DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20195559

Paracetamol induced bullous fixed drug eruptions

Kalyani Pai Kakode, Varun Pai Kakode

Abstract


Paracetamol is a commonly used antipyretic and analgesic with a weak anti-inflammatory action with a good safety profile in children and adults. This has resulted in its over prescription and large over the counter sale. Thus, adverse drug reactions due to paracetamol may be easily overlooked resulting in delay in diagnosis. Author present a case report of a 12 year old boy with bullous fixed drug eruptions due to paracetamol while he tolerated NSAIDS well. This highlights the need of adverse drug reaction monitoring and reporting, for early detection and prompt treatment of drug related morbidity and the cautious use of even the most commonly used drugs.


Keywords


Bullous fixed drug eruptions, Idiosyncratic reactions, Paracetamol allergy, Paracetamol

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References


Grosser T, Smyth E, FitzGerald GA. Anti-inflammatory, antipyretic, and analgesic agents; pharmacotherapy of gout. Goodman and Gilman's the pharmacological basis of therapeutics. 2011;12:959-1004.

Girisha BS, Noronha TM, Alva AC, Menon A. Generalized bullous fixed drug eruption mimicking toxic epidermal necrolysis caused by paracetamol. Clini Dermatol Rev. 2018;2(1):34.

Daulatabadkar B, Pande S, Borkar M. Generalized bullous fixed drug reaction: A close similarity to stevens-johnson syndrome. Ind J Drugs Dermatol. 2017;3(1):28.

Srinivas SM, Shekar R, Gnanamurthy N. Fixed drug eruption to paracetamol in a child. Ind J Paediatr Dermatol. 2018;19(4):386.

Thompson G, Bundell C, Lucas M. Paracetamol allergy in clinical practice. Aus J Gen Pract. 2019;48(4):216.

Mahajan VK, Handa S. Patch testing in cutaneous adverse drug reactions: methodology, interpretation, and clinical relevance. Ind J Dermatol, Venereol, Leprol. 2013;79(6):836.