Ross syndrome: a case report


  • Manoj Kr. Mahata Department of Neurosurgery, Hyogo College of Medicine, Hyogo, Japan
  • Saikat Ghosh Department of Neurology, Manorama Hospitex, Nadia, West Bengal, India
  • K. C. Ghosh Department of Neurology, CNMC, Kolkata, West Bengal, India
  • R. Bhattacharyya Department of Neurology, CNMC, Kolkata, West Bengal, India
  • G. P. Mondal Department of Neurology, CNMC, Kolkata, West Bengal, India



Anhidrosis, Areflexia, Ross syndrome


Ross syndrome is a rare partial dysautonomic syndrome of unknown aetiology, characterized by segmental hypo/ anhidrosis associated with Holmes-Adie syndrome (tonic pupil and hypo/areflexia). The hypohydrosis or anhydrosis is patchy initially, later it becomes segmental or diffuse. This is due to affection of postganglionic cholinergic parasympathetic and sympathetic fibers involvement. There are a very few cases (approximately 50) have been reported in the literature since its original description. Author report a 22 years old male with classical features of Ross syndrome.


Nolano M, Provitera V, Perretti A, Stancanelli A, Saltalamacchia AM, Donadio V, et al. Ross syndrome: a rare or a misknown disorder of thermoregulation? a skin innervation study on 12 subjects. Brain. 2006;129(8):2119-31.

Luong M, Jomir L, Labauge P, Dandurand M, Meunier L, Stoebner PE. Ross syndrome with sweating anomaly associated with Sjögren syndrome: an infrared thermo-graphic case study. Acta Derm Venereol. 2011;91(1):80-1.

Vasudevan B, Sawhney M, Vishal S. Ross syndrome with ana positivity: A clue to possible autoimmune origin and treatment with intravenous immunoglobulin. Indian J Dermatol. 2010;55(3):274-6.

Nolano M, Provitera V, Donadio V, Stancanelli A, Saltalamacchia A, Caporaso G, et al. Ross syndrome: a lesson from a monozygotic twin pair. Neurol. 2013;80(4):417-8.

Nagane Y, Utsugisawa K. Ross syndrome associated with cytomegalovirus infection. Muscle Nerve. 2008;38(1):924-6.

Sawhney MP, Sharma YK, Singh N. Segmental anhidrosis with hyporeflexia associated with congenital spinal deformity: a Ross's syndrome variant or inverse Horner's syndrome? Indian J Dermatol Venereol Leprol. 2004;70(1):29-32.

Shin RK, Galetta SL, Ting TY, Armstrong K, Bird SJ. Ross syndrome plus: beyond horner, Holmes-Adie, and harlequin. Neurology 2000;55:1841-6.

Diez BM, Rio GI, Dauden E, Arroyo CM, Diez GA. Ross syndrome, an entity included within the spectrum of partial disautonomic syndromes. J Eur Acad Dermatol Venereol. 2005;19(6):729-31.




How to Cite

Mahata, M. K., Ghosh, S., Ghosh, K. C., Bhattacharyya, R., & Mondal, G. P. (2019). Ross syndrome: a case report. International Journal of Research in Medical Sciences, 7(7), 2833–2834.



Case Reports