DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20160821

Clinicopathological representation of nonmetastatic Ewing sarcoma of the scapula - a case study

Vinod Kumar A., Ramesh Shankar, Kaviraj Mahadevan, Susheela M.

Abstract


Ewing sarcoma (ES) is a rare type of small cell tumor of the bone and soft tissues. About 50% of ES arise in the femur and pelvis. We present a case of ES of the scapula in a seven year old female child. Because of its similarity with other small cell tumors, the diagnosis of ES is challenging and requires a combination of methods like CT scan, MRI report, histopathological evaluation and IHC, etc. The MRI report of our case has shown a consistent 5×4 cm3 mass on the left scapula. Bone marrow aspiration and biopsy of the tumor has been further analyzed. Small, round and oval cells with densely packed nuclei and scanty cytoplasm, which are characteristic to ES were observed microscopically. A positive reaction to vimentin and CD99 and negative result for the biomarkers meant for other types of tumors, favours the diagnosis of ES. The chromosomes analyzed from the peripheral blood of the patient have shown a normal karyotype. Early diagnosis of ES is very crucial for treatment. Histopathology and IHC are indispensible tools in the diagnosis of ES.


Keywords


ES, Histopathology, IHC, CD99, Karyotype

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References


Gervalmld L, Enzingemrd FM. Extraskeletal Neoplasm resembling ewing's sarcoma. Cancer. 1975;36:240-51.

Gopalakrishnan CV, Shrivastava A, Easwer HV, Nair S. Primary Ewing's sarcoma of the spine presenting as acute paraplegia. J Pediatr Neurosci. 2012;7(1):64-6.

Iwamoto Y. Diagnosis and Treatment of Ewing’s Sarcoma. Jpn J Clin Oncol. 2007;37(2):79-89.

Worch J, Matthay KK, Neuhaus J, Goldsby R, DuBois SG. Ethnic and racial differences in patients with Ewing sarcoma. Cancer. 2010;116(4):983-8.

Hattinger CM, Potschger U, Tarkkanen M, Squire J, Zielenska M, Kiuru-Kuhlefelt S, et al. Prognostic impact of chromosomal aberrations in Ewing tumours. British Journal of Cancer. 2002;86:1763-9.

Brazao-Silva MT, Fernandes AV, de Faria PR, Cardoso SV, Loyola AM. Ewing’s Sarcoma of the Mandible in a Young Child. Braz Dent J. 2010;21(1):74-9.

Chakrabarti N, Dewasi N, Das S, Bandyopadhyay A, Bhaduri N. Primary Ewing’s Sarcoma/Primitive Neuroectodermal Tumor of Kidney - a Diagnostic Dilemma. Iran J Cancer Prev. 2015;2:129-33.

Bazzocchi A, Bacci A, Serchi E, Salerno A, Salizzoni E, Leonardi M. Intradural extramedullary Ewing’s sarcoma recurrence with acute clinical presentation and literature review. The Neuroradiology Journal. 2013;26:476-81.

Krishnamani K, Kumar TN, Gandhi LV, Raghunadharao D, Sadashivudu G, Megha U. Primary Ewing’s sarcoma of the cranium: Case series and review of literature. Journal of Cancer Research and Therapeutics. 2014;10(2):377-80.

Yip C, Hsu S, Chang N, Wang J, Liao W, Chen J, et al. Primary vaginal extraosseous Ewing sarcoma/primitive neuroectodermal tumor with cranial metastasis. J Chin Med Assoc. 2009;72(6):332-5.

Casorzo L, Fessia L, Sapino A, Ponzio G, Bussolati G. Extraskeletal Ewing's tumor with translocation t (11;22) in a patient with down syndrome. Cancer Genet Cytogenet. 1989;37:79-84.