Association of C- reactive protein level and lipid profile in periodontitis and ischemic heart disease in urban population of Malwa region

Priya Joshi, Himanshu Dagor


Background: Various studies have explored the relationship between periodontal disease and ischemic heart disease but their result is diverse. This review article is designed to update the relationship among periodontal disease and ischemic heart disease. Hence, the aim of the present study was to assess whether there is a link between periodontal and ischemic heart disease (IHD).

Methods: This study includes 90 subjects, which were divided into 3 groups: 30 subjects -healthy individuals, 30 subjects- having Periodontitis, 30 subjects- suffering from ischemic heart diseases.

Results: The mean OHI-S scores for group 1, 2 and 3 were 0.95±0.60, 2.91±0.90, 1.54±0.74 respectively. CRP level group 2 and 3 were significantly higher than group 1 (p=0.002 and 0.00 respectively) whereas difference between group 2 and 3 was not significantly significant. Lipid profiles, cholesterol, low density lipoprotein (LDL), triglycerides higher in group 2 as compare to 1 and 3. High density lipoprotein (HDL) levels between groups were not significantly different.

Conclusions: Based on findings and other reports Periodontitis could be a predisposing factor for IHD and perhaps there can be an association among both the diseases.


C-reactive protein, Ischemic heart disease, Lipid metabolism, Periodontitis

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Bullon P, Newman HN, Battino M. Obesity, diabetes mellitus, atherosclerosis and chronic periodontitis: a shared pathology via oxidative stress and mitochondrial dysfunction? Periodontol. 2014;64(1):139-53.

Luis-Delgado O ,Echevarría-García JJ ,Berini-Aytés L , Gay-Escoda Periodontitis as a risk factor in patients with ischemic heart disease.Europe PMC01 Mar 2004;9(2):131-7, 125-31.

London GM. The clinical epidemiology of cardiovascular diseases in chronic kidney disease: cardiovascular disease in chronic renal failure: pathophysiologic aspects. Seminars Dialysis. 2003;16(2):85-94.

Anjanaa R, Suresha R. Periodontal infection, a risk for ischemic heart disease. SRJM. 2010;3:12-9.

Mattila KJ, Nieminen MS, Valtonen VV, Rasi VP, Kesäniemi YA, Syrjälä SL, et al. Association between dental health and acute myocardial infarction BMJ 1989 Mar 25;298(6676):779-81.

Islam A, Rahman M, Ullah M, Yeasmin L. Link between periodontal disease and coronary artery disease. Bangladesh Perspective. 2014;7(10):44-54.

Sharma A, Astekar M, Metgud R, Soni A, Verma M, Patel S. A study of C-reactive protein, lipid metabolism and peripheral blood to identify a link between periodontitis and cardiovascular disease. Biotechnic Histochemistr. 2014;89(9):577-82.

Thompson GR, Soutar AK, Spengel FA, Jadhav A, Gavigan SJ, Myant NB. Defects of receptor- mediated low-density lipoprotein catabolism in homozygous familial hypercholesterolemia and hypothyroidism in vivo. Proceedings National Academy Sci. 1981;78(4):2591-5.

Rizos CV, Elisaf MS, Liberopoulos EN. Effects of thyroid dysfunction on lipid profile. Open Cardiovascular Med J. 2011;5:76.