Study of vitamins in pulmonary Tuberculosis

Shubhangi M. Dalvi, Vinayak W. Patil, Nagsen N. Ramraje, Neelam Yeram, Priti Meshram


Background: In recent years, progress in Tuberculosis (TB) control and eradication has been threatened by the emergence of drug resistant strains of Mycobacterium tuberculosis (MTB). Several studies describe micronutrient malnutrition in TB. This study focuses on the effect of drug resistance and disease progression on levels of various vitamins.

Methods: The case control study comprised of 50 normal healthy human volunteers (Control), 50 newly diagnosed TB patients (CAT I) and 50 TB patients showing multi drug resistance (MDR). Recruited subjects were of both genders in age group of 18- 60 years and from different socioeconomic status. Blood serum samples analysed for levels of Vitamin A, Vitamin D, Vitamin E, Vitamin C, Vitamin B12 and Folic acid by using Spectrophotometer, ELISA and Chemiluminescence instruments. Statistical evaluation was done for correlation among variables.

Results: The levels of vitamins in TB patients were significantly reduced when compared with controls. Also, MDR-TB patients showed severe malnourished state in comparison to those who were newly diagnosed for the disease.

Conclusions: There is a need to provide vitamin supplements in proper sufficient dosage with anti-TB drugs during treatment, which will help fight against the disease and ensure rapid recovery of the patients.


Folic acid, Tuberculosis, Vitamin

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World Health Organization (WHO). Global Tuberculosis Report. Geneva, Switzerland: World Health Organization. Available at: Accessed 2016.

Edem VF, Ige O, Arinola OG. Plasma vitamins and essential trace elements in multi-drug resistant tuberculosis patients before and during chemotherapy. Egypt J Chest Dis Tubercul. 2016;65(2):441-5.

Aibana O, Franke MF, Huang CC, Galea JT, Calderon R, Zhang Z, et al. Impact of vitamin A and carotenoids on the risk of tuberculosis progression. Clin Infect Dis. 2017;65(6):900-9.

Tyagi G, Singh P, Varma-Basil M, Bose M. Role of Vitamins B, C, and D in the fight against tuberculosis. International J Mycobacteriol. 2017;6(4):328.

Fajar Yulianto Karna Rajasa, Hermawan Nagar Rasyid, Bambang Tiksnadi, Ahmad Ramdan, Yoyos Dias Ismiarto, Ramco Abtiza. antituberculosis supplement in spinal tuberculosis treatment. Progress in Orthop Sci. 2018; 4(1): 1-6.

Karyadi E, West CE, Schultink W, Nelwan RH, Gross R, Amin Z, et al. A double-blind, placebo-controlled study of vitamin A and zinc supplementation in persons with tuberculosis in Indonesia: effects on clinical response and nutritional status. Am J Clin Nutrit. 2002;75(4):720-7.

Sikri K, Batra SD, Nandi M, Kumari P, Taneja NK, Tyagi JS. The pleiotropic transcriptional response of Mycobacterium tuberculosis to vitamin C is robust and overlaps with the bacterial response to multiple intracellular stresses. Microbiol. 2015;161(4):739-53.

Škodrić-Trifunović V, Blanka A, Stjepanović MI, Ignjatović S, Mihailović-Vučinić V, Šumarac Z, Buha I, Ilić K. The health benefits of vitamin D relevant for tuberculosis. J Med Biochem. 2014;33(4):301-6.

Gopinath K, Venclovas Č, Ioerger TR, Sacchettini JC, McKinney JD, Mizrahi V, et al. A vitamin B12 transporter in Mycobacterium tuberculosis. Open Biol. 2013;3(2):120175.

Chakraborty S, Syal K, Bhattacharyya R, Banerjee D. Vitamin deficiency and tuberculosis: need for urgent clinical trial for management of tuberculosis. J Nutr Health Food Sci. 2014;2(2):1-6.

Oh J, Choi R, Park HD, Lee H, Jeong BH, Park HY, et al. Evaluation of vitamin status in patients with pulmonary tuberculosis. J Infect. 2017;74(3):272-80.

Dalvi SM, Patil VW, Ramraje NN, Phadtare JM, Gujarathi SU. Nitric oxide, carbonyl protein, lipid peroxidation and correlation between antioxidant vitamins in different categories of pulmonary and extra pulmonary tuberculosis. Malays J Med Sci: MJMS. 2013;20(1):21.