Helicobacter pylori infection among type 2 diabetics: a case control study
DOI:
https://doi.org/10.18203/2320-6012.ijrms20200779Keywords:
Diabetes mellitus, Dyspepsia, Epigastric burning, Helicobacter pylori, RegurgitationAbstract
Background: Helicobacter pylori infection has been associated with hyperglycemia among type 2 diabetics. The objective of this study was to compare the H. pylori infection frequency in diabetic and non-diabetic patients.
Methods: This case-control study was done at Al-Tibri Medical College and Hospital from May 2019 to August 2019. After written and informed consent, patients between 18-75 years with epigastric burning, dyspepsia, regurgitation were included and with history of eradication therapy, antibiotic or NSAID use in the last 6 months or surgery of upper GI tract months were excluded. Type 2 diabetics were placed in one group and non-diabetic individuals in another. Both groups were compared for presence of H. pylori infection. Data was analysed using SPSS. Demographic variables included age, gender and status of H. pylori infection. Quantitative data was expressed as frequency and percentages. Chi-square test was applied to test for significance keeping p-value of <0.05 statistically significant.
Results: From 480 patients, 355 patients showed positive H. pylori, among them 282 were diabetic and 73 non-diabetic (p-value <0.001). Amongst the 355 diabetics, 55% were male Among 73 non-diabetics, 64% were male. All the patients in the study had dyspeptic symptoms and complained of dyspepsia, epigastric burning and regurgitation.
Conclusions: A substantial relationship between H. pylori infection among type 2 diabetes mellitus patients was observed compared to non-diabetics. As a result, diabetic patients having active dyspeptic symptoms should undergo further confirmatory tests for diagnosing H. pylori infection.
Metrics
References
Eusebi LH, Zagari RM, Bazzoli F. Epidemiology of Helicobacter pylori infection. Helicobacter. 2014;19:1-5.
Mishra S. Is Helicobacter pylori good or bad? European J Clin Microbiol Infect Dis. 2013;32(3):301-4.
Dorer MS, Cohen IE, Sessler TH, Fero J, Salama NR. Natural competence promotes Helicobacter pylori chronic infection. Infec Immunity. 2013;81(1):209-15.
Chen TP, Hung HF, Chen MK, Lai HH, Hsu WF, Huang KC, et al. Helicobacter pylori infection is positively associated with metabolic syndrome in Taiwanese adults: a cross‐sectional study. Helicobacter. 2015;20(3):184-91.
Lee YC, Chiang TH, Chou CK, Tu YK, Liao WC, Wu MS, et al. Association between Helicobacter pylori eradication and gastric cancer incidence: a systematic review and meta-analysis. Gastroenterol. 2016;150(5):1113-24.
He C, Yang Z, Lu NH. Helicobacter pylori infection and diabetes: is it a myth or fact? World J Gastroenterol. 2014;20(16):4607-10.
Bajaj S, Rekwal L, Misra SP, Misra V, Yadav RK, Srivastava A. Association of Helicobacter pylori infection with type 2 diabetes. Indian J Endocrin Metab. 2014;18(5):694-9.
Wang F, Meng W, Wang B, Qiao L. Helicobacter pylori-induced gastric inflammation and gastric cancer. Cancer Letters. 2014;345(2):196-202.
Vafaeimanesh J, Bagherzadeh M, Heidari A, Motii F, Parham M. Diabetic patients infected with Helicobacter pylori have a higher Insulin Resistance Degree. Caspian J Int Med. 2014;5(3):137-42.
Zhou X, Zhang C, Wu J, Zhang G. Association between Helicobacter pylori infection and diabetes mellitus: a meta-analysis of observational studies. Diab Res Clin Practice. 2013;99(2):200-8.
Hsieh MC, Wang SS, Hsieh YT, Kuo FC, Soon MS, Wu DC. Helicobacter pylori infection associated with high HbA1c and type 2 diabetes. European J Clinic Investigation. 2013;43(9):949-56.
Dai YN, Yu WL, Zhu HT, Ding JX, Yu CH, Li YM. Is Helicobacter pylori infection associated with glycemic control in diabetics? World J Gastroenterol. 2015;21(17):5407-16.
Han X, Li Y, Wang J, Liu B, Hu H, Li X, et al. Helicobacter pylori infection is associated with type 2 diabetes among a middle‐and old‐age Chinese population. Diab Metab Res Reviews. 2016;32(1):95-101.
Tamura T, Morita E, Kawai S, Sasakabe T, Sugimoto Y, Fukuda N, et al. No association between Helicobacter pylori infection and diabetes mellitus among a general Japanese population: a cross-sectional study. Springer Plus. 2015;4(1):602-9.
Cheng KP, Yang YJ, Hung HC, Lin CH, Wu CT, Hung MH, et al. Helicobacter pylori eradication improves glycemic control in type 2 diabetes patients with asymptomatic active Helicobacter pylori infection. J Diabetes Investigation. 2019;10(4):1092-101.
Devrajani BR, Shah SZ, Soomro AA, Devrajani T. Type 2 diabetes mellitus: A risk factor for Helicobacter pylori infection: A hospital based case-control study. Int J Diab. 2010;30(1):22-6.
Ebule IA, Djune FA, Njeambosay BA, Doh GN, Metaghue G. Association of Helicobacter pylori infection and diabetes mellitus type 2 subjects in yaounde cameroon using a panel of serum biomarkers (PGII, HPIGG): a case control study. J Clin Gastroenterol Treat. 2017;3:53-8.
Jeon CY, Haan MN, Cheng C, Clayton ER, Mayeda ER, Miller JW, et al. Helicobacter pylori infection is associated with an increased rate of diabetes. Diab Care. 2012;35(3):520-5.
Huang Y, Sun J, Wang X, Tao X, Wang H, Tan W. Helicobacter pylori infection decreases metformin tolerance in patients with type 2 diabetes mellitus. Diab Tech Therap. 2015;17(2):128-33.
Xia HH, Talley NJ, Kam EP, Young LJ, Hammer J, Horowitz M. Helicobacter pylori infection is not associated with diabetes mellitus, nor with upper gastrointestinal symptoms in diabetes mellitus. Am J Gastroenterol. 2001;96(4):1039-47.
Wali N, Waheed A, Aslam M. Association of Helicobacter pylori infection in patients suffering from type 2 diabetes mellitus. PJMHS. 2018;12(2):535-7.
Zafar KS, Ram V, Kumar M. A study of Helicobacter pylori infection in diabetes mellitus. Int J Res Med Sci. 2016;4(9):4166-71.
Downloads
Published
How to Cite
Issue
Section
