Therapeutic alternatives for the prevention of intra peritoneal adhesions

Authors

  • José Ángel Barajas Colón Department of Angiology and Vascular Surgery, Regional Hospital No.1 Dr. Carlos Mc Gregor Sánchez Navarro, IMSS, CDMX, Mexico
  • Gabriela Rubio Nieva Department of Medicine, Faculty of Medicine, UNAM, CDMX, Mexico
  • Alan Isaac Valderrama Treviño Department of Experimental Immunotherapy and Tissue Engineering, Faculty of Medicine, UNAM, CDMX, Mexico
  • Luis Rodrigo Carazo Quiroz Department of Plastic and Reconstructive Surgery, CMNSXXI, IMSS, CDMX, Mexico
  • Juan Pablo Espinoza Torres Department of Paediatric Plastic and Reconstructive Surgery, HGCMN La Raza, IMSS, CDMX, Mexico
  • German Eduardo Mendoza Barrera Department of General Surgery, Creighton University Medical Center, Omaha, Nebraska, USA
  • Rodrigo Banegas Ruiz Department of Hand Surgery and Microsurgery, Rehabilitation Hospital, Luis Guillermo Ibarra, CDMX, Mexico
  • Víctor Manuel Ramos Lojero Department of Sanitary Jurisdiction, Health Services Alvaro Obregon, CDMX, Mexico
  • Baltazar Barrera Mera Department of Physiology, Faculty of Medicine, UNAM, CDMX, Mexico

DOI:

https://doi.org/10.18203/2320-6012.ijrms20192119

Keywords:

Gastrointestinal surgery, Intra peritoneal adhesions, Therapeutic alternatives

Abstract

Intestinal adhesions are bands of fibrous tissue created by the intimate contact of two injured surface tissues; these appear in 93% of the patient undergoing intra-abdominal or gastrointestinal surgery. The comorbidities associated with the formation of adhesions have an impact on quality care offered to patients, leading to an increase in healthcare. Goals of this study was to perform a review that includes different therapeutic alternatives in basic and clinical research to prevent the formation of postoperative abdominal peritoneal adhesions. A bibliographic search was conducted in different databases including Pub med, Medline, Cochrane, science direct, from the years 2000 to 2018 using the keywords: gastrointestinal adhesions, small bowel obstruction, prophylaxis, treatment. Only experimental and clinical articles were selected. The development of peritoneal adhesions in most of the experimental studies occurred with cecal abrasion, studying the effect of biodegradable materials, drugs and gels such as mXG Hydrogel. Nanofiber membranes, agents created with recombinant technology such as periostin antisense oligonucleotide and aerosol applications such as polysaccharide 4DryField PH, are positioned to replace in the future the actual limited mechanical barriers application commonly used in abdominal surgery such as seprafilm and interceed. There are several anti-adhesion agents in experimental phase with different mechanism of action that could be used in the short term to prevent the formation of post-surgical intestinal adhesions. The inclusion of gastrointestinal surgeons in basic research is increasing and necessary with multidisciplinary collaboration. It is expected in short term the study and development of a greater number of materials to minimize tissue trauma and decrease the formation of post-surgical adhesions.

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Published

2019-05-29

How to Cite

Barajas Colón, J. Ángel, Rubio Nieva, G., Valderrama Treviño, A. I., Carazo Quiroz, L. R., Espinoza Torres, J. P., Mendoza Barrera, G. E., Banegas Ruiz, R., Ramos Lojero, V. M., & Barrera Mera, B. (2019). Therapeutic alternatives for the prevention of intra peritoneal adhesions. International Journal of Research in Medical Sciences, 7(6), 2456–2462. https://doi.org/10.18203/2320-6012.ijrms20192119

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Section

Review Articles