Histopathological study of thyroid lesions and correlation with ultrasonography and thyroid profile in western zone of Rajasthan, India


  • Aahana Gupta Department of Paediatrics, Sardar Patel Medical College, Bikaner, Rajasthan
  • Durgashankar Jaipal Department of Pathology, Sardar Patel Medical College, Bikaner, Rajasthan
  • Sunita Kulhari Department of Pathology, Sardar Patel Medical College, Bikaner, Rajasthan
  • Neelu Gupta Department of Pathology, Sardar Patel Medical College, Bikaner, Rajasthan




Thyroid swelling, Multinodular goiter, Histopathology, Ultrasonography, Thyroid profile


Background: To evaluate the different patterns of thyroid lesions in surgically resected specimens and biopsies received at department of pathology and correlate the various histo-morphological features with respect to clinical findings, USG and thyroid profile findings.

Methods: Total 100 cases of partial or complete thyroidectomy were studied. A detailed clinical examination with USG examination and assessment of thyroid function test were carried out preoperatively.

Results: The highest incidences (51%) of thyroid enlargements were found in age group of 21-40 years with females predominated (77%), ratio being 3.34:1. Out of total 100 cases, 28 were neoplastic and 72 were non-neoplastic. Thyroid function test was carried out of all 100 cases and out of them 81 were euthyroid. Most common clinical symptom in the patients of thyroid lesions was swelling in the neck which was present in all cases. Multinodular goiter was the most common radiological finding seen in 55% cases. Out of 55 cases of MNG one case turned out to be malignant after histopathological examination. USG diagnosed 10 cases were malignant, out of them 1 case turned out to be benign after histopathological examination.

Conclusions: Taking into consideration histopathology report as a gold standard, correlation of USG finding with histopathology finding showed 90% sensitivity, 98.8% specificity with 90% positive predictive value.


Tsegaye B, Ergete W. Histopathologic pattern of thyroid disease. East Arf Med J. 2003;80:525-28.

Ananthakrishnan N, Rao KM, Narasimhans R, Veliath, Smilet SR, Jagadish S. The Single Thyroid Nodule: A South Indian Profile of 503 Patients with Special Reference to Incidence of Malignancy. Indian J Surg. 1993;55(10):487-92.

Baloch Z, Livolsi V. Pathology of thyroid and parathyroid disease. In: Sternberg’s diagnostic surgical pathology. 4th ed. Edinburgh: Lippincott Williams & Wilkins. 2004:557-95.

Bhargava S, Bansal R, Elhence P, Pandey S, Makkar N. Cyto-histological correlation of thyroid lessions with Estrogen and Progesterone receptor status on neoplastic leisons. Journal of clinical and diagnostic research. 2012;6(5):811-15.

Singh P, Chopra R, Calton N, Kapoor R. Diagnostic Accuracy of Fine Needle Aspiration Cytology of Thyroid lesions. Journal of Cytology. 2000;17(3):135-9.

Islam R, Ekramuddaula AFM, Alam MS , Kabir MS, Hossain D, Alauddin M. Frequency & pattern of malignancy in solitary thyroid nodule. Bangladesh J of Otorhinolaryngology. 2009;15(1):1-5.

Rangaswamy M, Narendra KL, Patel S, Guruprasad C, Manjunath GV. Insight to neoplastic thyroid lesions by fine needle aspiration cytology. J Cytol. 2013;30(1):23-6.

Sangalli G, Sergio G, Zampatti C, Bellotti M, Lomuscio G. Fine needle aspiration cytology of the thyroid: A comparison of 5469 cytological and final histological diagnosis. Cytopathology. 2006;17(5):245-50.

Mandal S, Barman D, Mukherjee A, Mukherjee D, Saha J, Sinha R. Fine needle aspiration cytology of thyroid nodules-evaluation of its role in diagnosis and management. J Indian Med Assoc. 2011;109(4):258-61.

Ashraf SA, Matin ASM. A Review of thyroid diseases in Bangladesh. Journal of BCPS. 1996;2(1):6-10.

Krukowski ZH. The thyroid gland and thyroglossal tract. In: Williams NS, Bulstrode CJK, O’Connell PR, eds. Baily & Love’s short practice of surgery. 24th ed. London. Hodder education. 2004:776-804.

Rains AJH, Charles VM. In: Russel RCG, Williams NS, Bulstrode CJK, Bulstrode C, O’Connell PR, eds. Bailey and Love’s short practice of surgery, 23rd ed. London, ELBS. 2000:707-33.

Psarras A, Papadopoulos SN, Livadas D, Pharmakiotis AD, Koutras DA. The single thyroid nodule. Br J Surg. 1972;59(7):545-8.

Prakash A, Moulik BK, Sharma LK, Kapur M, Poddar PK. Carcinoma of thyroid gland. A clinical study. Ind J Surg. 1974;43:409-16.

Godinho-Matos L, Kocjan G, Kurtz A. Contribution of fine needle aspiration cytology to diagnosis and management of thyroid disease. J Clin Pathol. 1992;45:391-5.

Stark DD, Clark OH, Gooding GAW, Moss AA. High-resolution ultrasonography and computed tomography of thyroid lesions in patients with hyperparathyroidism. Surgery. 1983;94:863.

Messaris G, Kyriakov K, Vasilopoulos P, Tountas C. The single thyroid nodule and carcinoma.Br J Surg. 1974;61:943.

Gupta M, Gupta S, Gupta VB. Correlation of Fine Needle Aspiration Cytology with Histopathology in the Diagnosis of Solitary Thyroid Nodule. Journal of Thyroid Research. 2010:379051.

Jones AJ, Aitman TJ, Edmonds CJ, Burke M, Hudson E, Tellez M. Comparison of fine needle aspiration cytology, radioisotopic and ultrasound scanning in the management of thyroid nodules. Postgrad Med J. 1990;66(781):914-7.

Watters DA, Ahuja AT, Evans RM, Chick W, King WW, Metreweli C. Role of USG in the management of thyroid nodule.Am J Surg. 1998;164(6):654-7.

Cai XJ, Valiyaparambath N, Nixon P, Waghorn A, Giles T, Helliwell T. Ultrasound-guided fine needle aspiration cytology in the diagnosis and management of thyroid nodules. Cytopathology. 2006;17(5):251-6.

Warpe BM. Cyto-diagnosis of thyroid lesions. 2013. Available at http://www.ijser.org/thesis/publication/TH_PUQZX6.pdf. Accessed 10 February 2016.

Dohney CC. Clear answers for common questions of thyroid nodule, 2012. Available from http://www.wiseGEEK Thyroid nodule.com. Accessed 10 August. 2012.




How to Cite

Gupta, A., Jaipal, D., Kulhari, S., & Gupta, N. (2016). Histopathological study of thyroid lesions and correlation with ultrasonography and thyroid profile in western zone of Rajasthan, India. International Journal of Research in Medical Sciences, 4(4), 1204–1208. https://doi.org/10.18203/2320-6012.ijrms20160810



Original Research Articles