DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20195903

Seroreactivity of HIV among patients attending a tertiary care hospital in North India: a retrospective analysis

Noor Jahan, Akanksha Singh, Deepak Chopra, Sarver Jahan, Razia Khatoon

Abstract


Background: HIV (Human Immunodeficiency Virus) is the causative agent of AIDS (Acquired Immunodeficiency Syndrome). It belongs to the lentivirus subgroup of the family Retroviridae. The HIV/AIDS is spreading worldwide at an alarming rate. India has the third largest number of estimated people living with HIV/AIDS. Most common mode of HIV transmission is through heterosexual contact, blood transfusion, percutaneous, mucosal and perinatal mode. The present study was done to evaluate the seroreactivity of HIV among patients attending Integrated Counselling and Testing Centre (ICTC) of our Tertiary care hospital.  

Methods: This retrospective study was conducted on data of patients who had attended ICTC and undergone HIV testing from January 2017 to January 2019. A total of 4519 patients were included in the study who gave their consent followed by pre-test and post-test counseling and were screened for HIV antibody by using rapid kit Comb-Aids.

Results: Out of 4519 samples tested, 23 were reactive to HIV screening test, hence sero-reactivity of HIV was found to be 0.50%. Higher seroreactivity was seen among males (56.5%, 13/23), and patients aged 31-40 years (39.1%, 9/23). Maximum seroreactivity was found among patients of rural areas (73.9%, 17/23), indoor patients (91.3%, 21/23) and married patients (73.9%, 17/23).

Conclusions: In this study the seroreactivity of HIV was found to be low among patients attending ICTC but still HIV continues to be a major contributor to the global burden of disease. ICTC data can be used as an important tool for planning and improving the national HIV/AIDS intervention strategy.


Keywords


Comb-Aids, Human immunodeficiency virus, Retrospective, Sero-reactivity

Full Text:

PDF

References


National AIDS Control Organization and National Institute of Medical Statistics, ICMR. India HIV Estimations 2015. New Delhi: NACO; 2015. Available at: http://naco.gov.in/sites/default/files/India%20HIV%20Estimations%202015.pdf. Accessed 10 October 2019.

Franscisco AD. HIV/AIDS: Global forum for Health Research. The 10/90 report on Health Research; 2001-2002:146-9.

Welfare F. Prevention of Parent to Child Transmission (PPTCT) of HIV using Multi Drug Anti-retroviral Regimen in India; National Guidelines for Prevention of Parent-to-Child Transmission of HIV, 2013:137.

Newell M, Coovadia H, Cortina-Borja M, Rollins N, Gaillard P, Dabis F. Mortality of infected and uninfected infants born to HIV- infected mothers in Africa: a pooled analysis. Lancet. 2004,364:1236-43.

Ndirangu J, Newell ML, Tanser F, Herbst AJ, Bland R. Decline in early life mortality in a high HIV prevalence rural area of South Africa: evidence of HIV prevention or treatment impact? AIDS 2010; 24(4):593-602.

Chakraborty MS, Chakraborty A. Tuberculosis and HIV illness. J Indian Med Assoc. 2000;98:103-6.

Manipur State AIDS control society. Available at: http://manipursacs.nic.in/ Accessed 2013.

Clottey C, Dallabetta G. Sexually transmitted diseases and human immunodeficiency virus. Epidemiologic synergy? Inf Dis Clin North Am. 1993; 7:753-70.

AIDS Epidemic Update: World Health Organization, December 2006. Available at: https://www.who.int/hiv/pub/epidemiology/epiupdate2006/en/. Accessed 12 October 2019.

Technical report - India HIV estimates - 2006. New Delhi, ICMR. National Institute of Medical Statistics. National AIDS Control Organization. Available at: http://data.unaids.org/pub/report/2007/india_hiv_estimates_report_2006_en.pdf. Accessed 14 October 2019.

Ashtagi GS, Metgud CS, Walvekar PR, Naik VA. Prevalence of HIV among rural pregnant women attending PPTCT services at KLE hospital, Belgaum. Al Ameen J Med Sci. 2011;4:45-8.

Sarkate P, Paranjpe S, Ingole N, Mehta P. Monitoring HIV Epidemic in pregnant women: Are the current measures enough? J Sexu Transm Dis. 2015:194831.

NACO, Department of AIDS control, Ministry of Health and Family welfare, Annual Report 2012-2013. Government of India. Available at: http://naco.gov.in/sites/default/files/Annual%20report%202012-13_English.pdf. Accessed 16 October 2019.

Solomon S, Ganesh AK. HIV in India. Int AIDS Soci - USA Topics HIV Med. 2002;10:19-24.

India against AIDS: Aspiring for “AIDS Free India” |National Portal of India. Available at: https://www.india.gov.in/spotlight/india-against-aids-aspiring-aids-free-india. Accessed 18 October 2019.

Mandel S, Bhattacharya RN, Chakraborty M, Pal PP, Roy SG, Mukherjee G. Evaluation of the prevention of parent to child transmission program in a rural tertiary care hospital of West Bengal, India. Ind J Commin Med. 2010;35:491-4.

Giri PA, Bangal VB, Phalke DB. Prevalence of HIV among rural pregnant women attending antenatal clinics at Pravara Rural Hospital, Loni, Maharashtra, India. Int J Health Allied Sci 2012;1:13-5.

Devi A, Shyamala R. The study of seroprevalence of HIV in pregnant women in a teriary care hospital. Pharm Lett. 2012;4:1835-36.

Patil VM, Moray AP, Patil SP. Ten years trend of HIV seroprevalence among Indian pregnant women attending antenatal clinic at a tertiary hospital in Dhule, Maharashtra, India. IJRCOG. 2016;5(5):1514-9.

Kulkarni S, Doibale M. Trend of seroprevalence of HIV among antenatal clinic attendees at a tertiary care hospital. Int J Basic Appl Med Sci. 2013;3(1):257-62.

Sibia P, Mohi MK, Kumar A. Seroprevalence of Human Immunodeficiency Virus among Antenatal women in one of the institutes of Northern India. J Clin Diag Res. 2016;10:8-9.

Laghawe A, Faujdar SS. Declining trends in HIV prevalence: A tertiary care hospital based 05 years retrospective analysis. Int J Curr Microbiol Appl Sci. 2015;4:927-36.

Malhotra S, Sharma S, Hans C. Recent trend of HIV infection at ICTC in a tertiary care hospital in North India. Archiv Med. 2015;7:1- 4.

Sayare PC, Ambhore NA, Mantri RS, Karyakarte RP. Prevalence of HIV infection among pregnant women in a tertiary care hospital Akola, India. Int J Curr Microbiol Appl Sci 2017;6:691-6.

Ambhore NA, Sayare PC, Karyakarte RP, Mantri RS. Trends of seroprevalence and epidemiology of HIV infection: A five year Tertiary care hospital based study. Int J Curr Microbiol Appl Sci, 2016;5:733-40.