Rhabdomyolysis and acute kidney injury in the deceased donor: a case report

Authors

  • Donghua Zheng Department of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
  • Hua Liu Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
  • Yaping Zhan Department of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
  • Guixing Xu Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

DOI:

https://doi.org/10.18203/2320-6012.ijrms20195023

Keywords:

Acute kidney injury, Donor, Rhabdomyolysis, Transplantation

Abstract

Rhabdomyolysis is a common complication among brain death donors, affecting the number of organ donations and the quality of donor kidneys. Case report: Male, 17 years old, admitted to the hospital due to a car accident. Subsequently, brown urine appeared, blood myoglobin increased significantly, urine output decreased, and renal function impaired. Treatments including fluid replacement, alkalization of urine, plasma exchange and bedside CRRT were given. The patient's renal function recovered, and the organs were successfully acquired. The renal function recovered well after transplantation. Conclusion: Attention should be paid to rhabdomyolysis. Early diagnosis and treatment of patients with brain death could improve donation success rate and the recovery of postoperative renal function.

References

Nimmo GR, Lambie AT, Cumming AD. Rhabdomyolysis and acute renal failure. Inten Car Med.1989;15(8):486-7.

Vanholder R, Sever MS, Erek E. Rhabdomyolysis. J Am Soc Nephrol. 2000;11(8):1553-61.

Mekeel KL, Moss AA, Mulligan DC. Deceased donor kidney transplantation from donors with acute renal failure due to rhabdomyolysis. Am J Trans. 2009;9(7):1666-70.

Better OS, Abassi ZA. Early fluid resuscitation in patients with rhabdomyolysis. Nat Rev Nephrol. 2011;7(7):416-22.

Brain Injury Evaluation Quality Control Centre of National H, Family Planning C. Criteria and practical guidance for determination of brain death in adults (BQCC version). Chin Med J (Engl) 2013;126:4786-90.

Petejova N, Martinek A. Acute kidney injury due to rhabdomyolysis and renal replacement therapy: a critical review. Crit Care. 2014;18(3):224.

Cervellin G, Comelli I, Benatti M. Non-traumatic rhabdomyolysis: Background, laboratory features, and acute clinical management. Clin Biochem. 2017;50(12):656-62.

Chen X, Huang G, Yang S. Successful Transplantation of Black Kidneys Due to Myoglobin Nephropathy. Transplant Proc. 2018;50(8):2436-8.

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Published

2019-10-24

How to Cite

Zheng, D., Liu, H., Zhan, Y., & Xu, G. (2019). Rhabdomyolysis and acute kidney injury in the deceased donor: a case report. International Journal of Research in Medical Sciences, 7(11), 4388–4391. https://doi.org/10.18203/2320-6012.ijrms20195023

Issue

Section

Case Reports