DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20192545

Rare mimicker of transient ischaemic attacks: the syndrome of transient headache and neurological deficits with cerebrospinal luid lymphocytosis

Philo Hazeena, Naga Karthik Vanukuri, Shankar V.

Abstract


The syndrome of transient headache and neurologic deficits associated with cerebrospinal fluid lymphocytosis (HaNDL) is a benign and self limiting disorder characterized by 1 or more episodes of severe headache and transient neurologic deficits with lymphocytic pleocytosis in the cerebrospinal fluid. We report a case of a 30-year-old male who presented with four episodes of headache followed by hemi paresis and hemisensory loss in a week the patient was completely asymptomatic in between each episode of headache with neurological deficits. Persistent serial imaging to visualize the brain were normal with evidence of cerebrospinal fluid lymphocytosis, which lead to the diagnosis of HaNDL. We need to advocate a high degree of suspicion for HaNDL in the background of strong clinical history and findings, when imaging is normal.

Keywords


HaNDL, TIA

Full Text:

PDF

References


Pascual J, Valle N. Pseudomigraine with lymphocytic pleocytosis. Curr Pain Headache Rep. 2003;7:224-8.

Kürtüncü M, Kaya D, Zuliani L, Erdağ E, İçöz S, Uğurel E, et al. CACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid pleocytosis (HaNDL). Cephalalgia. 2013;32:123-9.

Gómez-Aranda F, Canadillas F, Martí-Massó JF, Díez-Tejedor E, Serrano PJ, Leira R, et al. Pseudomigraine with temporary neurological symptoms and lymphocytic pleocytosis: a report of 50 cases. Brain. 1997;120:1105-13.

Bolay H, Reuter U, Dunn AK. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med. 2002;8:136-42.

Berg MJ, Williams LS. The transient syndrome of headache with neurologic deficits and CSF lymphocytosis. Neurol. 1995;45:1648.

Cifelli A, Vaithianathar L. Syndrome of transient Headache and Neurological Deficits with cerebrospinal fluid Lymphocytosis (HaNDL). BMJ case reports. 2011 Jan 1;2011:bcr0320102862.