Relationship between platelet-lymphocyte ratio and tumour infiltrating lymphocyte on metastatic in breast cancer patient

Indro Wibowo Sejati; Ida Bagus Tjakra Wibawa Manuaba; Putu Anda Tusta; Gede Budhi Setiawan

doi:10.18203/2320-6012.ijrms20192153

Authors

Indro Wibowo Sejati Department of General Surgery, Sanglah General Hospital, Faculty of Medicine Udayana University, Denpasar, Bali, Indonesia
Ida Bagus Tjakra Wibawa Manuaba Department of General Surgery, Sanglah General Hospital, Faculty of Medicine Udayana University, Denpasar, Bali, Indonesia
Putu Anda Tusta Department of General Surgery, Sanglah General Hospital, Faculty of Medicine Udayana University, Denpasar, Bali, Indonesia
Gede Budhi Setiawan Department of General Surgery, Sanglah General Hospital, Faculty of Medicine Udayana University, Denpasar, Bali, Indonesia

DOI:

https://doi.org/10.18203/2320-6012.ijrms20192153

Keywords:

Breast cancer, Metastasis, PLR, TIL

Abstract

Background: Platelet-lymphocyte ratio (PLR) is known associated with the prognosis of distant metastatic breast cancer. Tumor-infiltrating lymphocyte (TIL) in breast cancer also associated with the prognosis of distant metastatic breast cancer. In this study, we will examine the relationship between PLR and TIL, in association with the metastatic incidence in breast cancer.

Methods: This research is a retrospective, analytic, cross-sectional study. Data was taken from medical records of breast cancer patients at Sanglah general hospital. Samples were taken by nested sampling by selecting all breast cancer patients from the period of January 1^st, 2017, to December 31^st, 2018, which had complete medical record data, with total sample 211. The PLR and TIL were calculated and analyzed in relation to metastasis incidence of breast cancer.

Results: The sample characteristics were sorted by age, education, occupation, the area of origin, menstrual status, breast cancer staging, breast cancer subtype, TIL levels, lymphovascular invasion (LVI) status, metastatic status, and breast cancer grading. The data were analyzed to know the association of PLR, TIL, confounding factors in relation to metastatic incidences. In the sample group with PLR ≥ 156 10µ /µL, there were 22.9% cases of metastases (p = 0.002). The sample group at low TIL had metastatic event 12.5% with (p=0.442).

Conclusions: PLR was associated with higher metastasis in breast cancer patients and low TIL had no association with breast cancer metastasis.

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References

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