Histogenesis of human fetal kidney from 14 weeks to 36 weeks: a study

Divya Jain Pokarna, K. Kshitija, Seethamsetty Saritha


Background: The knowledge of fetal human Kidney morphology and developmental anatomy is very important for prenatal diagnosis of disorders such as Wilm’s tumor, hydronephroses and congenital malformation etc.

Methods: The study was carried out on 40 kidneys procured from 20 spontaneously aborted fetuses (11males and 9 females) ranging from 14wks-36wks of gestation, after confirming their age through  CRL they were grouped and then processed to form slides and stained with haemtoxylin and eosin and seen under light microscope.

Results: All kidneys were lobulated at early gestational age and became fused by 36 wks. Corticomedullary junction and preformed collecting tubules were seen clearly by 18wks. Well differentiated PCT and DCT were formed by 19-23 wks. Well-formed pyramids by 28 wks and medullary rays by 29 weeks were clearly distinguished. Loop of Henle developed and distinguished by 28 wks. Increased vascularity was seen by 32-36 wks. Nephrogenic zone and undifferentiated mesenchyme decreased and matured glomeruli increased by 36 wks.

Conclusions: The present study gave emphasis to the development of each component in medulla and cortex of kidney.




Corticomedullary junction, Distal Convolutes tubules, Intrauterine growth retardation, Loop of henle, Proximal convoluted tubules

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