DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20194583

Role of serum copper and lipid profile in cardiovascular diseases patients of Southern Rajasthan

Parul Dhanak, Neha Sharma, Ashish Sharma

Abstract


Background: It is clear that deficiencies of some trace elements cause marked alterations in lipid and lipoprotein metabolism. The mechanisms of their effects are not completely obvious and inspite of intense research, the role of these microelements need further elucidation. Thus, the objective of this study is to evaluate the correlations of serum concentrations of trace elements including copper with lipid profile parameters of adult men in Southern Rajasthan.

Methods: Present study was conducted in Cardiology and Biochemistry Department in GMCH, Udaipur during the year 2019. A total of 150 MI cases/controls were selected. Blood sample was collected by vein puncture using an aseptic technique. The blood was allowed to settle at 37ºC and then centrifuged at 3000 rpm for 15 min. Serum was then separated and stored at -20ºC until analysis.

Results: The study cases had significantly higher lipid values than those of controls (p<0.001). In cases the copper levels are higher than the controls. Copper levels were more in males 95.40±18.93 than in females 86.93±14.54 (p<0.05). Lipid levels were higher in urban population related to rural, TC (238.47 V/s 266.59), TG (219.83 V/s 202.40), HDL (64.39 V/s 54.19) and LDL (131.28 V/s 139.48) (p<0.05). Significant negative correlation was seen in study group between serum copper levels and TC (r=-0.288, p<0.05), TG (r =-0.236, p<0.05), HDL (r=-0.946, p<0.05) and VLDL levels (r=0.102, p<0.05). This indicates that as copper level reduces lipids increases.

Conclusions:Our findings indicate the possible effect of Cu level in serum lipid profile and this effect may be due to the role of Cu as an antioxidant. The correlations between the serum concentrations of trace elements with lipid profile in physiological concentrations may not be the same as the changes observed during deficiencies of the trace elements as in hyperlipidemic patients

 


Keywords


Hyperlipidemia, Lipid profile, Lipoprotein, Serum copper, Trace elements

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References


Saraymen R, Kilic E, Yazar S, Saraymen B. Magnesium, copper, zinc, iron and chromium levels in sweat of boxers. Inonu Universitesi Tip Fakultesi Dergisi. 2003;10(3):121-5.

Suliburska J, Bogdański P, Pupek-Musialik D, Krejpcio Z. Dietary intake and serum and hair concentrations of minerals and their relationship with serum lipids and glucose levels in hypertensive and obese patients with insulin resistance. Biological trace element research. 2011 Feb 1;139(2):137-50.

Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes. New Engl J Medicine. 1992 Jan 30;326(5):310-8.

Angelova M, Asenova S, Nedkova V, Koleva-Kolarova R. Copper in the human organism. Trakia J Sci. 2011 Mar 1;9(1):88-98.

Ueshima H, Sekikawa A, Miura K, Turin TC, Takashima N, Kita Y, et al. Cardiovascular disease and risk factors in Asia: a selected review. Circulation. 2008 Dec 16;118(25):2702-9.

Khoo KL, Tan H, Liew YM, Deslypere JP, Janus E. Lipids and coronary heart disease in Asia. Atherosclerosis. 2003 Jul 1;169(1):1-0.

Abe A, Yiamashita S, Noma A. Sensitive, direct colorimetric assay for copper in serum. Clin Chem. 1989 Apr;35(4):552-4.

Medguard Professional healthcare supplies. Cobas lipid panel. Cobas B 101 POC System, V 4.0 Can English.

Zhao P, Liu S, Zhong Z, Liu J. Age-and sex-related difference of lipid profile in patients with ischemic stroke in China. Medicine. 2018 Jun;97(23).

Bushnell CD. Stroke and the female brain. Nat Clin Pract Neurol. 2008 Jan;4(1):22-33.

Chen RL, Balami JS, Esiri MM, Chen LK, Buchan AM. Ischemic stroke in the elderly: an overview of evidence. Nature Reviews Neurol. 2010 May;6(5):256.

Russo GT, Giandalia A, Romeo EL, Cucinotta D. Gender differences in lipoprotein metabolism. Italian J Gender-Speci Med. 2015 Oct 1;1(2):58-65.

Kolovou GD, Anagnostopoulou KK, Damaskos DS, Bilianou HI, Mihas C, Milionis HJ, et al. Gender differences in the lipid profile of dyslipidemic subjects. Europ J Intern Med. 2009 Mar 1;20(2):145-51.

Wang X, Magkos F, Mittendorfer B. Sex differences in lipid and lipoprotein metabolism: it's not just about sex hormones. J Clini Endocrinol Metabo. 2011 Apr 1;96(4):885-93.

Groot R, Hurk KVD, Schoonmade LJ, Kort WLAM, Brug J, Lakerveld J. Urban-rural differences in the association between blood lipids and characteristics of the built environment: a systematic review and meta-analysis. BMJ Global Health 2019;4(1).

Voskoboinik I, Camakaris J. Menkes copper-translocating P-type ATPase (ATP7A): biochemical and cell biology properties, and role in Menkes disease. J Bioenerg Biomem. 2002 Oct 1;34(5):363-71.

Yusuf S, Reddy S, Ôunpuu S, Anand S. Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation. 2001 Nov 27;104(22):2746-53.

Shokrzadeh M, Ghaemian A, Salehifar E, Aliakbari S, Saravi SS, Ebrahimi P. Serum zinc and copper levels in ischemic cardiomyopathy. Biolog Trace Element Resea. 2009 Feb 1;127(2):116.

Reunanen A, Knekt P, Marniemi J, Mäki J, Maatela J, Aromaa A. Serum calcium, magnesium, copper and zinc and risk of cardiovascular death. Europ J Clini Nutrition. 1996 Jul;50(7):431-7.

Lukaski HC, Klevay LM, Milne DB. Effects of dietary copper on human autonomic cardiovascular function. Europ J Appl Physiology Occupat Physiol. 1988 Jan 1;58(1-2):74-80.