Levels of serum lithium in manic depressive patients with mild persistent bronchial asthma
Keywords:Bronchial asthma, Lithium, Manic depressive
Background: Lithium, widely used in manic depressive (MD) patients, might protect the airways against constrictor stimuli in bronchial asthma (BA), through its effects on cell signal transduction and ion transport pathways.
Methods: Serum lithium levels were studied in MD patients with better controlled mild persistent BA (group A) and MD patients with not so well controlled BA (group B).
Results: Serum lithium levels were highly significantly more in group A compared to lithium levels in group B.
Conclusions: Lithium may inhibit the contractile response of airway smooth muscle and can be used in treatment / monitoring of BA.
Kwak YG, Song CH, Yi HK, Hwang PH, Kim JS, Lee KS, et al. Involvement of PTEN in airway hyper-responsiveness and inflammation in bronchial asthma. J Clin Invest. 2003;111(7):1083-92.
Aggarwal AN, Chaudhry K, Chhabra SK, D'Souza GA, Gupta D, Jindal SK, et al. Asthma epidemiology study group. prevalence and risk factors for bronchial asthma in Indian adults: a multicentre study. Indian J Chest Dis Allied Sci. 2006;48(1):13-22.
Dusser D, Montani D, Chanez P, Blic J, Delacourt C, Deschildre A, et al. Mild asthma: an expert review on epidemiology, clinical characteristics and treatment recommendations. Allergy. 2007;62(6):591-604.
Pearce N, Douwes J, Beasley R. Is allergen exposure the major primary cause of asthma? Thorax. 2000;55(5):424-31.
Cohn L, Elias JA, Chupp GL. Asthma: mechanisms of disease persistence and progression. Annu Rev Immunol. 2004;22:789-815.
Dinan TG. Lithium in bipolar mood disorder. BMJ. 2002;324(7344):989-90.
Knox AJ, Higgins BG, Hall IP, Tattersfield AE. Effect of oral lithium on bronchial reactivity in asthma. Clin Sci. 1992;82(4):407-12.
Andreasen NC, Grove WM, Shapiro RW, Keller MB, Hirschfeld RM, Scott P. Reliability of lifetime diagnosis a multicenter collaborative perspective. Arch Gen Psychiatry. 1981;38(4):400-5.
Pelaia G, Renda T, Gallelli L, Vatrella A, Busceti MT, Agati S, et al. Molecular mechanisms underlying airway smooth muscle contraction and proliferation: implications for asthma. Respir Med. 2008;102(8):1173-81.
Sampson SR, Weiss RC. Relaxant effects of lithium on guinea pig tracheal smooth muscle in vitro. Br J Pharmacol. 1982;75:287-91.
Nasr SJ, Atkins RW. Coincidental improvement in asthma during lithium therapy. Am J Psychiatry. 1977;134:1042-3.
Dai JM, Kuo KH, Leo JM, Pare PD, Breemen C, Lee CH. Acetylcholine-induced asynchronous calcium waves in intact human bronchial muscle bundle. Am J Respir Cell Mol Biol. 2007;36:600-8.
Hirota SA, Janssen LJ. Sodium and asthma: something borrowed, something new? Am J Physiol Lung Cell Mol Physiol. 2007;293:1369-73.
Pelaia G, Gallelli L, Vatrella A, Grembiale RD, Maselli R, Sarro GB. Potential role of potassium channel openers in the treatment of asthma and chronic obstructive pulmonary disease. Life Sci. 2002;70(9):977-90.
Rosenqvist M, Bergfeldt L, Aili H, Mathe AA. Sinus node dysfunction during long term lithium treatment. Br Heart. 1993;70:371-5.
Michalik M, Wójcik KA, Jakieła B, Szpak K, Pierzchalska M, Sanak M, et al. Lithium attenuates tgf-β(1)-induced fibroblasts to myofibroblasts transition in bronchial fibroblasts derived from asthmatic patients. J Allergy. 2012;206:10-9.