Pregnancy induced hypertension: lipid peroxidation and antioxidant status


  • Aaliya Shah Department of Biochemistry, SKIMS Medical College and Hospital, Bemina, Srinagar, India
  • Adila Rashid Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, India
  • Mosin S. Khan Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, India
  • Tabassum Parvez Department of Obstetrics and Gynaecology, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, India
  • Mir Kaisar Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, India
  • Syed Mudassar Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, India



Catalase, Hypertension, Oxidative stress, Pregnancy induced hypertension, Superoxide dismutase


Background: Pregnancy is a stressful condition accompanied by a high energy demand and increased oxygen requirement. Oxidative stress has been recognized as a significant factor linked to hypertension. Elucidation of anti-oxidant cascade in patients with pregnancy induced hypertension (PIH). can give insights about the oxidative stress and lead to better management of the condition. It was a prospective case control study to elucidate the parameters of oxidative stress in patients with PIH.

Methods: Levels of Malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) were eludidated using enzyme linked immunosorbent assay (ELISA) in hypertensive mothers and their age matched pregnant and non-pregnant controls to determine the lipid peroxidation and oxidative stress.

Results: A total of four hundred and twenty study subjects were enrolled in the study. Malondialdehyde levels from mothers with hypertension were significantly higher than their age matched pregnant controls. The results indicate that oxidative stress induced by pregnancy induced hypertension manifests as increased lipid peroxidation. Conclusion: There is a decrement in anti-oxidant status reflecting the ineffective scavenging of reactive oxygen species resulting in oxidative damage and tissue injury.

Author Biography

Adila Rashid, Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, India




Scott W. Lipid peroxidation in pregnancy. Hypertension in Pregnancy 1994;13:1-32.

Selyer H. The stress of life. New York, NY: McGraw-Hill; 1959.

Quanonga S and Mukherjea M. Ontogenic profile of some anti-oxidants and lipid per-oxidation in human placental and fetal tissues. Mol. Cell Biochem. 2000;01:11-9.

Clapp JF. Maternal physiological adaption during early human pregnancy. Am. J. Obstet. Gynaecol. 1998;6:1456-60.

Pernoll ML, Metcalfe J, Kovach PA, Wachtel R, Dunham MJ. Ventilation during rest and exercise in pregnancy and post partum. Respir. Physiol. 1975;25:295-300.

Gitto E, Reiter RJ, Karbownik M, Tan DX, Gitto P, Barberi S, et al. Causes of oxidative stress in the pre and perinatal period. Biol. Neonate. 2002;81:146-57.

Alaily AB and Carval KB. Pulmonary ventilation in pregnancy. Br. J. Obstet. Gynaecol. 1978;85:518-25.

John B West. Best in taylors Physiologic Basis of Medical Practise. 12th Ed.; 1991:894-920.

Sies H. Oxidative stress II Oxidants and anti oxidants. Academic Press London; 1991.

Fridovich I. Hypoxia and oxygen toxicity. Adv. Neurol. 1979;26:255-9.

Liochev SI and Friedovich I. Reactive oxygen species and free radical theory of aging. Free Radic. Biol. Med. 1997;23:668-71.

Brown MA, Lindheimer MD, de Swiet M, Van Assche A, Moutquin JM. The classification and diagnosis of hypertensive disorders of pregnancy. Hypertens. Pregnancy. 2001;20:1-9.

Ceriello A. Possible role of oxidative stress in the pathogenesis of hypertension. Diabetes care. 2008;31:S181-4.

Grossman E. Diuretic treatment of hypertension. Diabetes care 2008; 31:185-9.

Nickenig G, Harrison DG. The AT-1 type angiotensin receptor in oxidative stress and atherogenesis. Circulation. 2002;105:393-6.

Jackson EK, Herzer WA, Vyas SJ, Kost CK. Angiotensin II induced renal vasoconstriction in genetic hypertension. J. Pharmacol. Exp. Ther. 1999;291:329-34.

Bergen NE, Timnermans S, Hesselink JR, Lennep JR, Jaddoe VW, Steegers AP. Hypertensive disorders of pregnancy and subsequent maternal cardiovascular health. European J Epidemol. 2018;33:763-71.

Hung TH, Skepper JN, Charnock-Jones DS, Burton GJ. Hypoxia- reoxygenation: a potent inducer of apototic changes in the human placenta and possible etiological factorin pre-eclampsia. Circ. Res. 2002;90:1274-81.

Redman CW, Sargent IL. The pathogenesis of pre-eclampsia. Gynecol. Obstet. Fertil. 2001;29:518-22.

Seeley R, Stephens T, Tate T. Anatomy and Physiology. St. Louis: Mosby; 1995.

Jónsdóttir LS, Arngrímsson R, Geirsson RT, Sigvaldason H, Sigfússon N. Death rates from ischemic heart disease in women with history of hypertension in pregnancy. Acta Obstet. Gynecol. Scand. 1995;74:772-6.

VanWijk MJ, Kublickiene K, Boer K, VanBavel E. Vascular fuction in pre-eclampsia. Cardiovasc. Res. 2000;47:38-48.

Khatri M. Circulating biomarkers of oxidative stress in normal pregnancy and pre-eclampsia and efficacy of anti-oxidant supplementation. International Journal of reproduction, Contraception, Obstetrics and Gynecol. 2013;02:304-10.

Walsh SW. Maternal-placental interactions of oxidative stress and anti-oxidants in pre-eclampsia. Semin. Reprod. Endicrinol. 1998;16:93-104.

Pandey S, Singh B, Agnihotari M, Mahdi AA. Comparative status if oxidant/anti-oxidant in pregnancy induced hypertension and cervical dysplasia. International journal of Research and Development in Pharmacy and Life Sciences. 2013;2:620-5.

Chamy VM, Lepe J, Catalan A, Retamal D, Escobar JA, Madrid EM. Oxidative stress is closely related to clinical severity of pre-eclampsia. Biol. Res. 2006;39:229-36.

Dave J, Vaidya M, Sharma M. A comparative study of degree of oxidative stress in pre-eclampticand healthy pregnant womwn in Madhya Pradesh. Int J Adv Pharm Bio. Chem. 2012;01:397-401.

Krishna MS, Venkataramana G. Study of lipid peroxidation, glutathione, ascorbic acid, vitamin E and anti-oxidant enzymes in patients with pregnancy induced hypertension. Indian J. Physiol. Pharmacol. 2007;51:284-8.

Suhail M, Suhail MF, Khan H. Role of vitamin C and E in regulating anti-oxidant and pro-oxidant markers in pre-eclampsia. J. Clin. Biochem. Nutr. 2008;43:210-20.

Suhail M, Suhail MF, Khan H. Alerations in anti-oxidant and pro-oxidant balance in pre-eclampsia-impact on erythrocyte osmotic fagility. Biochem. Med. 2008;3:331-41.




How to Cite

Shah, A., Rashid, A., Khan, M. S., Parvez, T., Kaisar, M., & Mudassar, S. (2019). Pregnancy induced hypertension: lipid peroxidation and antioxidant status. International Journal of Research in Medical Sciences, 7(8), 2909–2914.



Original Research Articles