Prevalence of primary drug resistance to rifampicin and isoniazid in newly diagnosed sputum smear positive pulmonary Tuberculosis

Authors

  • Ashok Kumar Department of Microbiology, Government Medical College, Patiala, Punjab, India
  • Jawahar Lal Joshi Department of Chest and TB, Government Medical College, Patiala, Punjab, India
  • Abdurazack Umathoor Department of Chest and TB, Government Medical College, Patiala, Punjab, India
  • Vishal Chopra Department of Chest and TB, Government Medical College, Patiala, Punjab, India
  • Komaldeep Kaur Department of Chest and TB, Government Medical College, Patiala, Punjab, India
  • Vidhu Mittal Department of Chest and TB, Government Medical College, Patiala, Punjab, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20193942

Keywords:

Multi-drug-resistant tuberculosis, Prevalence, Resistance

Abstract

Background: To determine the prevalence of primary drug resistance to either rifampicin or isoniazid alone or both in newly diagnosed sputum smear positive pulmonary tuberculosis patients.

Method: A prospective study 100 newly diagnosed sputum smear positive pulmonary TB patients was conducted. The patients with an age of ≥15 years and who had either not taken anti TB treatment or who had taken ATT for less than 1 month were enrolled in this study. Two sputum samples (5ml each), including one early morning sample as per the RNTCP guidelines were collected and subjected to line probe assay (LPA).

Results: Out of 100 cases 6 were having resistance to both rifampicin and isoniazid, 9 has resistance to INH alone and 1 had resistance to rifampicin alone.

Conclusion: The prevalence of primary drug resistance is high. For early and rapid detection of DR-TB newer modality should be used  for the detection of primary drug resistance in sputum smear positive TB patients.

References

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Published

2019-08-27

How to Cite

Kumar, A., Joshi, J. L., Umathoor, A., Chopra, V., Kaur, K., & Mittal, V. (2019). Prevalence of primary drug resistance to rifampicin and isoniazid in newly diagnosed sputum smear positive pulmonary Tuberculosis. International Journal of Research in Medical Sciences, 7(9), 3532–3535. https://doi.org/10.18203/2320-6012.ijrms20193942

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Original Research Articles