Published: 2019-10-24

Clinical outcomes after percutaneous coronary intervention in patients with coronary artery disease: six months results from a single centre study

L. Kiran Kumar Reddy, Santhosh Satheesh


Background: The study aimed to evaluate clinical outcomes in patients with coronary artery diseases (CAD) who underwent percutaneous coronary intervention (PCI), to identify the factors associated with clinical outcomes and survival among such patients, to explore the procedure related complications, and to assess restenosis and stent thrombosis rates following PCI.

Methods: This retrospective, single-center, observational study was conducted at a tertiary-care center in India, which included patients with CAD undergoing PCI from January 2016 to December 2016. Angiographic and clinical success and complications related to both procedural and vascular access were noted. Patient were followed-up for clinical outcomes up to 6-months. Primary outcome of the study was all-cause mortality. Secondary outcome measures were cardiovascular mortality, and event free survival, angina, cardiovascular events and restenosis and stent thrombosis.

Results: A total of 831 patients were included of which majority were males (83.5%). Smoking was found in 33.7%, diabetes in 35.6%, and hypertension in 37.7%. At 6-months, follow-up was obtained for 711 patients. The clinical composite endpoint seen in 9.8% of patients. Angina (13.2%), acute coronary syndrome (3.1%), stent thrombosis (1.0%), in-stent restenosis (3.9%), cardiovascular and all-cause mortality (2.7%), heart failure (7.3%) and stroke (1.7%) were reported at 6-months follow-up.

Conclusions: The PCI in a tertiary-care centre leads to low rates of periprocedural events and low rates of clinical outcomes at 6-months follow-up. Moreover, left ventricular ejection fraction was shown to be major predictor for cardiovascular mortality in post-PCI patients. Hypertension was significantly associated with stroke post-PCI.


Drug eluting stents, Ejection fraction, Hypertension, Outcomes, Percutaneous coronary intervention

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Kelly BB, Fuster V, Ed. Promoting cardiovascular health in the developing world: a critical challenge to achieve global health. Natio Acade Pres. 2010.

Forouzanfar MH, Moran AE, Flaxman AD, Roth G, Mensah GA, Ezzati M, Naghavi M, Murray CJ. Assessing the global burden of ischemic heart disease: part 2: analytic methods and estimates of the global epidemiology of ischemic heart disease in 2010. Glob Heart. 2012;7(4):331-42.

Allali A, Holy EW, Sulimov DS, Toelg R, Richardt G, Abdel-Wahab M. Long-Term Clinical Outcome of Early Generation Versus New-Generation Drug-Eluting Stents in 481 Patients Undergoing Rotational Atherectomy: A Retrospective Analysis. Cardiol Thera. 2018;7(1):89-99.

Borhani S, Hassanajili S, Tafti SH, Rabbani S. Cardiovascular stents: overview, evolution, and next generation. Progr Biomater. 2018;7(3):175-205.

Iqbal J, Gunn J, Serruys PW. Coronary stents: historical development, current status and future directions. Br Med Bull. 2013;106(1):193-211.

Koskinas KC, Ughi GJ, Windecker S, Tearney GJ, Räber L. Intracoronary imaging of coronary atherosclerosis: validation for diagnosis, prognosis and treatment. Eur Heart J. 2015;37(6):524-35.

Subban V, Lakshmanan A, Victor SM, Pakshirajan B, Udayakumaran K, Gnanaraj A, et al. Outcome of primary PCI-An Indi tertiary care center experience. Indi Heart J. 2014;66(1):25-30.

Beig JR, Shah TR, Hafeez I, Dar MI, Rather HA, Tramboo NA, et al. Clinico-angiographic profile and procedural outcomes in patients undergoing percutaneous coronary interventions: The Srinagar registry. Indi Heart J. 2017;69(5):589-96.

Neumann FJ, Widimsky P, Belardi JA. One-year outcomes of patients with the zotarolimus-eluting coronary stent: RESOLUTE International Registry. Euro Intervention: J Euro PCR collab Working Group Inter Cardiol Eur Soci Card. 2012;7(10):1181-8.

Stone GW, Rizvi A, Newman W, Mastali K, Wang JC, Caputo R, et al. Everolimus-eluting versus paclitaxel-eluting stents in coronary artery disease. New Eng J Medi. 2010;362(18):1663-74.

Grube E, Chevalier B, Smits P, Džavík V, Patel TM, Mullasari AS, et al. The SPIRIT V study: a clinical evaluation of the XIENCE V everolimus-eluting coronary stent system in the treatment of patients with de novo coronary artery lesions. JACC: Cardiovas Intervent. 2011;4:168-75.

Kedhi E, Joesoef KS, McFadden E, Wassing J, Van Mieghem C, Goedhart D, et al. Second-generation everolimus-eluting and paclitaxel-eluting stents in real-life practice (COMPARE): a randomised trial. Lancet. 2010;375:201-9.

Raungaard B, Jensen LO, Tilsted H-H, Christiansen EH, Maeng M, Terkelsen CJ, et al. Zotarolimus-eluting durable-polymer-coated stent versus a biolimus-eluting biodegradable-polymer-coated stent in unselected patients undergoing percutaneous coronary intervention (SORT OUT VI): a randomised non-inferiority trial. Lancet. 2015;385:1527-35.

Zaman A, de Winter RJ, Kogame N, Chang CC, Modolo R, Spitzer E, et al. Safety and efficacy of a sirolimus-eluting coronary stent with ultra-thin strut for treatment of atherosclerotic lesions (TALENT): a prospective multicentre randomised controlled trial. Lancet. 2019;393:987-97.

Keelan PC, Johnston JM, Koru-Sengul T, Detre KM, Williams DO, Slater J, et al. Comparison of in-hospital and one-year outcomes in patients with left ventricular ejection fractions ≤40%, 41% to 49%, and≥ 50% having percutaneous coronary revascularization. Ame J cardiol. 2003;91:1168-72.

Sardi GL, Gaglia Jr MA, Maluenda G, Torguson R, Laynez-Carnicero A, Ben-Dor I, et al. Outcome of percutaneous coronary intervention utilizing drug-eluting stents in patients with reduced left ventricular ejection fraction. Ame J cardiol. 2012;109:344-51.

Mamas MA, Anderson SG, O'kane PD, Keavney B, Nolan J, Oldroyd KG, et al. Impact of left ventricular function in relation to procedural outcomes following percutaneous coronary intervention: insights from the British Cardiovascular Intervention Society. Eur heart J. 2014;35:3004-12.

Romagnoli E, Biondi-Zoccai G, Sciahbasi A, Politi L, Rigattieri S, Pendenza G, et al. Radial versus femoral randomized investigation in ST-segment elevation acute coronary syndrome: the RIFLE-STEACS (Radial Versus Femoral Randomized Investigation in ST-Elevation Acute Coronary Syndrome) study. J Ame College Cardiol. 2012;60:2481-9.