in hypertensive mice. Arch Pharm Res. 2014;37:1336-44.

Wu XH, Zhang J, Wang SQ, Yang VC, Anderson S, Zhang YW. Riparoside B, et al. Two steroidal glycosides from Smilax riparia, resist to hyperuricemia based on URAT1 in hyperuricemic mice. Phytomed. 2014;21:1196-201.

Paul BJ, Anoopkumar K, Krishnan V. Asymptomatic hyperuricemia: is it time to intervene?. Clin Rheumatol. 2017;36:2637-44.

Li L, Yang C, Zhao Y. Is hyperuricemia an independent risk factor for new-onset chronic kidney disease?: a systematic review and meta-analysis based on observational cohort studies. BMC Nephrol. 2014;15:122.

Johnson RJ, Nakgawa T. Uric acid and chronic kidney disease: which is chasing which?. Nephrol Dial Transplant. 2013;28(9):2221-8.

Mikuls, TR, Farrar JT, Bilker WB, Fernandes S, Schumacher HR, et al. Gout epidemiology: results from the UK General Practice Research Database, 1990-1999. Ann Rheum Dis. 2005;64:267-72.

Annemans L, Spaepen E, Gaskin M. Gout in the UK and Germany: prevalence, comorbidities and management in general practice, 2000-2005. Ann Rheum Dis. 2007;67:960-6.

Harris MD, Siegel LB, Alloway JA. Gout and hyperuricemia. Am Fam Physician. 1999;59(4):925-34.

Tausche AK, Tim LJ, Schröder HE, Stefan RB, Martin A, Ulf ML. Gout-Current Diagnosis and Treatment. Dtsch Arztebl Int. 2009;106(34-35):549-55.

Choi HK, Atkinson K, Karlson EW, Willett WC, Curhan G. Purine-rich foods, dairy and protein intake, and the risk of gout in men. N Engl J Med. 2004;350(11):1093-103.

Lykkessfeldt J, Alexander JM, Frei B. Vitamin C. Adv Nutr. 2014;5(1):16-8.

Iqbal K, Khan A, Khattak M. Biological significance of ascorbic acid (vitamin C) in human health-a review. Pak J Nutrition. 2014;3(1):5-13.

Hall AP, Barry PE, Dawber TR, McNamara PM. Epidemiology of gout and hyperuricemia: a long-term population study. Am J Med. 1967;42:27-37.

Conaghan PG, Day RO. Risks and benefits of drugs used in the management and prevention of gout. Drug Saf. 1994;11:252-8.

Gelber AC. A little citrus might go a long way!. J Rheumatol. 2008;35:1692-4.

Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G. Purine-rich foods, dairy and protein intake, and the risk of gout in men. N Engl J Med. 2004;350:1093-103.

Berger L, Gerson CD, Yu TF. The effect of ascorbic acid on uric acid excretion with a commentary on the renal handling of ascorbic acid. Am J Med. 1977;62:71-6.

Xiang G, Gary C, John PF, Alberto A, Hyon KC. Vitamin C Intake and Serum Uric Acid Concentration in Men. J Rheumatol. 2008;35(9):1853-8.

Kakutani HM, Kadoya M, Okazaki H, Kurajoh M, Shoji T, Koya H, et al. Nonpharmacological management of gout and hyperuricemia: hints for better lifestyle. Am J Lifestyle Med. 2015;11(4):321-9.

Choi HK, Gao X, Curhan G. Vitamin C intake and the risk of gout in men: a prospective study. Arch Intern Med. 2009;169(5):502-7.

Juraschek SP, Miller ER, Gelber AC. Effect of oral vitamin C supplementation on serum uric acid: a meta-analysis of randomized controlled trials. Arthritis Care Res. 2011;63:1295-306.

Bae J, Shin DH, Chun BY, Choi BY, Kim MK, Shin MH, et al. The effect of vitamin C intake on the risk of hyperuricemia and serum uric acid level in Korean Multi-Rural Communities Cohort. Joint Bone Spine. 2014;81:513-9.

Firas SA, Abrar H, Al-Hebshi, Haya DAE, Mohammed AA. Vitamin C Supplementation and Hyperuricemia: Fact or Hoax?, 2016. Available at: https://www.semanticscholar.org/paper/Vitamin-C-Supplementation-and-Hyperuricemia%3A-Fact-Azzeh-Al-Hebshi/7e62cf035504d0430faf4f992593a90b6c19574d.

Levy G, Cheetham TC. Is it time to start treating asymptomatic hyperuricemia?. Am J Kidney Dis. 2015;66(6):933-5.

Ramirez MEG, Bargman JM. Treatment of asymptomatic hyperuricemia in chronic kidney disease: a new target in an old enemy-a review. J Adv Res. 2017;8(5):551-4.

Biniaz V, Tayebi A, Ebadi A, Sadeghi SM, Einollahi B. Effect of vitamin C supplementation on serum uric acid in patients undergoing hemodialysis: a randomized controlled trial. Iran J Kidney Dis. 2014;8(5):401-7.

Stamp LK, O’Donnell JL, Frampton C, Drake JM, Zhang M, Chapman PT. Clinically insignificant effect of supplemental vitamin C on serum urate in patients with gout; a pilot randomised controlled trial. Arthritis Rheum. 2013;65:1636-42.

Taylor EN, Stampfer MJ, Curhan GC. Dietary factors and the risk of incident kidney stones in men: new insights after 14 years of follow-up. J Am Soc Nephrol. 2004;15(12):3225-32.

Ferraro PM, Curhan GC, Gambaro G, Taylor EN. Total, dietary, and supplemental vitamin c intake and risk of incident kidney stones. Am J Kidney Dis. 2016;67(3):400-7.

Mitch WE, Johnson MW, Kirshenbaum JM, Lopez RE. Effect of large oral doses of ascorbic acid on uric acid excretion by normal subjects. Clin Pharmacol Ther. 1981;29(3):318-21.

Dincer HE, Dincer AP, Levinson DJ. Asymptomatic hyperuricemia: to treat or not to treat. Cleve Clin J Med. 2002;69(8):594,597,600-2.

Zhang W, Doherty M, Bardin T, Pascual E, Barskova V, Conaghan P, et al. EULAR evidence-based recommendations for gout. Part II: management: report of a task force of the EULAR standing committee for international clinical studies including therapeutics (ESCISIT). Ann Rheum Dis. 2006;65:1312-24.

Binoy JP, Anoopkumar K, Krishnan V. Asymptomatic hyperuricemia: is it time to intervene?. Clin Rheumatol. 2017;36:2637-44.

Engel B, Just J, Bleckwenn M, Weckbecker K. Treatment options for gout. Dtsch Arztebl Int. 2017;114(13):215-22.