DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20195528

Clinicopathological spectrum of peripheral lung tumors in resected lung specimens: a single institutional study in a tertiary care centre

Duri Mateen, Naheena Bashir, Ajaz Muzamil, Naseema Chanda

Abstract


Background: Lung cancer is the most common cancer and by far the leading cause of cancer death among both men and women in the world. In Kashmir, in the recent study, Lung carcinoma was found to be second common in males and sixth in females in Kashmir. This study was carried out to study the demography, clinical presentation, risk factors and histopathological pattern of peripheral lung tumours in resected specimens and to evaluate the added advantage of Immunohistochemistry for enhancing the diagnostic accuracy.

Methods: It was a five-year study conducted in the Department of Pathology, SKIMS and the cases from June 2009 to April 2012 were analysed retrospectively while the cases from June 2012 to May 2014 were evaluated prospectively. A total of 97 cases with peripheral lung tumor in whom resection was done were studied.

Results: Majority of the cases were seen in males (84.53%) in the fifth decade of life. Cough was the most common symptom, present in 58.76% patients. Right lung was involved in majority of the cases, 57.95% and left lung was involved in 42.04 %. Maximum growth size as seen on gross examination was 8 cm and minimum were 1 cms. Most common histopathological subtype was squamous cell carcinoma seen in 64.94% followed by adenocarcinoma seen in 19.58% of the patients. Lymph nodes were involved in 41 cases (52.56%) and were free in 37 patients (47.43%). IHC was done wherever required and was consistent with histopathology.

Conclusions: To improve the therapeutic results of lung cancers efforts for early detection and treatment are essential. Timely intervention with the help of surgery, histopathology and immunohistochemistry are hence very helpful.


Keywords


Lung, Pathology, Smoking, Tumors

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References


Cruz CS, Tanoue LT, Matthay RA. Lung cancer: epidemiology, etiology, and prevention. Clini Chest Med. 2011 Dec 1;32(4):605-44.

Nath V, Grewal KS. Cancer in India. Ind J Med Res 1935;23:149-90.

Wani MA, Jan FA, Khan NA, Pandita KK, Khurshid R, Khan SH. Cancer trends in Kashmir; common types, site incidence and demographic profiles: National Cancer Registry 2000-2012. Indian J Cancer. 2014 Apr 1;51(2):133-7.

Verma S, Slutsky AS. Idiopathic pulmonary fibrosis-new insights. N Engl J Med. 2007;356:1370-2.

Tan D, Zander DS. Immunohistochemistry for assessment of pulmonary and pleural neoplasms: a review and update. Int J Clin Exp Pathol. 2002;15:1058-67.

Jubelirer SJ, Wilson RA. Lung cancer in patients younger than 40 years of age. Cancer. 1991 Mar 1;67(5):1436-8.

Collins LG, Haines C, Perkel R, Enck RE. Lung cancer diagnosis and management. Am Fam Physician. 2007; Jan 1;75(1):56-63.

Hussain AN. The Lung. Robbins and Cotran. Pathological Basis of Disease. Saunders Elsevier. 2010;8:721.

Samet JM, Avila-Tang E, Boffetta P, Hannan LM, Olivo-Marston S, Thun MJ, et al. Lung cancer in never smokers: clinical epidemiology and environmental risk factors. Clini Cancer Resea. 2009 Sep 15;15(18):5626-45.

Kato H, Nakamura H, Tsuboi M, Ikeda N, Tsuchida T, Kato Y, et al. Treatment of peripheral early stage lung cancer. Annals thoracic cardio surg. 2004 Jan 1;10(1):1-3.

Stojsić J, Adzić T, Marić D, Subotić D, Milovanović I, Milenković B, et al. Histological types and age distribution of lung cancer operated patients over a 20-year period: a pathohistological based study. Srp Arh Celok Lek. 2011 Sep;139(9-10):619-24.

Bhurgri Y, Bhurgri A, Usman A, Sheikh N, Faridi N, Malik J, et al. Patho-epidemiology of lung cancer in Karachi (1995-2002). Asian Pacific J Cancer Prev. 2006 Jan 25;7(1):60-4.

Sundaram V, Sanyal N. Clinicopathological profile of bronchogenic carcinoma in a tertiary care hospital in eastern part of India. Clini Cancer Investigation J. 2014;3(3):220-4.

Valaitis J, Warren S, Gamble D. Increasing incidence of adenocarcinoma of the lung.Cancer.1981;47:1042-1046.

Nafae A, Misra SP, Dhar SN, Shah SN. Bronchogenic carcinoma in Kashmir Valley. The Indian J Chest Dis. 1973 Oct;15(4):285-95.

Khan NA, Afroz F, Lone MM, Teli MA, Muzaffar M, Jan N. Profile of lung cancer in Kashmir, India: a five-year study. Small. 2006 Jul;55:17.

El Aziz SF, Mourad I, Sedera MA. NSCLC: Evaluation of a two-year experience of surgical treatment for lung cancer in the national cancer institute. J Egyptian Nati Cancer Inst. 2001;13(2);117-128.

Shiner RJ, Rosenman J, Katz I, Reichart N, Hershko E, Yellin A. Bronchoscopic evaluation of peripheral lung tumours. Thorax. 1988 Nov 1;43(11):887-9.

Oscar Auerbach MD, Lawrence Garfinkel MA. The changing pattern of lung carcinoma. Cancer. 1991,68:1973-77.

Treasure T, Belcher JR. Prognosis of peripheral lung tumours related to size of the primary. Thorax. 1981 Jan 1;36(1):5-8.

Zhang D, Zhang R, Cheng G. The surgical treatment of lung cancer: a retrospective analysis of 2004 cases. Chin Med J. 1999 Jan;112(1):25-8.

Behara D, Balamujesh T. Lung cancer in India. Indian J Chest Dis Allied Sci. 2004;46:269-81.

Wahbah M, Boroumand N, Castro C, El-Zeky F, Eltorky M. Changing trends in the distribution of the histologic types of lung cancer: a review of 4,439 cases. Annals Diagnostic Pathol. 2007 Apr 1;11(2):89-96.

Santos-Martínez MJ, Curull V, Blanco ML, Macià F, Mojal S, Vila J, et al. Lung cancer at a university hospital: epidemiological and histological characteristics of a recent and a historical series. Archivos Bronconeumol. 2005 Jun 1;41(6):307-12.

Stockwell HG, Armstrong AW, Leaverton PE. Histopathology of lung canver among smokers and non-smokers in Florida. Int J epidemiol.1990;19:48-52.

Rapiti E, Jindal SK, Gupta D, Boffetta P. Passive smoking and lung cancer in Chandigarh, India. Lung Cancer. 1999 Mar 1;23(3):183-9.