Pulmonary functions in type 2 diabetes mellitus patients: an observational study at a tertiary level hospital in Mumbai, Maharashtra, India

Shilpa Karande; Sangeeta J. Pednekar; S. T. Nabar; Arunab Mehta; Vasanti Iyengar

doi:10.18203/2320-6012.ijrms20161229

Authors

Shilpa Karande Department of Medicine, Asthma & COPD Clinic, T. N. Medical College & B. Y. L. Ch. Nair Hospital, Mumbai
Sangeeta J. Pednekar Department of Medicine, Lokmanya Tilak Municipal Medical College, Sion, Mumbai
S. T. Nabar Department of Medicine, Asthma & COPD Clinic, T. N. Medical College & B. Y. L. Ch. Nair Hospital, Mumbai
Arunab Mehta Department of Medicine, Asthma & COPD Clinic, T. N. Medical College & B. Y. L. Ch. Nair Hospital, Mumbai
Vasanti Iyengar Spirometry Technician, Department of Medicine, T. N. Medical College & B. Y. L. Ch. Nair Hospital, Mumbai

DOI:

https://doi.org/10.18203/2320-6012.ijrms20161229

Keywords:

Diabetes, Microangiopathy, Peripheral neuropathy, Pulmonary function test

Abstract

Background: Pulmonary complications of diabetes mellitus (DM) have been poorly characterized. A reduction in lung capacity has been reported previously in diabetics. We undertook a study to check the association between pulmonary function tests in type 2 DM. Also to determine their correlations with body mass index (BMI), glycemic control and other clinically evident complications like peripheral neuropathy.

Methods: The study was conducted at tertiary care BYL Nair hospital, Mumbai where diabetic patients without any hypertension, cardiovascular disease, primary respiratory abnormalities and without any microangiopathic complications were enrolled. They were clinically evaluated for pulse, blood pressure, skin changes, BMI and various biochemical investigations. Blood sugar- fasting and post prandial, serum cholesterol, serum triglyceride, urinary proteins, electrocardiograph, X- ray chest were noted. Pulmonary function test was performed by spirometry. Peripheral neuropathy was looked for an association with pulmonary function tests (PFT).

Results: Out of 200 patients 68% (136) patients had normal PFT, mild obstruction 10.0% (20), mild restriction 10% (20) moderate obstruction 2% (4), moderate restriction 4% (8) and mixed 6% (12) were noted. FEV1, FVC values were statistically significantly reduced in patients with peripheral neuropathy and FEV1/FVC % significantly decreased with increasing duration of diabetes.

Conclusions: The present study shows that there is a statistically significant association between PFTs and type 2 DM in Indian patients. Pathologically it may be attributed to microangiopathic complications.

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References

Mohan V, Sandeep S, Deepa R, Shah B, Varghese C. Epidemiology of type 2 Diabetes: Indian Scenario. Indian J Med Res. 2007;125:217-30.

Sinha S, Guleria R, Misra A, Pandey RM, Yadev R, Tiwari S. Pulmonary functions in patients with type 2 diabetes mellitus and correlation with anthropometry and micro vascular complications. Indian J Med Res. 2004;119:66-71.

Davis AW, Knuiman M, Kendall P, Grange v, Davis TME. Glycemic exposure is associated with reduced pulmonary function in type 2 diabetes. Diabetic Care. 2004;27:252-7.

India stats: million plus cities in India as per Census 2011. Press Information Bureau, Mumbai (Press release). Press Information Bureau, Government of India. 31 October 2011.

Marvisi M, Bartolini L, del Borrello P, Brianti M, Marani G, Guariglia A. Pulmonary Function in non-insulin dependent diabetes mellitus. Respiration. 2001;68:268-72.

Ljunic S, Metelko Z, Car N, Rogli G, Drazic Z. Reduction of diffusion capacity for carbon monoxide in diabetic patients. Chest. 1998;114: 1033-5.

Isotani H, Nakamura Y, Kameoka K, Tanaka K, Furukakawa K, Kitaoka H. Pulmonary diffusion capacity, serum angiotensin-converting enzyme activity and angiotensin-converting enzyme gene in Japanese non-insulin-dependent diabetes mellitus patients. Diabetes Res Clin Pract. 1999;43:173-7.

Benbassat CA, Stern E, Kramer M, Lebzetter J, Blum I, Fink G. Pulmonary Function in patients with diabetes mellitus. Am J Med Sci. 2001;322: 127-32.

Creager M, Luscher T, Cosentino F, Beckman J. Diabetes and Vascular Disease: Pathophysiology, Clinical Consequences and medical therapy part I. Circulation. 2003;108:e81-5.