DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20195539

Variations of physiological parameters in newly detected hypothyroidism

Seethalakshmi K., Biju Bahuleyan, Sunil K. Menon

Abstract


Background: Emergence of hypothyroidism as a public health issue apart from a common clinical entity, has gained much attention nowadays. The non-specific features of hypothyroidism lead to incorrect diagnoses, inadequate treatment and complications in the future. The present study was designed to unravel the effects of hypothyroidism on physiological parameters and to highlight the importance of early diagnosis and treatment. This study was done to assess the effects of hypothyroidism on pulse rate, blood pressure and respiratory rate.

Methods: This descriptive cross-sectional study was done in 60 hypothyroid patients of 18-45 years age, both males and females, who were either newly detected or on treatment for less than 6 months. Patients with history of other systemic diseases, pregnancy and hyperthyroidism were excluded. After obtaining written consent from the patients, clinical examination was done.

Results: Student t-test and ANOVA were used for analysis. Physiological parameters like pulse rate, blood pressure and respiratory rate had variations in the patients and there were changes with age, gender and BMI even though they were not significant. These changes were attributed to increased arterial wall thickness and endothelial dysfunction in blood vessels.

Conclusions: The patients showed changes in cardiovascular and respiratory profiles. The variations in systolic and diastolic blood pressures were significant with increase in age. Physiological parameters had variations with gender and BMI also. This proves the cardiovascular and respiratory morbidity in newly detected hypothyroidism, which emphasizes the importance of early diagnosis and treatment in them.


Keywords


Age, Body mass index, Gender, Hypothyroidism, Physiological

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References


Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012 Dec 15;380(9859):2095-128.

Kalra S, Unnikrishnan AG, Sahay R. The global burden of thyroid disease. Thy Res Pra. 2013 Sep 1;10(3):89-90.

Park K. Park's textbook of preventive and social medicine. 23rd edition. India : Bhanot Publishers; 2015:643.

Unnikrishnan AG, Menon UV. Thyroid disorders in India: An epidemiological perspective. Ind J Endocrinol Meta. 2011 Jul;15(2):S78.

Fazio S, Palmieri EA, Lombardi G, Biondi B. Effects of thyroid hormone on the cardiovascular system. Recent Pro Horm Res. 2004 Jan 1;59(1):31-50.

Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. New Engl J Med. 2001 Feb 15;344(7):501-9.

Ochs N, Auer R, Bauer DC, Nanchen D, Gussekloo J, Cornuz J, et al. Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality. Annal Int Med. 2008 Jun 3;148(11):832-45.

Klein I, Ojamaa K. The cardiovascular system in hypothyroidism. In: Braverman LE, Utiger RD, eds. Werner and Ingbar’s The Thyroid: A Fundamental and Clinical Text. 8th ed. Philadelphia: Lippincott Williams and Wilkins; 2000:777-782.

Ladenson PW. The heart and thyroid disease. The Mount Sinai J Med, New York. 1996 Mar;63(2):118.

Simmonds MJ, Kavvoura FK, Brand OJ, Newby PR, Jackson LE, Hargreaves CE, et al. Skewed X chromosome inactivation and female preponderance in autoimmune thyroid disease: an association study and meta-analysis. J Clin Endocrinol Meta. 2014 Jan 1;99(1):E127-31.

Manji N, Carr-Smith JD, Boelaert K, Allahabadia A, Armitage M, Chatterjee VK, et al. Influences of age, gender, smoking, and family history on autoimmune thyroid disease phenotype. J Clini Endocrinol Meta. 2006 Dec 1;91(12):4873-80.

Åsvold BO, Bjøro T, Nilsen TI, Vatten LJ. Association between blood pressure and serum thyroid-stimulating hormone concentration within the reference range: a population-based study. J Clin Endocrinol Meta. 2007 Mar 1;92(3):841-5.

Roel S, Punyabati O, Prasad L, Salam R, Ningshen K, Shimray AJ, et al. Assessment of functional lung impairment in hypothyroidism. IOSR J Dent Med Sci. 2014;13:4-7.

Gluvic Z, Sudar E, Tica J, Jovanovic A, Zafirovic S, Tomasevic R, et al. Effects of levothyroxine replacement therapy on parameters of metabolic syndrome and atherosclerosis in hypothyroid patients: a prospective pilot study. Int J Endocrinol. 2015.

Dernellis J, Panaretou M. Effects of thyroid replacement therapy on arterial blood pressure in patients with hypertension and hypothyroidism. Am heart J. 2002 Apr 1;143(4):718-24.

Ladenson PW, Kieffer JD, Farwell AP, Ridgway EC. Modulation of myocardial L-triiodothyronine receptors in normal, hypothyroid, and hyperthyroid rats. Meta Clin Exp. 1986 Jan 1;35(1):5-12.

Dillmann WH. Biochemical basis of thyroid hormone action in the heart. Am J Med. 1990 Jun 1;88(6):626-30.

Bassi R, Dhillon SK, Sharma S, Sharma A, Tapdiya M. Effect of thyroid hormone replacement on respiratory function tests in hypothyroid women. Pak J Physiol. 2012;8(2):20-3.

Warren M. Gold M. Pulmonary Function Tests. In: Murray JF, Nadel JA, Eds. Textbook of Respiratory Medicine. 3rd ed. Philadelphia: WB. Saunders Co;2000;781-785.

Sharifi F, Amari A. The effect of levothyroxine on pulmonary function tests of hypothyroid patients. Int J Endocrinol Meta. 2005;1:48-51.