Published: 2020-01-27

Clinico-pathological analysis of lymphoproliferative disorders: a 3 year study

K. Rajasree Varma, Farzana T., Sunitha Thomas, Latha K. Abraham


Background: The incidence of lymphoproliferative disorders has increased in many parts of the world. Newer subtypes have been identified by the new WHO classification. Accurate subtyping of lymphomas is crucial for prompt treatment. Objective of the study was to assess the clinicopathological pattern of lymphoproliferative diseases diagnosed in Rajagiri hospital over a period of 3 years.

Methods: A retrospective study on all patients who were diagnosed with lymphoma in Rajagiri hospital during January 2016 to December 2018 was conducted and the data were reviewed and analyzed.

Results: A total of 151 patients were included in the study. Majority of the subjects (63%) were males. The predominant age group affected was 61-80 years. Mean age group was 58.46 years (SD=19.05 years). Most common presenting symptom was painless lymphadenopathy. B symptoms were seen in 18% of subjects and was found to be more commonly associated with B cell Non-Hodgkin lymphoma. Most common lymph node involved was cervical lymph node, while the most common extra nodal site was bone marrow. Most common lymphoproliferative disorder was Diffuse large B cell Lymphoma. Lymph node involvement was found in 74% of patients, while hepatomegaly and splenomegaly were seen in 11% and 18.5% of patients. 20% of patients had secondary bone marrow involvement. 8 patients developed recurrent lesions involving other organs.

Conclusions: Clinicopathologic patterns of lymphoproliferative disorders vary across various regions. A proper understanding of demographical distribution of lymphomas is very essential, as it can provide valuable clues for accurate diagnosis and treatment.


Bone marrow involvement, Cervical lymphadenopathy, Diffuse large B cell lymphoma, Follicular lymphoma, Peripheral T cell lymphoma, Splenomegaly

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Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Inter J Cancer. 2015 Mar 1;136(5):E359-86.

Nair R, Arora N, Mallath MK. Epidemiology of non-Hodgkin's lymphoma in India. Oncol. 2016;91(1):18-25.

Prakash G, Sharma A, Raina V, Kumar L, Sharma MC, Mohanti BK. B cell non-Hodgkin’s lymphoma: experience from a tertiary care cancer center. Annal Hematol. 2012 Oct 1;91(10):1603-11.

Chakrabarti S, Sarkar S, Goswami BK, Mondal S, Roy A, Das S. Hodgkin’s and Non-Hodgkin’s lymphomas in an Indian rural medical institution: comparative clinicopathologic analysis. Asian Pac J Cancer Prev. 2010 Jan 1;11(6):1605-8.

Devi AA, Sharma TD, Singh YI, Sonia H. Clinicopathological profile of patients with non-hodgkin's lymphoma at a regional cancer center in Northeast India. J Sci Soci. 2017 Sep 1;44(3):140.

Neeravari VS, Bannigidad D, Kushtagi AV, Rao L. Clinical spectrum of non-Hodgkin lymphoma: A hospital-based study of 410 Cases. Annal Appl Bio-Sci. 2016 Feb 29;3(1):2455-0396.

Nimmagadda RB, Digumarti R, Nair R, Bhurani D, Raina V, Aggarwal S, et al. Histopathological pattern of lymphomas and clinical presentation and outcomes of diffuse large B cell lymphoma: a multicenter registry-based study from India. Ind J Med Paediatr Oncol. 2013;34:299-304.

Krol AD, Le Cessie S, Snijder S, Kluin-Nelemans JC, Kluin PM, Noordijk EM. Primary extranodal non-Hodgkin’s lymphoma (NHL): the impact of alternative definitions tested in the Comprehensive Cancer Centre West population-based NHL registry. Annal Oncol. 2003 Jan 1;14(1):131-9.

Bhatia P, Das R, Ahluwalia J, Malhotra P, Varma N, Varma S, et al. Hematological evaluation of primary extra nodal versus nodal NHL: A study from North India. Ind J Hematol Blood Trans. 2011 Jun 1;27(2):88-92.

Conlan MG, Armitage JO, Bast M, Weisenburger DD. Clinical significance of hematologic parameters in non‐Hodgkin's lymphoma at diagnosis. Cancer. 1991 Mar 1;67(5):1389-95.

Mishra P, Das S, Kar R, Jacob SE, Basu D. Primary extranodal non-Hodgkin lymphoma: A 3-year record-based descriptive study from a tertiary care center in Southern India. Ind J Pathol Microbiol. 2015 Jul 1;58(3):296.

Aziz Z, Rehman A, Akram M, Saeed A. Non-Hodgkin's lymphoma in Pakistan: a clinicopathological profile of 175 patients. J Pakistan Med Assoc. 1999 Jan;49:11-5.

Naresh KN, Srinivas V, Soman CS. Distribution of various subtypes of non-Hodgkin's lymphoma in India: a study of 2773 lymphomas using REAL and WHO Classifications. Annal Oncol. 2000 Jan 1;11(1):S63-7.

Sahni CS, Desai SB. Distribution and clinicopathologic characteristics of non-Hodgkin's lymphoma in India: A study of 935 cases using WHO classification of lymphoid neoplasms (2000). Leukem Lymp. 2007 Jan 1;48(1):122-33.

Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. New Eng J Med. 2002 Jun 20;346(25):1937-47.

Gogia A, Das CK, Kumar L, Sharma A, Sharma MC, Mallick S. Profile of non-Hodgkin lymphoma: An Indian perspective. South Asian J Cancer. 2018 Jul;7(3):162.

Shi YF, Li XH, Song YQ, Song WW, Lai YM. Involvement of bone marrow in lymphoma: pathological investigation in a single-center from northern China. Inter J Clin Exper Pathol. 2015;8(6):7102.