Evaluation of angiogenesis as a prognostic marker in prostatic neoplasm especially carcinoma of prostate

Surya Prakash, Chhaya Rani shevra, Dwijendra Nath


Background: Prostatic carcinoma shows an unusually wide range of biological potential with well-known disparity between incidence and mortality for disease. Clinico-pathological studies suggests that angiogenesis and tumor neovascularity contributes to pathogenesis of prostate cancer. The aim of this study to present study was done to assess the validity of angiogenesis as a suitable prognostic marker in various prostatic disease specially the neoplasm’s including the malignant ones. Settings and design are Retrospective study.

Methods: The present study of evaluation of angiogenesis as a prognostic marker in prostatic neoplasm especially carcinoma of prostate was done with 40 biopsy sample. The biopsy sample were obtained by suprapubic prostatectomy specimen and trans rectal needle biopsy specimen. Tissue sections were subjected to routine H and E staining. For demonstration of angiogenesis staining for reticulin fibers was applied.

Results: The microvessels density  increases as the severity of lesion increases from benign to pre-neoplastic to frankly malignant. The micro vessel density in malignant lesions is approximately thrice that in benign lesions. Conclusions: Very few studies have been done in prostatic lesions Hence an attempt is made to demonstrate and correlate angiogenesis as a tumour marker.


Angiogenesis, Benign prostatic hyperplasia, Micro vessal density, Prostatic carcinoma

Full Text:



Gleason DF, Mellinger GT. Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. J Urol. 1974;111(1):58-64.

Pedersen KV, Herder A. Radical retro pubic prostatectomy for localized prostatic carcinoma: A clinical and pathological study of 201 cases. Scad J Urol Nephrol. 1993;27(2):219-24.

Weidner N, Folkman J, Pozza F, Bevilacqua P, Allred EN, Moore DH Tumor Angiogenesis: A new significant independent indicator in early stage breast carcinoma. INC. 1992;84(24):1875-87.

Folkman Jr. What is the evidence that tumors are angiogenesis dependent?. J Natl Cancer Instit. 1990;82(1):4-6.

Srivastava A, Laidler P, Davies RP, Horgan K, Hughes LE. The prognostic significance of tumor vascularity in intermeditate thickness skin melanoma. Am J Pathol. 1988;133(2):419-23.

Hollingsworth HC, Kohn EC, Steinberg SM, Rothenberg ML, Merino MJ. Tumor Angiogenesis in advanced stage ovarian carcinoma. Am J Pathol. 1995;147(1):33-41.

Olivarez D, Ulbright T, DeRiese W, Foster R, Reister T, Einhorn al. Neovascularisation in clinical stage A Testicular germ cell tumor: Prediction of metastatic disease. Cancer Res. 1994;54:2800-2.

Bigler SA, Deering RE, Brawer MK. Quantitative mormphometric analysis of the microcirculation in prostate carcinoma. J Cell Biochem. 1992;16H:62-4.

Berry SJ, Coffey DS, Walsh PC, Ewing LL. The development of human benign prostatic hyperplasia with age. J Urol. 1984:132:474-9

Bigler SA, Deering RE, Brawer MK: Comparision of microvascular vascularity in benign and malignant prostatic tissue. Hum Pathol. 1993;24:220-26.

Brawer MK, Bigler SA, Deering RE. Quantitative morphometric analysis of the microcirculation in Prostate carcinoma. J Cell Biochem. 1992;16:62-4.

Deering RE, Brawer MK, Browne M, Pittston SD, Bigler SA. Predictors pathologic stage in prosate carcinoma. The role of neovascularity. Cancer. 1994;73(3):678-87.