MicroRNAs in colorectal cancer


  • Jonathan E. Cruz-Escobar Physician, Faculty of Medicine, UNAM, CDMX, Mexico
  • Alan Isaac Valderrama-Treviño Laboratory of Experimental Immunotherapy and Tissue Engineering, Faculty of Medicine, UNAM, CDMX, Mexico
  • Jesús C. Ceballos-Villalva Physician, Faculty of Medicine, UNAM, CDMX, Mexico
  • Mariana Ramírez-Guerrero Physician, Faculty of Medicine. UNAM. CDMX. Mexico
  • German E. Mendoza-Barrera Department of General Surgery, Creighton University Medical Center, Omaha, Nebraska, USA.
  • Ericka H. Contreras-Flores Physician, Faculty of Medicine. UNAM. CDMX. Mexico.
  • Luis R. Carazo-Quiroz Department of Plastic and Reconstructive Surgery. CMNSXXI, IMSS. CDMX. Mexico.
  • Rodrigo Banegas-Ruiz Department of Traumatology. Rehabilitation Hospital, Luis Guillermo Ibarra Ibarra. CDMX. Mexico.
  • Baltazar Barrera-Mera Department of Physiology. Faculty of Medicine. UNAM. CDMX. Mexico.




Biomarkers, Colorectal cancer, Diagnosis, MicroRNAs, Prognosis, Survival


Colorectal cancer (CRC) is the third most common type of cancer worldwide, currently representing the most common gastrointestinal cancer with 13% of all malignant tumors. MicroRNAs (miRNAs) are small non-coding RNAs that repress the translation of target genes. Since their discovery, they have been shown to play an important role in the development of cancer, since they can act as tumor suppressors or oncogenes. A literature review was performed in different databases such as Medline, PubMed, Cochrane, nature, Wolters Kluwer, ScienceDirect, Scopus, SpringerLink, Wiley Online Library. Studies were included from 2003 to 2018. Colorectal cancer presents genetic heterogeneity, because it can develop in different ways, the pathway through which cancer occurs depends on the gene initially altered. The aberrant expression of microRNAs is implicated in the development of colorectal cancer and its progression. Three existing steps in the maturation of the microRNAs have been identified: 1) transcription of the pri-miRNA, 2) cleavage in the nucleus to form the pre-miRNA and 3) a final excision in the cytoplasm to form the mature microRNA. It has been discovered that miRNAs have an impact on cell proliferation, apoptosis, stress response, maintenance of stem cell potency and metabolism, all important factors in the etiology of cancer. The data analyzed in this article highlights the importance of the study of microRNAs in colorectal cancer, however, for the carcinogenic process, progression, therapeutic management and prognosis, more multicenter randomized clinical trials are needed with a detailed analysis.


Smith RET, Renaud RC, Hoffman E. Colorectal cáncer market. Nat Rev Drug Discov. 2004; 3:471–472.

Dobre M, Dinu DE, Panaitescu E, Birla RD, Iosif CI, Boeriu M, et al. Kras gene mutations–prognostic factor in colorectal cancer. Rom J Morphol Embryol. 2015;56 (2 Suppl):671-8.

Amankwatia EB, Chakravarty P, Carey FA, Weidlich S, Steele RJ, Munro AJ, et al. MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and-independent mechanisms. British J cancer. 2015;112(9):1480.

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA: a cancer J clinicians. 2015;65(1):5-29.

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA: a cancer J clinicians. 2016;66(1):7-30.

Manne U, Shanmugam C, Katkouri VR, Bumpers HL, Grizzie WE. Development and progression of colorectal neoplasia. Cancer Biomark. 2010;9(1-6):235-65

Jenkinson F, Steele RJ. Colorectal cancer screening-methodology. Surgeon. 2010;8:164-71.

Juárez Vázquez CI, Rosales Reynoso MA. Colorectal cancer (CRC): genetic and molecular alterations. Medical Gazette of Mexico. 2014; 150 (2): 154-64.

Russo A, Rizzo S, Bronte G, Silvestris N, Colucci G, Gebbia N, et al. The long and winding road to useful predictive factors for anti-EGFR therapy in metastatic colorectal carcinoma: the KRAS/BRAF pathway. Oncol. 2009;77 (Suppl. 1):57-68.

Rúa KA, Peña CM. Molecular basis of colorectal cancer. Iatreia 2012;25(2):137-48.

Pritchard CC, Grady WM. Colorectal cancer molecular biology moves into clinical practice. Gut. 2011;60(1):116-29.

Clara Ibet Juárez-Vázquez, Mónica Alejandra Rosales-Reynoso. Colorectal cancer (CRC): genetic and molecular alterations. Medical Gazette of Mexico. 2014;150:154-64.

Lin S, Gregory RI. MicroRNA biogenesis pathways in cancer. Nat Rev Cancer. 2015;15(6):321.

Romero-Cordoba SL, Salido-Guadarrama I, Rodriguez-Dorantes M, Hidalgo-Miranda A. miRNA biogenesis: biological impact in the development of cancer. Cancer Biol Therapy. 2014;15(11):1444-55.

Gopalan V, Pillai S, Ebrahimi F, Salajegheh A, Lam TC, Le TK, et al. Regulation of microRNA‐1288 in colorectal cancer: Altered expression and its clinicopathological significance. Molecular Carcinogenesis. 2014;53(S1):E36-44.

Ambros V. The functions of animal microRNAs. Nature. 2004;431(7006):350.

Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116(2):281-97.

Iorio MV, Croce CM. MicroRNAs in cancer: small molecules with a huge impact. J Clinic Oncol. 2009;27(34):5848.

Michael MZ, O'Connor SM, van Holst Pellekaan NG, Young GP, James RJ. Reduced Accumulation of Specific MicroRNAs in Colorectal Neoplasia11Note: Susan M. O'Connor and Nicholas G. van Holst Pellekaan contributed equally to this work. Molecular Cancer Res. 2003;1(12):882-91.

Park SY, Kim H, Yoon S, Bae JA, Choi SY, Do Jung Y, et al. KITENIN-targeting microRNA-124 suppresses colorectal cancer cell motility and tumorigenesis. Molecular Ther. 2014;22(9):1653-64.

Slattery ML, Herrick JS, Mullany LE, Wolff E, Hoffman MD, Pellatt DF, et al. Colorectal tumor molecular phenotype and miRNA: expression profiles and prognosis. Modern Pathol. 2017;29(8):915.

Schetter AJ, Okayama H, Harris CC. The role of microRNAs in colorectal cancer. Cancer J (Sudbury, Mass.). 2012;18(3):244.

Wu CW, Ng SC, Dong Y, Tian L, Ng SS, Leung WW, et al. Identification of microRNA-135b in stool as a potential noninvasive biomarker for colorectal cancer and adenoma. Clin Cancer Res. 2014;20(11):2994-3002.

Bartley AN, Yao H, Barkoh BA, Ivan C, Mishra BM, Rashid A, et al. Complex patterns of altered MicroRNA expression during the adenoma-adenocarcinoma sequence for microsatellite-stable colorectal cancer. Clin Cancer Res. 2011;17(23):7283-93.

Huang L, Dai T, Lin X, Zhao X, Chen X, Wang C, et al. MicroRNA-224 targets RKIP to control cell invasion and expression of metastasis genes in human breast cancer cells. Biochemical Biophysical Res Communications. 2012;425(2):127-33.

Ferracin M, Veronese A, Negrini M. Micromarkers: miRNAs in cancer diagnosis and prognosis. Expert review of molecular diagnostics. 2010;10(3):297-308.

Nugent M, Miller N, Kerin MJ. MicroRNAs in colorectal cancer: function, dysregulation and potential as novel biomarkers. Euro J Surg Oncol (EJSO). 2011;37(8):649-54.

Menéndez-Sánchez P, Villarejo-Campos P, Padilla-Valverde D, Menéndez-Rubio JM, Rodríguez-Montes JA. Tumor markers in colorectal cancer. Surgery and Surgeons. 2013; 81 (2): 169-75.

Hollis M, Nair K, Vyas A, Chaturvedi LS, Gambhir S, Vyas D. MicroRNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity. World J Gastroenterol. 2015;21(27):8284.

Kosaka N, Iguchi H, Ochiya T. Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis. Cancer sci. 2010;101(10):2087-92.




How to Cite

Cruz-Escobar, J. E., Valderrama-Treviño, A. I., Ceballos-Villalva, J. C., Ramírez-Guerrero, M., Mendoza-Barrera, G. E., Contreras-Flores, E. H., Carazo-Quiroz, L. R., Banegas-Ruiz, R., & Barrera-Mera, B. (2019). MicroRNAs in colorectal cancer. International Journal of Research in Medical Sciences, 7(8), 3206–3209. https://doi.org/10.18203/2320-6012.ijrms20193146



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