The flickering jaundice

Authors

  • Cynthia Amrutha Department of Medicine, Kasturba Medical College, Manipal, Karnataka, India
  • Shipra Rai Department of Medicine, Kasturba Medical College, Manipal, Karnataka, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20200269

Keywords:

Benign jaundice, Benign Recurrent Intrahepatic cholestasis, Cholestatic jaundice, Recurrent jaundice

Abstract

Benign Recurrent Intrahepatic Cholestasis (BRIC) is a rare autosomal recessive disorder characterized by intermittent episodes of jaundice and pruritus. It is also known as Summerskill-Walshe-Tygstrup syndrome. It is a benign disease with no progression to end stage liver disease.. The first episode of cholestatic jaundice occurs early in life and there are asymptomatic periods between attacks lasting weeks to years. This case report presents a young male who presented with severe pruritus and acute onset jaundice. He had his first episode of jaundice at the age of twelve and had several intermittent episodes since then. Diagnosis was made by the unique clinical presentation with exclusion of other causes of cholestatic jaundice. This case report highlights the importance of detecting such cases of rarity and preventing unnecessary invasive diagnostic procedures on such patients.

References

Summerskill WHJ, Walsh JM. Benign recurrent intrahepatic obstructive jaundice. Lancet 1959;2:686-90.

Tygstrup N, Jensen B. Intermittent intrahepatic cholestasis of unknown aetiology in five young males from the Faroe Islands. Acta Med Scand 1969;185:523-30.

Bull LN, van Eijk MJ, Pawlikowska L, DeYoung JA, Juijn JA, Liao M, et al. A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis. Nat Genet. 1998;18:219-24.

Van der Woerd WL, van Mil SWC, Stapelbroek JM, Klomp LWJ, van de Graaf SFJ, Houwen RHJ. Familial cholestasis: progressive familial intrahepatic cholestasis, benign recurrent intrahepatic cholestasis and intrahepatic cholestasis of pregnancy. Best Pract Res Clin Gastroenterol. 2010;24:541-53.

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Published

2020-01-27

How to Cite

Amrutha, C., & Rai, S. (2020). The flickering jaundice. International Journal of Research in Medical Sciences, 8(2), 757–759. https://doi.org/10.18203/2320-6012.ijrms20200269

Issue

Section

Case Reports