DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20161211

Histopathology of endometrium in abnormal uterine bleeding, in correlation with thyroid profile and ultrasonography findings

Parvathi Gorla, Sridevi Sanapala, Eswari Devi, Bhagya Lakshmi Atla, Manasa Rasaputra

Abstract


Background: Abnormal uterine bleeding is the cause for many disturbances in women who are in the reproductive age group. Frequent and prolonged periods will lead to morbidity, social embarrassment, diminished quality of life and compromise of the sexual life.

Methods: It is a hospital based cross sectional study conducted in the department of pathology, Andhra medical college. A total of 270 patients in the age group of 18 to 45 years were included in this study. Endometrial samples were obtained and histopathological examinations were conducted. All the clinical details and investigation reports were collected.

Results: The age group of patients in this study ranged from 18 to 45 years. Maximum numbers of cases (169) were in the age group of 36 to 45 years (62.6%). Most of the patients were multipara (244 cases, 90.37%) and most common presenting complaint was heavy menstrual bleeding (198 cases, 73.3%). Majority of the patients were euthyroid (247 cases, 91.5%). Normal cyclical endometrium was found to be the commonest histopathological pattern with proliferative endometrium in 45.56% and secretory endometrium in 32.59% cases. Leiomyomas were found to be the commonest cause of abnormal uterine bleeding (15.56%). Bulky / enlarged uterus (77%) and type-IV (hyperechoic) endometrium, depicting the secretory endometrial pattern (36.66%) was the most common finding on transvaginal sonography (TVS).

Conclusions: Histopathological examination is the gold standard for studying the pattern of endometrium in various causes of abnormal uterine bleeding.


Keywords


Endometrium, Uterine bleeding, Thyroid, Ultrasonography

Full Text:

PDF

References


Cullen W. First lines of the practice of physic. Edinburgh: Balfour & Bradfute; 1816.

Chabra S, Jaswal M, Nangia V. Uterine size, Endometrium Fertility in women with dysfunctional uterine haemorrhage. J Obstet Gynecol India. 1992; 42:692-4.

American college of obstetrician and gynecologists committee on practice bulletins gynecology, management of anovulatory bleeding; clinical management guidelines for obstetrician-gynaecologists.practicebulletin. Washington, DC; ACOG2000.

Fleischer AC, Kalemeris G, Machin J, Entman SS, James AE Jr. Sonographic depiction of normal and abnormal endometrium with histopathologic correlation. J Ultrasound Med. 1986;5:445-52.

Singh A, Singh S, Mathur V, Singh K. Transvaginal-sonography in DUB and correlation with histopathology. Journal of obstetrics and gynecology of India. 2001;51(6):116-9.

Doraiswami S, Johnson T, Panicker VK. Study of endometrial pathology in abnormal uterine bleeding. J Obstet Gynecol India. 2011;61(4):426-30.

Dadhania B, Dhruva G, Agravat A, Pujara K. Histopathological study of endometrium in dysfunctional uterine bleeding. Int J Res Med. 2013;2(1);20-4.

Veena A, Seema M, Anitha R. Evaluation of dysfunctional uterine bleeding by transvaginalsonography hysteroscopy and histopathology. J of Obst and Gyn of India. 2003;53(2):170-7.

Parmar J, Desai D. Study of endometrial pathology in abnormal uterine bleeding. Int J Reprod Contracept Obstet Gynecol. 2013;2(2):182-5.

Kaur T, Aseeja V, Sujatha Sharma S. Thyroid dysfunction in dysfunctional uterine bleeding, Webmed Central Obstertics and Gynecology 2011;2(9):1-7.

Pahwa S, Guptha S, Kaur J. Thyroid dysfunction in dysfunctional uterine bleeding. JARBS. 2013;5(1):78-83.

Sharma N, Sharma A. Thyroid profile in menstrual disorders. Jkscience. 2012;14:14-17.