Ketamine and propofol: safe for short procedures
DOI:
https://doi.org/10.18203/2320-6012.ijrms20192911Keywords:
Efficacy, Midazolam propofol, Safety, Short procedures, KetamineAbstract
Background: Patients who attend the hospital for any form of operative procedure frequently undergo physical or mental pain and agitation. These patients are extremely anxious. It is important to choose the most appropriate form of anesthesia for induction for the analgesia or sedation. This study examined the safety and effectiveness of the Ketamine and Propofol combination technique for short procedures like D and C, MTP, evacuation and marsupilisation of Bartholin’s abscess.
Methods: The present observational study was carried out in association with the Gynecology and Obstetrics department and Department of Anesthesiology of PDMMC and hospital, Amravati, Maharashtra, India over a period of 3 months from 1st January to 31st March 2019.
Results: In present study, 28 (56%) patients were of 25-40 years age, 14 (28%) patients were of 41-50 years age while 8 (16%) patients were of 51-60 years age. 7 (14%) patients were underweight, 26 (52%) patients had normal BMI, 10 (20%) patients were overweight while 7 (14%) patients were obese. MAP before surgery was 100 ± 12, which decreased to 92±9.2 during operation and increased to 97±19.4 in the postoperative period. Heart rate and arterial SPO2 were not significantly different before, during, and after the operation. Mean VAS score for pain was 5.2±5.1 and the mean Ramsay’s score of sedation was 5.8 ± 0.01. 1 (2%) patient had apnea, 1 (2%) patient had skin reaction, 1 (2%) patient had cough, 1 (2%) patient had agitation while 2 (4%) patient had nausea and vomiting.
Conclusions: Ketamine and Propofol combination technique can be recommended for use in the short procedures safely and effectively.
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References
Bahn EL, Holt KR. Procedural sedation and analgesia: a review and new concepts. Emerg Med Clin North Am. 2005;23(2):503-17.
Symington L, Thakore S. A review of the use of propofol for procedural sedation in the emergency department. Emergency Med J. 2006;23(2):89-93.
White PF, Elig MR. Intravenous anaesthetics. In: Barash PG, editor. Clinical Anaesthesia. 6th ed. China, Lippincott Williams and Wilkins; 2013; 478-500.
Kolawole IK. Ketamine hydrochloride: a useful but frequently misused drug. Nigerian J Surg Res. 2001;3(3):118-25.
Dundee JW, Wyant GM. Intravenous Anasethesia. New York: Churchill Livingstone; 1988: 135–59.
Vuyk J, Sitsen E, Reekers M. Intravenous Anesthetics Miller’s Anesthesia. Philadelphia. 2015;2015:858.
Bryson HM, Fulton BR, Faulds D. Propofol. An update of its use in anaesthesia and conscious sedation. Drugs. 1995;50:513-59.
Burton JH, Miner JR, Shipley ER, Strout TD, Becker C, Thode Jr HC. Propofol for emergency department procedural sedation and analgesia: a tale of three centers. Acad Emerg Med. 2006;13(1):24-30.
Akin A, Esmaoglu A, Guler G, Demircioglu R, Narin N, Boyaci A. Propofol and propofol-ketamine in pediatric patients undergoing cardiac catheterization. Ped Cardiol. 2005;26(5):553-7.
Khutia SK, Mandal MC, Das S, Basu SR. Intravenous infusion of ketamine-propofol can be an alternative to intravenous infusion of fentanyl-propofol for deep sedation and analgesia in paediatric patients undergoing emergency short surgical procedures. Ind J Anaesthesia. 2012;56(2):145.
Ab Rahman NH, Hashim A. Is it safe to use propofol in the emergency department? a randomized controlled trial to compare propofol and midazolam. Inter J Emerg Med. 2010;3(2):105.
Nalini KB, Cherian A, Balachander H. Comparison of propofol and ketamine versus propofol and fentanyl for puerperal sterilization, a randomized clinical trial. J Clin Diagn Res JCDR. 2014;8(5):GC01.
David H, Shipp J. A randomized controlled trial of ketamine/propofol versus propofol alone for emergency department procedural sedation. Ann Emerg Med. 2011;57(5):435-41.
Shah A, Gregory M., Shelley M, Kris L. A blinded, randomized controlled trial to evaluate ketamine/propofol versus ketamine alone for procedural sedation in children. Ann Emerg Med. 2011;57(5):425-433.
Gary A, Riyad BA. Ketamine-propofol combination (ketofol) versus propofol alone for emergency department procedural sedation and analgesia: a randomized double-blind trial. Ann Emerg Med. 2012;59(6):504-12.
Miner JR, Moore JC, Austad EJ, Plummer D, Hubbard L, Gray RO. Randomized, double-blinded, clinical trial of propofol, 1: 1 propofol/ketamine, and 4: 1 propofol/ketamine for deep procedural sedation in the emergency department. Ann Emerg Med. 2015;65(5):479-88.
Nazemroaya B, Majedi MA, Shetabi H, Salmani S. Comparison of propofol and ketamine combination (ketofol) and propofol and fentanyl combination (fenofol) on quality of sedation and analgesia in the lumpectomy: a randomized clinical trial. Adv Biomed Res. 2018;7.
Karki SB, Rajbanshi LK, Arjyal B, Khanal K. Comparison of Anesthetic Properties of Ketofol (ketamine With Propofol) and Propofol in Minor Surgical Procedures. Brit J Heal Sci. 2017;2(3):287-91.
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