Correlation cyclooxygenase-2 expression and histopathological grading in locally advanced breast cancer


  • Yasser Maulidan Department of Surgery, Hasanuddin University, Makassar, South Sulawesi, Indonesia
  • Salman A. Syamsu Department of Surgery, Hasanuddin University, Makassar, South Sulawesi, Indonesia
  • Rudy Thabry Department of Surgery, Mulawarman University, Samarinda, East borneo, Indonesia
  • Zainal Abidin Department of Surgery, Mulawarman University, Samarinda, East borneo, Indonesia



Breast cancer, Cyclooxygenase-2, Histopathological grading


Background: Cyclooxygenase-2 (COX-2) is involved in the carcinogenesis process and tumor progression into cancer. It has been reported recently, there was a COX-2 expression at breast cancer. Patients with a high level of COX-2 expression can have a local recurrence and decrease life expectancy, and an increase of COX-2 expression in tissue likelihood has prognostic value. This study aims to correlation cyclooxygenase-2 (cox-2) expression and histopathological grading in locally advanced breast cancer patient in AW Sjahranie Hospital in Samarinda city.

Methods: This study was an observational study with crossectional design to analysis the correlation COX-2 expression and histopathological grading in patients with locally advanced breast cancer and using data analysis with the Chi-Square test.

Results: The results showed that the correlation was not significant (P>0.05), where there was no correlation of COX-2 expression with histopathological grading (P=0.221) and there was no correlation with the last condition of patients (P=0.61). Although patients with breast cancer high grade and moderate grade percentages were significantly higher in positive COX-2 than in COX-2 negative expression.

Conclusions: There were no correlation between COX-2 expression and histopathological grading and there was no significant relationship between COX-2 expression and the last condition, as evidenced by the statistical test results showing that the differences were not significant.


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How to Cite

Maulidan, Y., Syamsu, S. A., Thabry, R., & Abidin, Z. (2019). Correlation cyclooxygenase-2 expression and histopathological grading in locally advanced breast cancer. International Journal of Research in Medical Sciences, 7(7), 2595–2598.



Original Research Articles