DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20161003

The role of aging, body mass index and estrogen on symptomatic lumbar osteoarthritis in post-menopausal women

I Ketut Suyasa, I G. N. Yudhi Setiawan

Abstract


Background: Low back pain is a common complaint which is always found in old age due to degeneration process. Degeneration process of spine, especially in the lumbar region is called lumbar osteoarthritis (OA). Various factors are thought to be the cause of lumbar OA, including primarily due to hormonal changes of estrogen and increase of age and body mass index in postmenopausal women.

Methods: The purpose of this study is to determine the role of hormonal changes pathogenesis in lumbar osteoarthritis in postmenopausal women and its correlation with age and body mass index. Cross sectional analytic method had been conducted to determine the role of age, body mass index and estrogen for lumbar OA in postmenopausal women. The study was conducted in Sanglah General Hospital from October 2015 until March 2016 by anthropometric measures and blood samples.

Results: From 196 samples showed that the estrogen deficiency in postmenopausal women have a correlation with the symptomatic lumbar OA (r=0.252, p = 0.000). While age and the body mass index in postmenopausal women has a correlation with symptomatic lumbar OA (r = 0.150 and 0.198, p = 0.000 and 0.013).

Conclusions: The aging process, body mass index and estrogen deficiency correlated with the symptomatic OA lumbar in post-menopausal women.


Keywords


Symptomatic lumbar OA, Estrogen, Age, Body mass index

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References


Wluka AE, Cicuttini FM. Spector T.D. Menopause, oestrogen and arthritis. Maturitas. 2000;30:183-99.

Chandler CL, Desa FM. The effects of estrogens on cartilage degradation using in vivo and in vitro models. Agents Actions. 1991;34(1/2):282-6.

Felson DT, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum. 1998;41:1343-55.

Rosner IA, Goldberg VM, Getzy L, Moskowitz RW. Effects of estrogen on cartilage and experimentally induced osteoarthritis. Arthritis Rheum. 1979;22(1):52-60.

Bullough P. Spinal arthritis and degenerative disc disease in Orthopaedic Pathology. 4th ed. Mosby. 2004;311-5.

Dugan TR, Kang JD. The role of inflammation in disc degeneration. In: Sharan A.D., Tang S.Y., Vaccaro A.R., editors. Basic Science of Spinal Diseases. 1st ed. India: Jaypee Brothers Medical Publisher. 2013:85-94.

Fujiwara A. The Effect of Disc Degeneration and Facet Joint Osteoarthritis on the Segmental Flexibility of the Lumbar Spine. Spine. 2000;25:3036-44.

Slikker III W. Howard S. An. Pathophysiology of Disc Degeneration. In: Sharan A.D., Tang S.Y., Vaccaro A.R., editors. Basic Science of Spinal Diseases. 1st ed. India: Jaypee Brothers Medical Publisher. 2013:73-79.

Tsai CL, Liu TK. Osteoarthritis in women. Its relationship to estrogen and current trends. Life Sci. 1992;50:1737-44.

Valdes AM. Molecular pathogenesis and genetics of

osteoarthritis: implications for personalized medicine. Personalized Medicine. 2010;7:49-63.

Richette P, Corvol M, Bardin T. Estrogen, cartilage, and osteoarthritis. Joint Bone spine. 2003;70;257-62.

Ushiyama T, Ueyama H, Inoue K, Ohkubo J, Hukuda S. Expression of genes for estrogen receptors α and β in human articular chondrocytes. Osteoarthritis cartilage. 1999;7:560-6.

Felson DT, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum. 1998;41:1343-55.

Junger S, Ritter B, Lezuo P, Alini M, Ferguson SJ, Ito K. Effect of limited nutrition on in situ intervertebral disc cells nder simulated-physiological loading. Spine. 2009;34(12):1264-71.

Sniekers YH, Weinans H, van Osch G. JVM. van Leeuwen J. PTM. Oestrogen is important for maintenance of cartilage and subchondral bone in a murine model of knee osteoarthritis. Arthritis Research & Therapy. 2010; [cited 2010 January 19]. Available from: URL: http://arthritis-research.com/ content/12/5/R182

Wong DA, Transfeldt E. Macnab’s Backache. Fourth Edition. Philadelphia: Lippincot Williams & Wilkins. 2007:166-224.

Goode AP, Carey TS, Jordan JM. Low back pain and lumbar spine osteoarthritis: how are they related? Curr Rheumatol Rep. 2013;15:305.