DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20194590

Bone metastasis from malignant phyllodes of the breast

Daniel Oktavianus Dau, I. Wayan Sudarsa

Abstract


Cystosarcoma phyllodes was described first in 1838 and originally was considered to be a benign tumor. It was not until 1931 that metastasis from a cystosarcoma phyllodes was reported. The incidence of cystosarcoma phyllodes is estimated to be 0.3% to 0.9% of all breast tumors. Sites most commonly affected by metastases are the lungs and bones. We present a case report  29-year old female patient presented with a voluminous breast mass at both of them  which was completely resected. The right side presented of malignant phyllodes and the left side is borderline phyllodes. Six months later, both of her legs became paralyzed and accompanied by swelling over her right upper arm. Biopsy was performed, and the diagnosis was metastatic malignant phyllodes tumor. Histologic review of the breast tumor revealed stromal overgrowth.


Keywords


Bone metastasis, Breast tumor, Malignant phyllodes, Stromal overgrowth

Full Text:

PDF

References


Kario K, Maeda S, Mizuno Y, Makino Y, Tankawa H, Kitazawa S. Phyllodes tumor of the breast: a clinicopathologic study of 34 cases. J Surgical Oncol. 1990 Sep;45(1):46-51.

Al-Zoubaidi M, Qiu S, Bonnen M, Bonnen M, Joyner M, Roehl K, et al. Malignant phyllodes tumor of the breast: A case report. Open Breast Cancer J. 2011;3:45-8.

De Sousa Rocha P, Wiseman Pinto RG, Nadkarni NS, Priolkar UV. Malignant phyllodes tumor metastatic to the forearm: a case report. Diagnostic cytopathology. 2000 Apr;22(4):243-5.

Tan PH, Jayabaskar T, Chuah KL, Lee HY, Tan Y, Hilmy M, et al. Phyllodes tumors of the breast: the role of pathologic parameters. Am J Clini Pathology. 2005 Apr 1;123(4):529-40.

Abemayor E, Nast CC, Kessler DJ. Cystosarcoma phyllodes metastatic to the mandible. J surgical Oncol. 1988 Dec;39(4):235-40.

Jones AA, Rizzolo SJ, Cotler JM, Star AM, Slemmer R. Metastatic cystosarcoma phyllodes associated with paraplegia: an uncommon complication of an uncommon tumor. J Spinal Disorders. 1993 Feb;6(1):71-5.

Ball AB, Fisher C. Bilateral malignant phyllodes tumours. J Surgical Oncology. 1991 Jan;46(1):67-9.

Guerrero MA, Ballard BR, Grau AM. Malignant phyllodes tumor of the breast: review of the literature and case report of stromal overgrowth. Surgical oncology. 2003 Jul 1;12(1):27-37.

Chen WH, Cheng SP, Tzen CY, Yang TL, Jeng KS, Liu CL, et al. Surgical treatment of phyllodes tumors of the breast: retrospective review of 172 cases. J Surgical Oncol. 2005 Sep 1;91(3):185-94.

Mouna B, Belbaraka R, Boutayeb S, Errihani H. The efficacy of chemotherapy against metastatic malignant phyllodes tumors of the breast. J Clinic Case Reports. 2012;2(6):122.

Salamoun WI. Malignant cystosarcoma phyllodes: an unusual presentation and review of the literature. Le Journal medical libanais. Lebanese Med J. 1993;41(1):40-3.

Ward RM, Evans HL. Cystosarcoma phyllodes. A clinicopathologic study of 26 cases. Cancer. 1986 Nov 15;58(10):2282-9.

Rainville E, Hanley KW. Metastatic cystosarcoma phyllodes. Acta cytologica. 1993;37(4):555-8.

Sapino A, Bosco M, Cassoni P, Castellano I, Arisio R, Cserni G, et al. Estrogen receptor-β is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast. Modern Pathology. 2006 Apr;19(4):599.

Altıntoprak F, Kıvılcım T, Dilek ON. Therapeutic Approachs To Breast Phyllodes Tumor, Eur J Gen Med. 2014 Jun 13;11(Suppl 1):7-10.