Role of serum Vitamin-C and lipid profile in cardiovascular diseases patients of Southern Rajasthan

Parul Dhanak; Ashish Sharma; Neha Sharma

doi:10.18203/2320-6012.ijrms20194585

Authors

Parul Dhanak Department of Biochemistry, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India
Ashish Sharma Department of Biochemistry, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India
Neha Sharma Department of Biochemistry, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20194585

Keywords:

Ascorbic acid, Lipid profile, Lipoproteins, Trace elements

Abstract

Background: Vitamin C's functions as an antioxidant and as an enzyme cofactor are well established, but the ways in which these functions may modify chronic disease risk are less well established. The belief that vitamin C may benefit heart health has stemmed from multiple pieces of evidence and lines of reasoning. Thus, we took the objective of this study to evaluate the correlations of serum concentrations of trace elements including vitamin-C with lipid profile parameters of adult men in Southern Rajasthan.

Methods: Present study was conducted in Cardiology and Biochemistry Department in GMCH, Udaipur during the year 2019. A total of 150 MI cases/controls were selected. Blood sample was collected by vein puncture using an aseptic technique. The blood was allowed to settle at 37ºC and then centrifuged at 3000 rpm for 15 min. Serum was then separated and stored at -20ºC until analysis. Vitamin C by NATELSON method on colorimeter.

Results: The study cases had significantly higher lipid values than those of controls (p<0.001). In cases the vitamin-C levels were significantly low than the controls. There was significant difference in lipid levels among smokers and nonsmokers. When vitamin C levels were compared there was no statistically significant difference in their levels. There was no significant correlation between serum vitamin C levels and Lipids.

Conclusions: The physical characteristics such as diet, residence, smokers, non-smokers, showed significant difference in the controls and cases. Women seemed to have higher proportion of lipid abnormality than men. It is concluded from this study that lower levels of ascorbic acid definitely increase the risk of cardiovascular disease and inclusion of ascorbic acid in the normal diet will control the level of lipids.

Metrics

Metrics Loading ...

References

Ueshima H, Sekikawa A, Miura K, Turin TC, Takashima N, Kita Y, et al. Cardiovascular disease and risk factors in Asia: a selected review. Circulation. 2008 Dec 16;118(25):2702-9.

Limbu YR, Rai SK, Ono K, Kurokawa M, Yanagida JI, Rai G, et al. Lipid profile of adult Nepalese population. Nepal Med Coll J. 2008 Mar;10(1):4-7.

Wilson PW, D’Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998 May 12;97(18):1837-47.

Khoo KL, Tan H, Liew YM, Deslypere JP, Janus E. Lipids and coronary heart disease in Asia. Atherosclerosis. 2003 Jul 1;169(1):1-0.

Ridker PM. Risk factors for atherosclerotic disease. Heart disease: a textbook of cardiovascular medicine. 2001.

Hurst's the Heart, 11/e (2-volume set) 11th Edn by Valentin Fuster, R. Wayne, Alexander Robert A. O'Rourke, Robert Roberts, Spencer B. King Eric N. Prystowsky, Ira Nash, Eric Prystowsky.

Steinberg D, Parthasarathy 5, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 1989;320:915-24.

Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes. N Eng J Med. 1992 Jan 30;326(5):310-8.

Abe A, Yiamashita S Noma A. Sensitive, direct colorimetric assay for copper in serum. Clin Chem. 1989 Apr;35(4):552-4.

Medguard Professional healthcare supplies. Cobas lipid panel. Cobas B 101 POC System, V 4.0 Can English.

Natelson S. Determination of Ascorbic acid using 2, 4-Dinitrophenyl hydrazine. Techniques of Clinical Chemistry. 3rd ed, USA: Spring Field. 1971:165-6.

Zhao P, Liu S, Zhong Z, Liu J. Age-and sex-related difference of lipid profile in patients with ischemic stroke in China. Medicine. 2018 Jun;97(23).

Russo GT, Giandalia A, Romeo EL, Cucinotta D. Gender differences in lipoprotein metabolism. Italian J Gender-Specific Med. 2015 Oct 1;1(2):58-65.

Kolovou GD, Anagnostopoulou KK, Damaskos DS, Bilianou HI, Mihas C, Milionis HJ, et al. Gender differences in the lipid profile of dyslipidemic subjects. Europ J Internal Med. 2009 Mar 1;20(2):145-51.

Wang X, Magkos F, Mittendorfer B. Sex differences in lipid and lipoprotein metabolism: it's not just about sex hormones. J Clini Endocrinol Metabolism. 2011 Apr 1;96(4):885-93.

Jain RB, Ducatman A. Associations between smoking and lipid/lipoprotein concentrations among US adults aged ≥20 years. J Circulating Biomarkers. 2018 May 30;7:1-10.

Scicchitano P, Cameli M, Maiello M, Modesti PA, Muiesan ML, Novo S, et al. Nutraceuticals and dyslipidaemia: beyond the common therapeutics. J Functional Foods. 2014 Jan 1;6:11-32.

Wofford MR, Rebholz CM, Reynolds K, Chen J, Chen CS, Myers L, et al. Effect of soy and milk protein supplementation on serum lipid levels: a randomized controlled trial. Europ J Clini Nutrition. 2012 Apr;66(4):419-25.

Yusuf S, Reddy S, Ôunpuu S, Anand S. Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation. 2001 Nov 27;104(22):2746-53.